Rchr
J-GLOBAL ID：202001014278343852
Update date: Jan. 30, 2024
AKI ISIYAMA
イシヤマ アキ | AKI ISIYAMA
Affiliation and department：
Job title：
Assistant Professor
Research field (2)：
Parasitology
, Pharmaceuticals - chemistry and drug development
Research keywords (6)：
リーシュマニア 作用機序
, バベシア
, トリパノソーマ
, マラリア
, antiprotozoal compounds malaria Trypanosoma Babesia Leishmania mode of action
, 抗原虫剤
Research theme for competitive and other funds (3)：
- 2020 - 2023 Identification of the anti-protozoal compound binding protein for the development and application of novel drug targets.
- 2017 - 2020 Identification of the anti-protozoal compound binding protein for the development of novel drug targets.
- 2014 - 2017 Screening of Plasmodium falciparum enoyl-Acyl carrier protein reductase (PfFabI) inhibitors from microbial metabolites for prophylaxis and blocking transmission of malaria
Papers (52)：
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Ishiyama A, Iwatsuki M, Hokari R, Sawa M, Ōmura S, Otoguro K. Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo. J. Antibiot. 2015
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Inahashi Y, Iwatsuki M, Ishiyama A, Matsumoto A, Hirose T, Oshita J, Sunazuka T, Panbangred W, Takahashi Y, Kaiser M, et al. Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, Actinoallomurus fulvus MK10-036. Org Lett. 2015. 17. 864-867
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Ishiyama A, Iwatsuki M, Yamamoto T, Miura H, Omura S, Otoguro K. Antimalarial tropones and their Plasmodium falciparum glyoxalase I (pfGLOI) inhibitory activity. J. Antibiot. 2014. 67. 545-547
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Aoyagi Y, Fujiwara K, Yamazaki A, Sugawara N, Yano R, Fukaya H, Hitotsuyanagi Y, Takeya K, Ishiyama A, Iwatsuki M, et al. Semisynthesis of salviandulin E analogues and their antitrypanosomal activity. Bioorganic & Medicinal Chemistry Letters. 2014. 24. 442-446
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Aoyagi Y, Fujiwara K, Yamazaki A, Sugawara N, Yano R, Fukaya H, Hitotsuyanagi Y, Takeya K, Ishiyama A, Iwatsuki M, et al. Semisynthesis of salviandulin E analogues and their antitrypanosomal activity. Bioorg Med Chem Lett. 2013. 24. 442-446
ｍore...
Lectures and oral presentations (28)：
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微生物代謝産物からのマラリア脂肪酸合成酵素pfFabI阻害物質の探索
(日本農芸化学会2015年度大会 2015)
-
キナーゼ阻害薬の抗マラリア活性
(日本薬学会第135年会 2015)
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Antimalarial tropones: possibility of Plasmodium falciparum glyoxalase I (pfGLOI) inhibitor.
(第55回日本熱帯医学会大会、第29回日本国際保健医療学会学術大会 合同大会 2014)
-
微生物代謝産物由来の抗トリパノソーマ原虫活性物質の探索研究(3)
(HealthThe 54th Annual Scientific Meeting forThe Japanese Society of Tropical MedicineProgram 2013)
-
Elucidation of action mechanism and active ingredients of traditional Japanese herbal (Kampo) medicines and useful utilization of the resulting knowledge
(2nd Mahidol University-Kitasato University Joint Symposium -Natural Products and Biodiversity- 2012)
ｍore...
Works (1)：
-
マラリア治療薬シードの探索研究
岩月正人, 石山亜紀, 穂苅 玲, 乙黒一彦, 廣瀬友靖, 砂塚敏明, 松本厚子, 野中健一, 塩見和朗, 清原寛章, 大村 智, 多賀政晴, 飯島 肇, 渡辺憲明 2014 - 2014
Education (1)：
- 1992 - 1996 Tokyo University of Agriculture Graduate School, Division of Agriculture
Professional career (1)：
Work history (6)：
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