Rchr
J-GLOBAL ID：202001010810004870
Update date: Jun. 01, 2024
Lee Yongchan
リ ヨンチャン | Lee Yongchan
Affiliation and department：
Research field (1)：
Structural biochemistry
Research keywords (5)：
構造生物学
, タンパク質
, 膜輸送体
, クライオ電子顕微鏡
, X線結晶構造解析
Research theme for competitive and other funds (4)：
- 2022 - 2025 Molecular mechanism of amino acid harmonization: a paradigm of heterodimeric amino acid transporters
- 2021 - 2025 Elucidating higher-order dynamics and disruption mechanism of the brush border membrane involved in nutrient absorption
- 2021 - 2024 Structural and functional elucidation of L-type amino acid transporter under lipid environment
- 2016 - 2018 植物の栄養分配に関わる膜輸送体タンパク質の構造機能解析
Papers (12)：
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Sawako Goto, Akihisa Tsutsumi, Yongchan Lee, Michihiro Hosojima, Hideyuki Kabasawa, Koichi Komochi, Satoru Nagatoishi, Kazuya Takemoto, Kouhei Tsumoto, Tomohiro Nishizawa, et al. Cryo-EM structures elucidate the multiligand receptor nature of megalin. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 22. e2318859121
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Yongchan Lee, Chunhuan Jin, Ryuichi Ohgaki, Minhui Xu, Satoshi Ogasawara, Rangana Warshamanage, Keitaro Yamashita, Garib Murshudov, Osamu Nureki, Takeshi Murata, et al. Structural basis of anticancer drug recognition and amino acid transport by LAT1. 2023
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Yongchan Lee, Outi Haapanen, Anton Altmeyer, Werner Kühlbrandt, Vivek Sharma, Volker Zickermann. Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations. Nature Communications. 2022. 13. 1
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Yongchan Lee, Pattama Wiriyasermkul, Pornparn Kongpracha, Satomi Moriyama, Deryck J Mills, Werner Kühlbrandt, Shushi Nagamori. Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria. Nature Communications. 2022. 13. 1. 2708-2708
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Yongchan Lee, Pattama Wiriyasermkul, Satomi Moriyama, Deryck J. Mills, Werner Kühlbr, t, Shushi Nagamori. Ca2+-mediated higher-order assembly of b0,+AT-rBAT is a key step for system b0,+ biogenesis and cystinuria. 2021
ｍore...
Professional career (1)：
- Ph.D. (The University of Tokyo)
Awards (5)：
- 2021/04 - KAZATO Research Foundation Kazato Research Encouragement Prize
- 2019/01 - Human Frontier Science Program Long-Term Fellowship Resolving the structures and mechanisms of heteromeric amino acid transporter by phase-plate cryo-EM
- 2018/06 - 東洋紡バイオテクノロジー財団 長期研究助成【二年助成】 クライオ電子顕微鏡を用いたアミノ酸輸送体の構造研究
- 2017/06 - The Protein Science Society of Japan Young Scientist Excellence Award Crystallographic analysis of the triose-phosphate/phosphate translocator in complex with two counter-substrates
- 2015/03 - 東京大学 研究奨励賞(修士)
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