Watanabe Miho

ワタナベミホ | Watanabe Miho

Affiliation and department：
Job title：助教
Research theme for competitive and other funds (21)：

2023 - 2026 ストレスがGABAニューロンを介して生殖機能を抑制するメカニズムの解明
2020 - 2023 排卵や卵胞成熟を引き起こすGnRHニューロンの周期的活動のメカニズムの解明
2020 - 2022 細胞内クロライドホメオスタシス破綻がてんかんを引き起こすメカニズムの解明
2016 - 2020 ストレスによる生殖機能低下をおこすGnRHニューロンへのGABA入力の可塑的変化
2017 - 2019 Developmental disorder model based on fetal hypothalamic GABA-Cl system disturbances

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Papers (36)：

Miho Watanabe, Adya Saran Sinha, Yohei Shinmyo, Atsuo Fukuda. Early establishment of chloride homeostasis in CRH neurons is altered by prenatal stress leading to fetal HPA axis dysregulation. Frontiers in Molecular Neuroscience. 2024. 17. 1373337
Trong Dao Nguyen, Masaru Ishibashi, Adya Saran Sinha, Miho Watanabe, Daisuke Kato, Hiroshi Horiuchi, Hiroaki Wake, Atsuo Fukuda. Astrocytic NKCC1 inhibits seizures by buffering Cl- and antagonizing neuronal NKCC1 at GABAergic synapses. Epilepsia. 2023. 64. 12. 3389-3403
Yashuang Ping, Kenji Ohata, Kenji Kikushima, Takumi Sakamoto, Ariful Islam, Lili Xu, Hengsen Zhang, Bin Chen, Jing Yan, Fumihiro Eto, et al. Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain. Biomolecules. 2023. 13. 5. 784
Egawa K, Watanabe M, ute, ually to this work, Shiraishi H, Sato D, Takahashi Y, Nishio S, Fukuda A. Imbalanced expression of cation-chloride cotransporters as potential therapeutic target in an Angelman syndrome model mouse. Scientific Reports. 2023. 13. 5685
Yasushi Hosoi, Tenpei Akita, Miho Watanabe, Takashi Ito, Hiroaki Miyajima, Atsuo Fukuda. Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II/III pyramidal neurons. Frontiers in Molecular Neuroscience. 2022. 15. 806798-806798

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MISC (13)：

福田敦夫, 秋田天平, 渡部美穂, 石橋賢. Roles of WNK Signaling Pathway in the Central Nervous System Development and Function. ソルト・サイエンス研究財団助成研究報告集 2 医学食品科学編. 2021. 2019
福田敦夫, 秋田天平, 渡部美穂, 武藤弘樹, 秦健一郎. Influence of Maternal High Salt Diet on Fetal Brain Development Via Osmotic and Na, Cl Modulators. ソルト・サイエンス研究財団助成研究報告集 2 医学食品科学編. 2019. 2017
HOSOI Yasushi, AKITA Tenpei, WATANABE Miho, MUTOH Hiroki, MIYAJIMA Hiroaki, FUKUDA Atsuo. Taurine depletion reduces postsynaptic GABA_A receptors in layer 2/3 pyramidal neurons of the somatosensory cortex. Journal of Physiological Sciences. 2017. 67. Supplement 1
Hiroyuki Inade, Miho Watanabe, Taku Uchida, Atsuo Fukuda, Yuchio Yanagawa, Junichi Nabekura. Amibient GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S32-S32
Miho Watanabe, Junichi Nabekura. Conditional expression of KCC2 in GnRH neurons in vivo causes impairment of fertility. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S218-S218

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Books (1)：

Lectures and oral presentations (111)：

Astrocytic Na-K-Cl cotransporter type1 attenuates seizures promoted by GABAergic excitation.
(2023)
Effects of enhanced KCC2 activity induced by dephosphorylation of Thr906 and Thr1007 on neuronal function.
(2023)
Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II/III pyramidal neurons.
(2023)
抑制性神経伝達におけるカリウム-クロライド共輸送体(KCC2)のリン酸化による機能制御の役割
(第49回日本脳科学会 2022)
Loss of astrocytic Na-K-Cl cotransporter type 1 hastens seizures promoted by GABAergic excitation of neurons.
(2022)

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Education (3)：

Work history (4)：

2012/08 - 現在 Hamamatsu University School of Medicine
2011/03 - 2012/07 群馬大学テニュアトラックプログラム「若手先端科学研究者の研究環境改革」先端科学研究指導者育成ユニット先端医学・生命科学研究チーム助教
2006/04 - 2011/03 自然科学研究機構生理学研究所発達生理学研究系生体恒常機能発達機構研究部門特任助教
2004/04 - 2006/03 自然科学研究機構生理学研究所発達生理学研究系生体恒常機能発達機構研究部門非常勤研究員

Association Membership(s) (5)：

国際タウリン研究会 , 日本脳科学会 , Society for Neuroscience , 日本神経科学学会 , 日本生理学会

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