Niitsu Ai

ニイツアイ | Niitsu Ai

Affiliation and department：
Job title： Team Leader/PRESTO Researcher

Research field (2)： Bioorganic chemistry , Biophysics

Research keywords (5)：膜タンパク質・ペプチド理論設計 , ペプチド化学 , 合成生物学 , 分子動力学 , 構造生物学

Research theme for competitive and other funds (6)：

2024 - 2026 無細胞分子システムで機能する膜貫通タンパク質モジュールの理論設計
2022 - 2025 自在配列膜貫通ペプチド精密設計法の開発と機能開拓
2022 - 2024 無細胞分子システムを支える汎用膜貫通ペプチドモジュールの理論設計
2021 - 2023 膜電位応答型de novo設計αヘリックスペプチドチャネルの創製と機能の解明
2017 - 2021 Folding-mechanism-based design of self-assembling channel peptides aided by molecular dynamics simulations

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Papers (13)：

Cheng Tan, Ai Niitsu, Yuji Sugita. Highly Charged Proteins and Their Repulsive Interactions Antagonize Biomolecular Condensation. JACS Au. 2023. 3. 3. 834-848
Ai Niitsu, Yuji Sugita. Towards de novo design of transmembrane α-helical assemblies using structural modelling and molecular dynamics simulation. Physical Chemistry Chemical Physics. 2023. 25. 5. 3595-3606
Alistair J. Scott, Ai Niitsu, Huong T. Kratochvil, Eric J. M. Lang, Jason T. Sengel, William M. Dawson, Kozhinjampara R. Mahendran, Marco Mravic, Andrew R. Thomson, R. Leo Brady, et al. Constructing ion channels from water-soluble α-helical barrels. Nature Chemistry. 2021. 13. 7. 643-650
Ai Niitsu, Suyong Re, Hiraku Oshima, Motoshi Kamiya, Yuji Sugita. De Novo Prediction of Binders and Nonbinders for T4 Lysozyme by gREST Simulations. Journal of chemical information and modeling. 2019. 59. 9. 3879-3888
Ai Niitsu, Ayako Egawa, Keisuke Ikeda, Kazuo Tachibana, Toshimichi Fujiwara. Veratridine binding to a transmembrane helix of sodium channel Nav1.4 determined by solid-state NMR. Bioorganic & medicinal chemistry. 2018. 26. 21. 5644-5653

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MISC (5)：

新津藍. De novo設計ナノポアの創製. 生物工学会誌. 2023. 101. 8
Cheng Tan, 新津藍, 依田隆夫, 杉田有治. 分子シミュレーションで理解する相分離のメカニズム. 実験医学別冊相分離解析プロトコール(羊土社). 2022
Free-energy Calculation of Protein-Ligand Binding Using Molecular Dynamics Simulation Software "GENESIS". 2021. 40. 1. 22-28
NIITSU Ai. Designing Novel Peptide Pores from a Barrel-Shaped Protein Scaffold. Seibutsu Butsuri. 2018. 58. 4. 211-213
Ai Niitsu. Characterization of protein/peptide pores in a planar lipid bilayer by single channel current recording. PSSJ Archives. 2017. 10. e086

Lectures and oral presentations (11)：

動的膜ペプチド会合体のデザインに向けて
(第24回日本蛋白質科学会年会 2024)
Membrane peptide assemblies towards dynamic, designed proteins
(The 3rd International Symposium on Biofunctional Chemistry 2024)
膜ペプチド理論設計による生体分子材料の開発とその動的機能・構造
(第104回日本化学会春季年会 2024)
Designed peptide channels and pores: structural stability and dynamics
(IPR-iCeMS joint seminar “Biological Chemistry on Membranes 2023)
人工設計ペプチドイオンチャネルの構造ダイナミクス
(第23回日本蛋白質科学会年会 2023)

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Education (3)：

- 2012 The University of Tokyo Graduate School of Science Department of Chemistry
- 2009 The University of Tokyo Graduate School of Science Department of Chemistry
- 2007 The University of Tokyo Faculty of Science Department of Chemistry

Work history (8)：

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Awards (4)：

2024/03 - 日本化学会女性化学者奨励賞
2017 - 日本生物物理学会若手奨励賞
2017 - 日本蛋白質科学会若手奨励賞優秀賞
2015 - Gordon Research Conference (membrane protein folding, MA, USA) Outstanding poster award

Association Membership(s) (3)：

日本蛋白質科学会 , 日本生物物理学会 , 日本化学会

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