Higa Kazunari

ヒガカズナリ | Higa Kazunari

Affiliation and department：

Research field (1)： Ophthalmology

Research theme for competitive and other funds (6)：

2023 - 2026 Establishment of experimental basis to improve the prognosis of corneal transplantation in treating bullous keratoplasty due to pathological aqueous humor.
2020 - 2023 Proposal of a novel therapy for bullous keratopathy based on human-derived multiomics analysis
2016 - 2019 Effect of human oral mucosa mesenchymal cells in ocular surface model
2014 - 2017 The relationship between the amniotic and mesenchymal stem cell, the its effect and preservation
2008 - 2009 Wound healing model of corneal epithelium using stenless-ring.

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Papers (78)：

Asahi Kitamura, Masahito Yamamoto, Hidetomo Hirouchi, Genji Watanabe, Shuichiro Taniguchi, Sayo Sekiya, Satoshi Ishizuka, Juhee Jeong, Kazunari Higa, Shuichiro Yamashita, et al. Downregulation of SOX9 expression in developing entheses adjacent to intramembranous bone. PLOS ONE. 2024. 19. 5. e0301080-e0301080
Kazunari Higa, Reona Kimoto, Takashi Kojima, Murat Dogru, Wolfgang G. K. Müller-Lierheim, Jun Shimazaki. Therapeutic Aqueous Humor Concentrations of Latanoprost Attained in Rats by Administration in a Very-High-Molecular-Weight Hyaluronic Acid Eye Drop. Pharmaceutics. 2024. 16. 4. 523-523
Saki Sakakura, Emi Inagaki, Yuichiro Ochiai, Masatoshi Yamamoto, Naofumi Takai, Taeko Nagata, Kazunari Higa, Yasunori Sato, Hiroshi Toshida, Dogru Murat, et al. A Comprehensive Assessment of Tear-Film-Oriented Diagnosis (TFOD) in a Dacryoadenectomy Dry Eye Model. International journal of molecular sciences. 2023. 24. 22
Hikari Amemiya, Masahito Yamamoto, Kazunari Higa, Genji Watanabe, Shuichiro Taniguchi, Kei Kitamura, Juhee Jeong, Nobuaki Yanagisawa, Ken-ichi Fukuda, Shinichi Abe. Effects of Myostatin on Nuclear Morphology at the Myotendinous Junction. International Journal of Molecular Sciences. 2023. 24. 7. 6634-6634
Murat Dogru, Takashi Kojima, Kazunari Higa, Ayako Igarashi, Haruka Kudo, Wolfgang G. K. Müller-Lierheim, Kazuo Tsubota, Kazuno Negishi. The Effect of High Molecular Weight Hyaluronic Acid and Latanoprost Eyedrops on Tear Functions and Ocular Surface Status in C57/BL6 Mice. Journal of Clinical Medicine. 2023. 12. 2. 544-544

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MISC (30)：

KOUNO Michiyoshi, INADA Junichiro, MINABE Masaki, AKIYAMA Yurie, HIGA Kazunari, TACHIKAWA Tetsuhiko, NOMURA Takeshi, TAKAHASHI Shinichi. Desmoglein 3 changes gene expression profiles in oral squamous cell carcinoma between anchorage-dependent and -independent conditions. 日本研究皮膚科学会年次学術大会・総会プログラム. 2022. 47th
KOUNO Michiyoshi, INADA Junichiro, MINABE Masaki, AKIYAMA Yurie, HIGA Kazunari, TACHIKAWA Tetsuhiko, NOMURA Takeshi, TAKAHASHI Shinichi. Two opposite effects of desmoglein 3 on the growth of oral squamous cell carcinoma between anchorage-dependent and -independent conditions. 日本研究皮膚科学会年次学術大会・総会プログラム. 2021. 46th
三邉正樹, 秋山友理恵, 比嘉一成, 高橋愼一, 河野通良, 野村武史. 口腔扁平上皮癌におけるデスモグレイン3と上皮成長因子受容体の潜在的相関とそのセツキシマブ治療効果に対する影響. 歯科学報. 2019. 119. 5. 413-420
Kazunari Higa, Hideyuki Miyashita, Jun Shimazaki, Kazuo Tsubota, Shigeto Shimmura. Spheroidal cultivation of the human limbal epithelial niche from small limbal tissue. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016. 57. 12
Yoshiyuki Satake, Kazunari Higa, Murat Dogru, Takefumi Yamaguchi, Jun Shimazaki. Rebamipide enhances the barrier function of human conjunctival epithelium. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016. 57. 12

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Lectures and oral presentations (11)：

Cornea-derived organoid transplantation in rabbit limbal deficiency model.
(2024)
Cornea-derived organoid transplantation in rabbit limbal deficiency model.
(2024)
ヒト羊膜fibroblasts由来細胞外小胞体の分離と角膜上皮への効果
(第22回日本再生医療学会 2023)
ヒト羊膜由来線維芽細胞から分離した細胞外小胞体の角膜上皮への効果
(角膜カンファランス2023 2023)
ヒト角膜輪部オルガノイド培養におけるメチルセルロースの応用
(第20回日本再生医療学会総会)

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Professional career (1)：

博士(獣医学) (麻布大学)

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