TAKAGURI AKIRA

タカグリアキラ | TAKAGURI AKIRA

Affiliation and department：
Job title：准教授

Research field (1)： Pharmacology

Research keywords (1)：動脈硬化時計遺伝子薬理学

Research theme for competitive and other funds (11)：

2021 - 2024 腹部大動脈瘤の形成・破裂におけるHippo経路関連分子YAP1の生理的役割の解明
2021 - 2022 Hippo 経路関連分子 YAP1 を標的とした腹部大動脈瘤の新たな治療薬の創出
2018 - 2021 The role of Hippo pathway transcriptional co-activator, YAP1 in the pathogenesis of Atherosclerosis
2020 - 2021 向知性の活性増強を指向した新たなベンゾチアジアジン誘導体の創製と活性評価
2019 - 2020 末梢時計遺伝子群を基盤とした新たな動脈硬化治療戦略の確立

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Papers (39)：

Akira Takaguri, Rena Ishizaka, Shota Maki, Kumi Satoh. The role of tribbles homolog 2 in vascular smooth muscle cell proliferation. Cell Biology International. 2023. 47. 4. 787-795
Keisuke Sato, Shoya Endo, Natsuki Ota, Akira Takaguri, Kumi Satoh, Ryosuke Tatsunami. Epalrestat Enhances MTS Reduction Activity Independent of Cell Numbers in Bovine Aortic Endothelial Cells. Pharmacology & Pharmacy. 2023. 14. 03. 59-71
Koji Wada, Akira Takaguri, Kyosuke Kaneda, Megumi Mizukami, Yuji Suzuki, Hiroshi Yamashita. Rational design and structure-activity relationship studies reveal new esterified C20-diterpenoid alkaloid analogues active against MCF-7 human breast cancer cells. Journal of Natural Medicines. 2022. 77. 2. 276-283
Chiba T, Takaguri A, Kooka A, Kowatari K, Yoshizawa M, Fukushi Y, Fuminori H, Hideki S, Fujisawa M, Wada S, et al. Suppression of milk-derived miR-148a caused by stress plays a role in the decrease in intestinal ZO-1 expression in infants. Clinical Nutrition. 2022. 41. 12. 2691-2698
Tetsuji Miura, Tatsuya Sato, Toshiyuki Yano, Akira Takaguri, Takayuki Miki, Noritsugu Tohse, Keitaro Nishizawa. Role of Erythropoiesis-Stimulating Agents in Cardiovascular Protection in CKD Patients: Reappraisal of Their Impact and Mechanisms. Cardiovascular Drugs and Therapy. 2022

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MISC (3)：

Kumi Satoh, Tomohito Shibata, Akira Takaguri, Seiichiro Kano, Kazuo Ichihara. Inhibitory Mechanism of TNF-alpha-Induced Serine Phosphorylation of IRS-1 Mediated by AMP-Activated Protein Kinase in 3T3-L1 Adipocytes. DIABETES. 2010. 59. A381-A381
Akira Takaguri, Hirotoshi Utsnomiya, Ryohei Kono, Shin-ichi Akazawa, Satoru Eguchi. An ethyl acetate extract from a subaleurone layer of Japanese rice inhibits angiotensin II-induced signal transduction and hypertrophy in vascular smooth muscle cells. FASEB JOURNAL. 2010. 24
Kumi Satoh, Akira Takaguri, Seiichiro Kano, Kazuo Ichihara. Atorvastatin Affects Insulin Signal Transduction by Inhibiting Rho GTPase in 3T3L1 Adipocytes. DIABETES. 2009. 58. A344-A344

Books (2)：

Lectures and oral presentations (67)：

腎線維化における時計遺伝子BMAL1の役割
(日本薬学会北海道支部第150回例会 2023)
ドキソルビシンの心毒性におけるTRIB2の役割解明
(日本薬学会北海道支部第150回例会 2023)
血管平滑筋細胞の増殖・遊走におけるTRIB2の機能的役割
(第72回日本薬理学会北部会 2022)
時計遺伝子BMAL1は血管平滑筋細胞における炎症を制御する
(第34回北海道薬物作用談話会 2021)
血管平滑筋細胞の炎症に対する時計遺伝子BMAL1の関与
(第71回日本薬理学会北部会 2021)

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Education (4)：

Professional career (1)：

Work history (5)：

Committee career (4)：

Awards (1)：

Association Membership(s) (4)：

日本心脈管作動物質学会 , American Heart Association , 日本薬学会 , 日本薬理学会

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