Ito Yukako

イトウユカコ | Ito Yukako

Affiliation and department：
Job title：講師

Research field (2)： Tumor diagnostics and therapeutics , Clinical pharmacy

Research keywords (1)： pharmacokinetics, PK/PD, cancer chemotherapy, circulating tumor cell, liquid biopsy, biomarker, coiorectal cancer, pancreatic cancer

Research theme for competitive and other funds (7)：

2021 - 2024 Practical utility of liquid biopsy for management of pancreatic cancer chemotherapy
2018 - 2021 Liquid biopsy for management of pancreatic cancer chemotherapy
2015 - 2018 Novel systmen for predicting adverse effect of neuropathy in oxaliplatin based chemotherapy
2012 - 2015 Novel monitoring system of fluoropyrimidines for personalized therapy based on PK/PD modeling using dihydropyrimidine dehydrogenase activity as a biomarker of predicting efficacy and side-effects.
2010 - 2012 Microneedle skin vaccine

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Papers (48)：

Yasuhito Tsukushi, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda. Pharmacokinetic-toxicodynamic Modeling to Elucidate the Involvement of Dorsal Root Ganglion Neuron in Oxaliplatin-induced Peripheral Neuropathy. Anticancer research. 2024. 44. 2. 575-584
Shinji Kobuchi, Atsuko Morita, Shizuka Jonan, Kikuko Amagase, Yukako Ito. Translational PK-PD/TD modeling of antitumor effects and peripheral neuropathy in gemcitabine and nab-paclitaxel chemotherapy from xenograft mice to patients for optimal dose and schedule. Cancer chemotherapy and pharmacology. 2023
Yukako Ito, Shinji Kobuchi, Amiri Kawakita, Kazuki Tosaka, Yume Matsunaga, Shoma Yoshioka, Shizuka Jonan, Kikuko Amagase, Katsunori Hashimoto, Mitsuro Kanda, et al. Mobilization of Circulating Tumor Cells after Short- and Long-Term FOLFIRINOX and GEM/nab-PTX Chemotherapy in Xenograft Mouse Models of Human Pancreatic Cancer. Cancers. 2023
Takumi Tanaka, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda. Pharmacokinetic evaluation of oxaliplatin combined with S-1 (SOX) chemotherapy in a rat model of colorectal cancer with acute kidney injury: predictive renal biomarkers for dose optimisation. Xenobiotica; the fate of foreign compounds in biological systems. 2023. 1-8
栄井修平, 河渕真治, 伊藤由佳子, 藤野秀樹, 加藤健一郎, 早川哲雄, 栄田敏之. 2型糖尿病患者におけるナトリウム・グルコース共輸送体2阻害剤dapagliflozin投与後のHbA1c推移の変動要因の解明. TDM研究. 2023. 40. 2. 180-180

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MISC (58)：

神田直哉, 奥見泰地, 可野裕万, 舘向日葵, 河渕真治, 伊藤由佳子, 栄田敏之. 敗血症モデルラットにおける抗MRSA薬の腎臓移行性. 日本薬学会年会要旨集. 2020. 140年会. 28J-am01S
片岡楓, 松尾直弥, 河渕真治, 伊藤由佳子, 加藤健一郎, 早川哲雄, 栄田敏之. ナトリウム・グルコース共輸送体2(SGLT2)阻害剤dapagliflozinの血漿中濃度と有効性との関係. 日本薬学会年会要旨集. 2020. 140年会. 28J-am03S
中村謙吾, 藤井優佳, 河渕真治, 伊藤由佳子, 栄田敏之. 膵がんモデルラットに対するゲムシタビン・ナブパクリタキセル療法時のモデリング&シミュレーションの有用性. 日本薬学会年会要旨集. 2020. 140年会. 28J-am04S
三木優花, 真鍋諒子, 河渕真治, 倉田裕美, 伊藤由佳子, 三浦誠, 栄田敏之. β-ラクタマーゼ阻害剤配合抗菌薬の治療規定因子に関する臨床的・基礎的検討. 日本薬学会年会要旨集. 2020. 140年会. 28J-am06S
疇地優香, 河渕真治, 伊藤由佳子, 栄田敏之. オキサリプラチンベース化学療法時の腎障害マネジメントのための母集団薬物動態速度論的解析の利用. 臨床薬理. 2019. 50. Suppl. S242-S242

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Awards (3)：

2017/09 - 日本TDM会 2017年度海老原賞「IATDMCT学術大会」派遣賞
2014/06 - Journal of Drug Delivery Science and Technology Journal of Drug Delivery Science and Technology Best Paper Award 2014 Prolonged hypoglycemic effects obtained by two-layered dissolving microneedles containing insulin glargine
2004/01 - 日本薬学会 2004年度近畿支部奨励賞受賞

Association Membership(s) (7)：

Japanese Cancer Association , Japan Society of Clinical Oncology , Japanese Society of Pharmaceutical Health Care and Sciences , Japanese Society of Therapeutic Drug Monitoring , The Japanese Society for the Study of Xenobiotics , the Japanese Society of Clinical Pharmacology and Therapeutics , The pharmaceutical society of Japan

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