Nagashima Hiroaki

ナガシマヒロアキ | Nagashima Hiroaki

Affiliation and department：
Job title：助教

Research field (2)： Tumor biology , Neurosurgery

Research keywords (2)： Metabolism , Brain tumor

Research theme for competitive and other funds (2)：

2022 - 2025 Development of new treatments for medulloblastoma targeting macrophage
2021 - 2025 Targeting PARG in malignant glioma therapy

Papers (70)：

篠山隆司, 田中一寛, 長嶋宏明, 藤田祐一, 岩橋洋文, 小松正人, 児玉良典, 伊藤智雄, 廣瀬隆則. 脳腫瘍診断におけるliquid biopsyの可能性グリオーマおよび中枢神経悪性リンパ腫患者の髄液中炎症性マーカーと予後. Brain Tumor Pathology. 2023. 40. Suppl. 068-068
Fumiyuki Yamasaki, Hirotaka Fudaba, Kenichiro Asano, Takashi Sasayama, Manabu Natsumeda, Taichi Shimabukuro, Kotaro Taguchi, Shinichiro Koizumi, Noriyuki Nakayama, Kentaro Fujii, et al. Multidrug chemotherapy, whole-brain radiation and cytarabine therapy for primary central nervous system lymphoma in elderly patients with dose modification based on geriatric assessment: study protocol for a phase II, multicentre, non-randomised study. BMJ open. 2023. 13. 4. e071350
Hirofumi Iwahashi, Hiroaki Nagashima, Kazuhiro Tanaka, Takiko Uno, Mitsuru Hashiguchi, Masahiro Maeyama, Yuichiro Somiya, Masato Komatsu, Takanori Hirose, Tomoo Itoh, et al. 2-Hydroxyglutarate magnetic resonance spectroscopy in adult brainstem glioma. Journal of neurosurgery. 2023. 1-8
Tomohiro Ishikawa, Yasuka Ogura, Kazuhiro Tanaka, Hiroaki Nagashima, Takashi Sasayama, Mitsuharu Endo, Yasuhiro Minami. Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell-like property of glioblastoma cells. Cancer Science. 2022. 114. 2. 561-573
石川智弘, 遠藤光晴, 田中一寛, 長嶋宏明, 篠山隆司, 南康博. グリオブラストーマ細胞におけるRor1の発現制御とRor1による幹細胞性維持機構の解析(Molecular mechanism regulating expression of Ror1 in GSCs and the role of Ror1 in maintaining their stemness). 日本癌学会総会記事. 2022. 81回. P-2118

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MISC (37)：

上月惇, 十河正弥, 岡山公宣, 千原典夫, 上田健博, 関口兼司, 藤本陽介, 長嶋宏明, 篠山隆司, 松本理器. 円蓋部に限局するくも膜下出血で発症した脳静脈血栓症の3症例. 日本内科学会雑誌. 2022. 111
Hiroaki Nagashima, Kazuhiro Tanaka, Yuichi Fujita, Mitsuru Hashiguchi, Mashahiro Maeyama, Yuichiro Somiya, Takanori Hirose, Tomoo Itoh, Takashi Sasayama. 2-HYDROXYGLUTARATE MAGNETIC RESONANCE SPECTROSCOPY IN ADULT BRAINSTEM GLIOMA PATIENTS. NEURO-ONCOLOGY. 2021. 23. 131-131
Kazuhiro Tanaka, Hiroaki Nagashima, Yuichi Fujita, Mitsuru Hashiguchi, Takashi Sasayama. GLIOMA CELLS REPROGRAM SERINE-DEPENDENT ONE-CARBON METABOLISM TO SURVIVE GLUTAMINE STARVATION. NEURO-ONCOLOGY. 2021. 23. 202-202
長嶋宏明, 田中一寛, 橋口充, 藤田祐一, 前山昌博, 曽宮雄一郎, 廣瀬隆則, 伊藤智雄. 脳腫瘍遺伝子異常の画像診断 MR Spectroscopyを用いた2HG測定による成人脳幹グリオーマの遺伝子診断. Brain Tumor Pathology. 2021. 38. Suppl. 060-060
篠山隆司, 田中一寛, 金原史朗, 小松正人, 児玉良典, 山本暢之, 長嶋宏明, 南博信, 廣瀬隆則, 伊藤智雄. 癌ゲノム医療神戸大学医学部附属病院におけるがんゲノム医療の現状と課題. Brain Tumor Pathology. 2021. 38. Suppl. 067-067

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Books (2)：

小児脳神経外科学第2版
金芳堂 2015
最新ガイドライン準拠小児科診断、治療指針
中山書店 2012

Lectures and oral presentations (17)：

Predictors of sensitivity to combined temozolomide and PARP inhibitor in glioma
(24th Society of Neuro-oncology annual meeting 2019)
Poly(ADP-ribose) glycohydrolase inhibition sequesters NAD+ to potentiate the metabolic lethality of alkylating chemotherapy in IDH mutant tumor cells
(32nd EORTC-NCI-AACR Symposium 2020)
Magnetic resonance spectroscopy of glutamate and 2-hydroxyglutarate in patients with the IDH1 mutant glioma: A prospective validation study
(2018)
術前MR SpectroscopyによるグリオーマIDH1遺伝子変異予測の検討
(第47回日本神経放射線学会 2018)
脳幹グリオーマに対するMR Spectroscopyを用いたIDH遺伝子変異診断の有用性
(第35回日本脳腫瘍学会 2017)

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Work history (12)：

2021/01 - 現在神戸大学医学部医学研究科脳神経外科助教
2020/09 - 2020/12 神戸大学医学部医学研究科脳神経外科医員
2018/04 - 2020/08 Massachusetts General Hospital Neurosurgery Postdoctoral Fellow
2017/04 - 2018/03 兵庫県立加古川医療センター脳神経外科
2016/09 - 2017/03 神戸赤十字病院脳神経外科

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Awards (3)：

2021/09 - The 21st Annual Meeting of the Japan Society of Molecular Neurosurgery award Poly(ADP-ribose) glycohydrolase inhibition sequesters NAD+ to potentiate the metabolic lethality of alkylating chemotherapy in IDH mutant tumor cells
2020/11 - Poly(ADP-ribose) glycohydrolase inhibition sequesters NAD+ to potentiate the metabolic lethality of alkylating chemotherapy in IDH mutant tumor cells
2017/09 - Japan Neurosurgical Society Investigator Award Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma

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