Kontani Kenji

コンタニケンジ | Kontani Kenji

Affiliation and department：
Job title：教授

Research field (1)： Functional biochemistry

Research keywords (3)：シグナル伝達 , 細胞内物質輸送 , Gタンパク質

Research theme for competitive and other funds (34)：

2023 - 2026 ARLファミリー低分子量Gタンパク質群の活性制御機構と生理的役割の解析
2020 - 2023 細胞小器官の機能動態に介在するARLファミリー低分子量Gタンパク質群の解析
2017 - 2020 Analysis of physiological function and activation mechanism of atypical small GTPases
2014 - 2018 Analysis of activation mechanism and physiological function of ARL family small GTPases
2011 - 2016 Analysis of the regulation and mode of action of atypical G-protein cycles

2011 - 2015 Analysis of atypical small GTPases involved in membrane dynamics

2011 - 2013 Arf-like GTPaseが介在する細胞内ロジスティクスと関連疾患

2010 - 2011 Screening and analysis of genes involved in regulation of lysosomal dynamics

2008 - 2010 Regulation of intracellular vesicle transport by small GTPase cycles

2008 - 2009 遺伝学的手法による上皮細胞の蛋白質選別輸送の解析

2005 - 2009 Functional analysis of atypical G proteins involved in cell signaling network

2007 - 2008 Comprehensive analysis of genes involved in the regulation of subcellular localization of drug transporters

2006 - 2007 細胞の増殖と分裂に介在する新奇低分子量G蛋白質群の機能解析

2006 - 2007 Membrane-Transport Signaling Involving the GTPase Cycle of G proteins

2005 - 2005 細胞の増殖と分裂に介在する新規低分子量G蛋白質群の機能解析

2001 - 2005 The structure and function of a novel G protein family regulating eukaryotic mRNA dynamics

2000 - 2004 G protein-dependent vectorial transportation of receptors, ion channels, and transporters

2000 - 2003 G蛋白質共役型及びFc受容体を介したマスト細胞のシグナル伝達機構

2001 - 2002 Identification of hepatic stem cells and development of its separation methods : Analysis of the self-replication and survival of the cells

2001 - 2001 低分子量G蛋白質Rab5の新しい役割:核内への機能分子輸送

2001 - 2001 新規G蛋白質による蛋白質間相互作用を介したmRNA動態の制御

2001 - 2001 がん細胞の増殖・転移におけるJNKシグナル系の役割

2001 - 2001 ATPアナログ認識可能な変異MAPキナーゼを利用したリン酸化基質の探索

2000 - 2001 Signal transduction mechanisms involved in mouse embryonic liver formation

2000 - 2001 Analysis of a novel GTP-binding protein GSPT involved in translational regulation

2000 - 2000 マウス免疫系におけるストレス応答性MAPキナーゼ系の機能解析

1999 - 2000 Physiological roles of cell surface ecto-enzymes

1999 - 2000 動物細胞におけるADPリボシル化反応の生理的役割と制御機構の解析

1999 - 1999 c-Junを活性化型に導くSAPK/JNKシグナル伝達系の個体レベルの解析

1999 - 1999 イノシトールリン脂質3キナーゼの分子多様性とそれらの活性化機構

1999 - 1999 マウス免疫系における新規ストレスシグナル分子SEK2/MKK7の機能解析

1999 - 1999 真核細胞のmRNA動態を制御する新しいGTP結合タンパク質

1998 - 1999 Analysis of the functions of G protein βγ-Subunit and application to drug design

1998 - 1999 Functions of the stress-signaling kinase SEK1 in mouse immune System and development

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Papers (79)：

Makoto Araki, Kenji Kontani. Analysis of the Guanine Nucleotide-Bound State of KRAS by Ion-Pair Reversed-Phase High-Performance Liquid Chromatography. Methods in molecular biology (Clifton, N.J.). 2024. 2797. 227-236
Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kino. Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2. Communications biology. 2023. 6. 1. 616-616
Makoto Araki, Kaho Yoshimoto, Meguri Ohta, Toshiaki Katada, Kenji Kontani. Development of a versatile HPLC-based method to evaluate the activation status of small GTPases. The Journal of biological chemistry. 2021. 297. 6. 101428-101428
Hirohisa Chiyoda, Masahiko Kume, Carla Cadena del Castillo, Kenji Kontani, Anne Spang, Toshiaki Katada, Masamitsu Fukuyama. Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis. PLOS Genetics. 2021. 17. 4. e1009457-e1009457
Makoto Araki, Kenji Kontani. Regulation of lysosomal positioning via TMEM55B phosphorylation. Journal of biochemistry. 2021

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MISC (22)：

清水光, 藤間祥子, 紺谷圏二, 堅田利明, 清水敏之. 新規グアニンヌクレオチド交換因子SmgGDSによるRhoA認識機構の構造基盤. 日本薬学会年会要旨集(CD-ROM). 2018. 138th
清水光, 藤間祥子, 紺谷圏二, 堅田利明, 清水敏之. Structural basis of RhoA recognition by novel guanine nucleotide exchange factor SmgGDS. 量子ビームサイエンスフェスタ(Web). 2018. 2017
清水光, 藤間祥子, 紺谷圏二, 堅田利明, 清水敏之. 新規グアニンヌクレオチド交換因子SmgGDSによるRhoA認識機構の構造基盤. Photon Factory News. 2018. 36. 2
清水光, 藤間祥子, 紺谷圏二, 堅田利明, 清水敏之. 新規グアニンヌクレオチド交換因子SmgGDSのX線結晶構造解析. 日本蛋白質科学会年会プログラム・要旨集. 2017. 17th
SAITOH Shin-Ichiroh, SAITOH Yoshiko M, SATO Katsuaki, KONTANI Kenji, MIYAKE Kensuke. ADP-libosylation factor-like 8b is required for pathogenesis of mouse models of Systemic Lupus Erythematosus. 日本免疫学会総会・学術集会記録(CD-ROM). 2017. 46

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Association Membership(s) (5)：

日本癌学会 , 日本薬学会 , 日本細胞生物学会 , 日本分子生物学会 , 日本生化学会

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