Rchr
J-GLOBAL ID：202001010694601083   Update date: Jul. 17, 2024

Ito Yukako

イトウ ユカコ | Ito Yukako
Affiliation and department：
京都薬科大学 薬物動態学分野

About 京都薬科大学 薬物動態学分野


Job title： 講師
Research field  (2)： Tumor diagnostics and therapeutics ,  Clinical pharmacy
Research keywords  (1)： pharmacokinetics, PK/PD, cancer chemotherapy, circulating tumor cell, liquid biopsy, biomarker, coiorectal cancer, pancreatic cancer
Research theme for competitive and other funds  (7)：
  • 2021 - 2024 Practical utility of liquid biopsy for management of pancreatic cancer chemotherapy
  • 2018 - 2021 Liquid biopsy for management of pancreatic cancer chemotherapy
  • 2015 - 2018 Novel systmen for predicting adverse effect of neuropathy in oxaliplatin based chemotherapy
  • 2012 - 2015 Novel monitoring system of fluoropyrimidines for personalized therapy based on PK/PD modeling using dihydropyrimidine dehydrogenase activity as a biomarker of predicting efficacy and side-effects.
  • 2010 - 2012 Microneedle skin vaccine
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Papers (51)：
  • Shinji Kobuchi, Mayuka Arimoto, Yukako Ito. Translational pharmacokinetic-toxicodynamic model of myelosuppression for dose optimization in combination chemotherapy of capecitabine and oxaliplatin from rats to humans. The Journal of pharmacology and experimental therapeutics. 2024
  • Yasuhito Tsukushi, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda. Pharmacokinetic-toxicodynamic Modeling to Elucidate the Involvement of Dorsal Root Ganglion Neuron in Oxaliplatin-induced Peripheral Neuropathy. Anticancer research. 2024. 44. 2. 575-584
  • Shinji Kobuchi, Atsuko Morita, Shizuka Jonan, Kikuko Amagase, Yukako Ito. Translational PK-PD/TD modeling of antitumor effects and peripheral neuropathy in gemcitabine and nab-paclitaxel chemotherapy from xenograft mice to patients for optimal dose and schedule. Cancer chemotherapy and pharmacology. 2023
  • Yukako Ito, Shinji Kobuchi, Amiri Kawakita, Kazuki Tosaka, Yume Matsunaga, Shoma Yoshioka, Shizuka Jonan, Kikuko Amagase, Katsunori Hashimoto, Mitsuro Kanda, et al. Mobilization of Circulating Tumor Cells after Short- and Long-Term FOLFIRINOX and GEM/nab-PTX Chemotherapy in Xenograft Mouse Models of Human Pancreatic Cancer. Cancers. 2023
  • Takumi Tanaka, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda. Pharmacokinetic evaluation of oxaliplatin combined with S-1 (SOX) chemotherapy in a rat model of colorectal cancer with acute kidney injury: predictive renal biomarkers for dose optimisation. Xenobiotica; the fate of foreign compounds in biological systems. 2023. 1-8
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MISC (58)：
  • 神田 直哉, 奥見 泰地, 可野 裕万, 舘 向日葵, 河渕 真治, 伊藤 由佳子, 栄田 敏之. 敗血症モデルラットにおける抗MRSA薬の腎臓移行性. 日本薬学会年会要旨集. 2020. 140年会. 28J-am01S
  • 片岡 楓, 松尾 直弥, 河渕 真治, 伊藤 由佳子, 加藤 健一郎, 早川 哲雄, 栄田 敏之. ナトリウム・グルコース共輸送体2(SGLT2)阻害剤dapagliflozinの血漿中濃度と有効性との関係. 日本薬学会年会要旨集. 2020. 140年会. 28J-am03S
  • 中村 謙吾, 藤井 優佳, 河渕 真治, 伊藤 由佳子, 栄田 敏之. 膵がんモデルラットに対するゲムシタビン・ナブパクリタキセル療法時のモデリング&シミュレーションの有用性. 日本薬学会年会要旨集. 2020. 140年会. 28J-am04S
  • 三木 優花, 真鍋 諒子, 河渕 真治, 倉田 裕美, 伊藤 由佳子, 三浦 誠, 栄田 敏之. β-ラクタマーゼ阻害剤配合抗菌薬の治療規定因子に関する臨床的・基礎的検討. 日本薬学会年会要旨集. 2020. 140年会. 28J-am06S
  • 疇地 優香, 河渕 真治, 伊藤 由佳子, 栄田 敏之. オキサリプラチンベース化学療法時の腎障害マネジメントのための母集団薬物動態速度論的解析の利用. 臨床薬理. 2019. 50. Suppl. S242-S242
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Awards (3)：
  • 2017/09 - 日本TDM会 2017年度 海老原賞 「IATDMCT学術大会」派遣賞
  • 2014/06 - Journal of Drug Delivery Science and Technology Journal of Drug Delivery Science and Technology Best Paper Award 2014 Prolonged hypoglycemic effects obtained by two-layered dissolving microneedles containing insulin glargine
  • 2004/01 - 日本薬学会 2004年度 近畿支部奨励賞受賞
Association Membership(s) (7)：
Japanese Cancer Association ,  Japan Society of Clinical Oncology ,  Japanese Society of Pharmaceutical Health Care and Sciences ,  Japanese Society of Therapeutic Drug Monitoring ,  The Japanese Society for the Study of Xenobiotics ,  the Japanese Society of Clinical Pharmacology and Therapeutics ,  The pharmaceutical society of Japan
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