YOSHIDA MICHIHARU

ヨシダミチハル | YOSHIDA MICHIHARU

Affiliation and department：
Other affiliations (1)：

Nagasaki University

Research field (1)： Tumor diagnostics and therapeutics

Research keywords (6)： malignant brain tumor , 5-aminolevulinic acid , sonodynamic therapy , drug-delivery system , blood-brain barrier , focused ultrasound

Research theme for competitive and other funds (5)：

2023 - 2026 悪性神経膠腫に対するsiRNAを使用した核酸医薬導入への挑戦
2023 - 2026 Development of a non-invasive delivery method for mRNA drugs for malignant brain tumors
2023 - 2025 悪性神経膠腫に対する薬剤封入リポソームの送達治療と脳内薬物動態の三次元解析
2021 - 2023 The establishment of drug-delivery system and the 3D-microimaging of intra-cerebral pharmacokinetics in malignant glioma
2020 - 2023 リピッドバブルとMRIガイド経頭蓋超音波による血液脳関門開口と脳内薬物送達

Papers (14)：

Soshi Gotan, Susumu Yamaguchi, Michiharu Yoshida, Mitsuto Iwanaga, Tsuyoshi Izumo, Takayuki Matsuo. Characteristics of a Pure Acute Subdural Hematoma Caused by Intracranial Aneurysm Rupture: A Case Report and Review of Literature. Cureus. 2024. 16. 8. e66575
Naoya Kato, Narumi Moriya, Makoto Matsumoto, Ayaka Matsuo, Michiharu Yoshida, Takeshi Hiu, Takayuki Matsuo, Yuuki Takashima, Mariko Kamiya, Hidefumi Mukai, et al. Synthesis of a novel adapter lipid using Fc-region mediated antibody modification for post-insert preparation of transferrin receptor targeted messenger RNA-loaded lipid nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics. 2024. 114468-114468
Michiharu Yoshida, Susumu Yamaguchi, Keisuke Iwasaki, Mitsuto Iwanaga. 5-aminolevulinic acid-guided endoscopic biopsy with violet light-emitting diode flashlight in malignant glioma: Technical note. Surgical neurology international. 2023. 14. 397-397
Michiharu Yoshida, Takeharu Kato, Takeshi Hiu, Yoshitaka Imaizumi, Simpei Morimoto, Daisuke Niino, Susumu Yamaguchi, Shiro Baba, Kenta Ujifuku, Koichi Yoshida, et al. Treatment of new-onset primary central nervous system lymphoma in elderly patients using RMPV chemotherapy: a single-institution experience. International journal of hematology. 2023
Susumu Yamaguchi, Michiharu Yoshida, Nobutaka Horie, Katsuya Satoh, Yuutaka Fukuda, Shunsuke Ishizaka, Koki Ogawa, Yoichi Morofuji, Takeshi Hiu, Tsuyoshi Izumo, et al. Stem Cell Therapy for Acute/Subacute Ischemic Stroke with a Focus on Intraarterial Stem Cell Transplantation: From Basic Research to Clinical Trials. Bioengineering. 2022. 10. 1. 33-33

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MISC (48)：

中村光流, 日宇健, 加藤丈晴, 吉田道春, 白濱麻衣, 後藤純寛, 松尾彩香, 馬場史郎, 氏福健太, 諸藤陽一, et al. 中枢神経原発悪性リンパ腫診断におけるフローサイトメトリーの果たす役割. 日本脳神経CI学会総会プログラム・抄録集. 2024. 47th
中村光流, 日宇健, 吉田道春, 馬場史郎, 氏福健太, 諸藤陽一, 吉田光一, 出雲剛, 松尾孝之. 80歳以上の高齢膠芽腫患者における治療成績の検討. 脳循環代謝. 2023. 35. 1. 85-85
松本眞, 松尾彩香, 森谷成美, 吉田道春, 日宇健, 神谷万里子, 松尾孝之, 川上茂. 新規Fc領域結合ペプチド修飾脂質を用いる脳腫瘍を標的とした抗体修飾脂質ナノ粒子の開発. 脳循環代謝. 2023. 35. 1. 115-115
神谷万里子, 日宇健, 大野海晴, 松尾彩香, 松本眞, 吉田道春, 松尾孝之, 川上茂. ペプチド脂質修飾mRNA封入脂質ナノ粒子の腫瘍内投与における発現特性の評価. 脳循環代謝. 2023. 35. 1. 116-116
吉田道春, 山口将, 林之茂, 上之郷眞木雄, 内田大貴, 定方英作, 原口渉, 小野智憲, 岩永充人, 案田岳夫. 地方市中病院のグリオーマ治療における脳腫瘍外科医の意義を考察してみた. 日本脳腫瘍の外科学会プログラム・抄録集. 2023. 28th

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Lectures and oral presentations (12)：

Brain drug delivery of mRNA encapsulated LNPs using focused ultrasound and microbubbles
(The 39th Annual Meeting of the Japan Society for Neuro-Oncology 2021)
Outcome and problem of R-MPV-A therapy for primary central nervous system lymphoma in the elderly
(2021)
A case report of ruptured anterior cerebral artery aneurysm with pituitary apoplexy
(STROKE 2021 2021)
Long-term experience of R-MPV-A therapy for primary central nervous system lymphoma
(The 79th Annual Meeting of the Japan Neurosurgical Society 2020)
A case report of ruptured anterior cerebral artery aneurysm with pituitary adenoma
(2020)

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Education (2)：

2014 - 2018 Hokkaido University Graduate School of Medicine
2003 - 2009 Tottori University Faculty of Medicine School of Medicine

Professional career (1)：

北海道大学大学院医学研究科脳神経外科学専攻博士課程 (北海道大学大学院)

Work history (12)：

2023/04 - 現在長崎医療センター脳神経外科医員
2021/04 - 現在 Nagasaki University Graduate School of Biomedical Sciences
2021/04 - 2023/03 佐世保市総合医療センター脳神経外科医長
2020/04 - 2021/03 長崎大学病院脳神経外科医員
2016/12 - 2020/03 社会医療法人北斗北斗病院脳神経外科医員

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