Kato Yuko

カトウユウコ | Kato Yuko

Affiliation and department：
Job title：特別協力研究員

Research field (1)： Hematology and oncology

Research keywords (4)： niche , 造血器腫瘍 , Mesenchymal stromal cells , Hematopoietic stem cells

Research theme for competitive and other funds (1)：

2022 - 2025 Phf6およびPhipによる骨髄ニッチを介した造血幹細胞制御機構の解明

Papers (12)：

Yuko Kato, Li-Bo Hou, Satoru Miyagi, Eriko Nitta, Kazumasa Aoyama, Daisuke Shinoda, Satoshi Yamazaki, Wakako Kuribayashi, Yusuke Isshiki, Shuhei Koide, et al. Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche. Experimental Hematology. 2019. 76. 24-37
Satoru Miyagi, Patrycja Sroczynska, Yuko Kato, Yaeko Nakajima-Takagi, Motohiko Oshima, Ola Rizq, Naoya Takayama, Atsunori Saraya, Seiya Mizuno, Fumihiro Sugiyama, et al. The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells. Blood. 2019. 133. 23. 2495-2506
Kazumasa Aoyama, Motohiko Oshima, Shuhei Koide, Emi Suzuki, Makiko Mochizuki-Kashio, Yuko Kato, Shiro Tara, Daisuke Shinoda, Nobuhiro Hiura, Yaeko Nakajima-Takagi, et al. Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome. iScience. 2018. 9. 161-174
Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, et al. Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition. Clinical Cancer Research. 2017. 23. 16. 4817-4830
Y Nishida, A Maeda, M J Kim, L Cao, Y Kubota, J Ishizawa, A AlRawi, Y Kato, A Iwama, M Fujisawa, et al. The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. Blood Cancer Journal. 2017. 7. 2. e527-e527

ｍore...

MISC (1)：

Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Anqi Ma, et al. Molecular Mechanism behind the Synergistic Activity of Proteasome Inhibition and PRC2 Inhibition in the Treatment of Multiple Myeloma. BLOOD. 2016. 128. 22

Lectures and oral presentations (3)：

Bmi1 restricts the adipogenic differentiation of mesenchymal stromal cells to maintain the integrity of the hematopoietic stem cell niche
(2019)
造血幹細胞ニッチにおけるBmi1の機能解析
(第40回日本炎症・再生医学会 2019)
The polycomb protein Bmi1 restrains perivascular mesenchymal stromal cells from adipogenic differentiation to maintain the integrity of hematopoietic stem cell niche
(2018)

Education (3)：

2003 - 2007 東京大学大学院医学系研究科病因病理学専攻博士課程
2001 - 2003 筑波大学大学院医科学研究科医科学専攻修士課程
1997 - 2001 東邦大学理学部生物学科

Work history (4)：

2018/04 - 現在島根大学医学部生命科学講座特別協力研究員
2015/04 - 2018/03 千葉大学大学院医学研究院細胞分子医学特別研究員
2009/04 - 2012/09 理化学研究所バイオリソースセンター細胞材料開発室特別研究員
2007/04 - 2009/03 株式会社ステリック再生医科学研究所研究員

Awards (1)：

2005/12 - 公益信託日本白血病研究基金一般研究KYO賞

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