Rchr
J-GLOBAL ID：202001009981001730
Update date: Apr. 10, 2024
Doi Toshihiko
ドイ トシヒコ | Doi Toshihiko
Affiliation and department：
Job title：
先端医療科長
Research theme for competitive and other funds (4)：
- 2017 - 2022 Association of immune responses with racial differences of cancer development
- 2017 - 2022 New Classification of triple negative breast cancer (TNBC) based on immune status with clinical characteristic
- 2017 - 2018 Immunosuppressive mechanisms for anti-tumor immune responses depending on antigenicity
- 2015 - 2017 Identification of new molecule for regulatory T cells in an anti-tumor immunity
Papers (188)：
-
Toshihiko Doi, Shunji Takahashi, Daisuke Aoki, Kan Yonemori, Hiroki Hara, Kosei Hasegawa, Kazuhiro Takehara, Kenichi Harano, Mayu Yunokawa, Hiroyuki Nomura, et al. A first-in-human phase I study of TAS-117, an allosteric AKT inhibitor, in patients with advanced solid tumors. Cancer chemotherapy and pharmacology. 2024
-
Shigehiro Koganemaru, Hirobumi Fuchigami, Daiki Yamashita, Chihiro Morizono, Hironori Sunakawa, Akihito Kawazoe, Yoshiaki Nakamura, Yasutoshi Kuboki, Kohei Shitara, Tomonori Yano, et al. Quantitative analysis of the concentration of FTD in tumor hypoxic regions using a novel platform combining functional endoscopy and mass spectrometry. Clinical pharmacology and therapeutics. 2023
-
Shota Fukuoka, Yoshikatsu Koga, Mayumi Yamauchi, Shigehiro Koganemaru, Masahiro Yasunaga, Kohei Shitara, Toshihiko Doi, Takayuki Yoshino, Toshio Kuronita, Brian Elenbaas, et al. p70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab. Scientific reports. 2023. 13. 1. 16017-16017
-
Toshihiko Doi, Nobuaki Matsubara, Yoichi Naito, Yasutoshi Kuboki, Kenichi Harano, Makiko Ono, Tetsuya Urasaki, Akihiro Ohmoto, Tsubasa Kawanai, Takashi Hisai, et al. First-in-human study of E7130 (a tumor microenvironment-ameliorating microtubule inhibitor) in patients with advanced solid tumors: Primary results of the dose-escalation part. Cancer. 2023
-
Shigehiro Koganemaru, Takayuki Kawai, Hirobumi Fuchigami, Naoyuki Maeda, Kumiko Koyama, Yasutoshi Kuboki, Toru Mukohara, Toshihiko Doi, Masahiro Yasunaga. Quantitative analysis of drug distribution in heterogeneous tissues using dual-stacking capillary electrophoresis-mass spectrometry. British journal of pharmacology. 2022. 180. 6. 762-774
ｍore...
MISC (40)：
-
熊谷 尚悟, 小山 正平, 板橋 耕太, 冨樫 庸介, 吉田 達哉, 石井 源一郎, 河津 正人, 山崎 直也, 坪井 正博, 谷田部 恭, et al. 腫瘍微小環境における制御性T細胞に特徴的な代謝学的チェックポイントの同定(Identification of a distinctive metabolic checkpoint of regulatory T cells in the tumor microenvironment). 日本癌学会総会記事. 2022. 81回. CES1-3
-
Yoshitaka Honma, Yukinori Kurokawa, Akira Sawaki, Yoichi Naito, Shiro Iwagami, Hideo Baba, Yoshito Komatsu, Toshirou Nishida, Toshihiko Doi. Randomized, double-blind, placebo (PL)-controlled, phase III trial of pimitespib (TAS-116), an oral inhibitor of heat shock protein 90 (HSP90), in patients (pts) with advanced gastrointestinal stromal tumor (GIST) refractory to imatinib (IM), sunitinib (SU) and regorafenib (REG). JOURNAL OF CLINICAL ONCOLOGY. 2021. 39. 15
-
Shanu Modi, Haeseong Park, Rashmi K. Murthy, Hiroji Iwata, Kenji Tamura, Junji Tsurutani, Alvaro Moreno-Aspitia, Toshihiko Doi, Yasuaki Sagara, Charles Redfern, et al. HER2-Targeted Therapies in HER2-Low-Expressing Breast Cancer Reply. JOURNAL OF CLINICAL ONCOLOGY. 2020. 38. 28
-
Masataka Yagisawa, Kentaro Sawada, Yoshiaki Nakamura, Takahiro Ishii, Yohei Kubota, Hiromichi Nakajima, Tomoko Jogo, Akinori Sasaki, Saori Mishima, Daisuke Kotani, et al. Molecular landscape and prognostic value of HER2 low-expression on metastatic colorectal cancer. JOURNAL OF CLINICAL ONCOLOGY. 2020. 38. 4
-
平川環, 平川環, 川井隆之, 清水義宏, 設楽紘平, 小金丸茂博, 久保木恭利, 土井俊彦, 安永正浩. Discovery of new biomarkers against refractory cancer using in situ level mass spectrometry informatics. 日本癌学会学術総会抄録集(Web). 2020. 79th
ｍore...
Education (2)：
- 1989 - 1994 岡山大学大学院 医学研究科 第一内科
- - 1989 岡山大学 医学部
Professional career (1)：
Work history (2)：
- 2002/04 - 現在 国立研究開発法人 国立がん研究センター東病院
- 1994/04 - 2002/03 国立四国がんセンター 内科
Return to Previous Page
