KAWAI TOMOKO

カワイトモコ | KAWAI TOMOKO

Affiliation and department：
Job title： assistant professor

Research keywords (7)： physiology , reproductive system , nerves , mechanobiology , Medical and Biological Engineering , endocrinology , internal environment factors

Research theme for competitive and other funds (12)：

2024 - 2027 Elucidation of the regulatory mechanism of sperm motility and fertility by the parasympathetic nervous and the demonstration using a sperm culture system
2023 - 2025 Elucidation of the mechanism that regulate the sperm function by autonomic nerves and the development of the system to improve the sperm quality
2024 - 2025 Elucidation of the mechanism of reproductive diseases caused by environment focusing on the novel oocyte-secreted factor.
2023 - 2025 Elucidation of the mechanism that regulate the sperm motility by parasympathetic nerves and the development of the system to improve the sperm motility
2023 - 2024 Creation of the fundamental technology for producing the high-quality of fertilized oocytes in mammals

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Papers (22)：

Elesh IF, Marey MA, Zinnah MA, Akhtar I, Kawai T, Naim F, Goda W, Rawash ARA, Sasaki M, Shimada M, Miyamoto A. Peptidoglycan switches off the TLR2-mediated sperm recognition and triggers sperm localization in the bovine endometrium. Frontiers in Immunology. 2021
Nakanishi T, Tanaka R, Tonai S, Lee JY, Yamaoka M, Kawai T, Okamoto A, Shimada M, Yamashita Y. LH induces de novo cholesterol biosynthesis via SREBP activation in granulosa cells during ovulation in female mice. Endocrinology. 2021. 162. 11
Kawai T, Richards JS, Shimada M. Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development. Communications Biology. 2021
Kawai T, Shimada M. Pretreatment of ovaries with collagenase before vitrification keeps the ovarian reserve by maintaining cell-cell adhesion integrity in ovarian follicles. Scientific reports. 2020. 10. 6841
Kawai T, Shimada M. The proliferation of granulosa cells during ovarian follicular development ~the regulatory mechanisms and the physiological roles to acquire the responsible ability to ovulation stimuli~. Journal of Mammalian Ova Research. 2020. 37. 1

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MISC (2)：

川合智子, Hoque SAM, JoAnne, S. Richards, 島田昌之. 卵胞直径の拡大で可能となる顆粒膜細胞のレチノイン酸合成がLH受容体発現を誘導. 日本生殖内分泌学会雑誌. 2020. 25. 21-23
島田昌之, 川合智子, 星野由美. 卵胞発育の生理: 卵胞発育と卵成熟. 臨床婦人科産科. 2016. 70. 12. 1110-1116

Books (2)：

SDGsに向けた生物生産学入門
共立出版 2021
妊孕性温存のすべて
中外医学社 2021

Lectures and oral presentations (46)：

Changes of ovarian hardness and elasticity affect the development and function of secondary follicles
(68th Annual Meeting of Biophysical Society 2024)
生殖システムを司る新たな主要メカニズムの解明と生殖医療への展開
(岡山大学みなす講演会 2023)
コラーゲンが豊富な卵胞周囲の硬さ環境が卵胞の発育と機能に果たす役割
(神戸大学バイオシグナル総合研究センター大学院セミナー 2022)
円形精子細胞の体外培養条件の検討
(第78回九州・沖縄生殖医学会 2022)
円形精子細胞の体外培養条件の検討
(第66回日本生殖医学会 2021)

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Education (3)：

2011 - 2015 Hiroshima University Graduate School of Biosphere Science
2009 - 2011 Hiroshima University Graduate School of Biosphere Science
2005 - 2009 Kindai University Faculty of Biology-oriented science and technology

Professional career (1)：

Ph.D. (Agriculture) (Hiroshima University)

Work history (5)：

2023/05 - 現在 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences Assistant Professor
2019/04 - 2022/04 Hiroshima University Graduate School of Integrated Sciences for Life Assistant Professor
2015/04 - 2019/03 Hiroshima University Graduate School of Biosphere Science postdoctoral researcher
2013/04 - 2015/03 Japan Society for the Promotion of Science Research Fellowship for Young Scientists DC2
2011/10 - 2012/09 Innovation Training Program for Young Technical Experts Working Researcher

Committee career (2)：

Okayama University Department of Animal Resources Usage Consultation Committee
Okayama University Education Program Committee in Basic or Social Medical field

Awards (8)：

2020 - 第24回日本生殖内分泌学会学術奨励賞
2020 - 広島大学大学院統合生命科学研究科奨励賞
2019 - 第37回日本受精着床学会世界体外受精会議記念賞
2018 - 第59回日本卵子学会学術奨励賞
2018 - 51st Society for the Study of Reproduction Annual Meeting Best international abstract award

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Association Membership(s) (11)：

Society for the Study of Reproduction , Biophysical Society , The American Society for Cell Biology , American Society for Reproductive Medicine , Japanese Society for Medical and Biological Engineering , The Physiological Society of Japan , Journal of Mammalian Ova Research , The Society for reproduction and development , Japan Society of Fertilization and Implantation , Japan society for reproductive medicine , Japan Society of Reproductive Endocrinology

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