Komatsu Toshimitsu

コマツトシミツ | Komatsu Toshimitsu

Affiliation and department：
Job title：技術職員

Research field (1)： Experimental pathology

Research keywords (7)： Wdr6 , anti tumor , metabolism , Mitochondria , FoxOs , Aging , Calorie restriction

Research theme for competitive and other funds (8)：

2021 - 2024 A mechanism underlying the inhibition of steatohepatitis via FoxO3
2017 - 2019 Functional analysis of inflammation-related microRNA in non-alcoholic steatohepatitis and antisense oligodeoxynucleotide development
2016 - 2019 Analysis the aging mechanisms via WDR6 and aim for building new animal aging model
2016 - 2019 Comprehensive analysis for wound inflammation-related miRNAs and development of novel therapies
2015 - 2019 Regulation of cancer and aging by FoxO and investigation of compounds for regulation of FoxO

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Papers (46)：

Seongjoon Park, Toshimitsu Komatsu, Hiroko Hayashi, Ryoichi Mori, Isao Shimokawa. The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis. Biomedicines. 2021. 9. 11. 1739-1739
Seongjoon Park, Erkhembayar Nayantai, Toshimitsu Komatsu, Hiroko Hayashi, Ryoichi Mori, Isao Shimokawa. NPY Deficiency Prevents Postmenopausal Adiposity by Augmenting Estradiol-Mediated Browning. The journals of gerontology. Series A, Biological sciences and medical sciences. 2020. 75. 6. 1042-1049
Zi Wang, Toshimitsu Komatsu, Yoshihisa Ohata, Yukari Watanabe, Yiwen Yuan, Yuki Yoshii, Seongjoon Park, Ryoichi Mori, Motoyasu Satou, Yoshitaka Kondo, et al. Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice. Geriatrics & gerontology international. 2020. 20. 3. 238-247
Toshimitsu Komatsu, Seongjoon Park, Hiroko Hayashi, Ryoichi Mori, Haruyoshi Yamaza, Isao Shimokawa. Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction. Nutrients. 2019. 11. 12
Maiko de Kerckhove, Katsuya Tanaka, Takahiro Umehara, Momoko Okamoto, Sotaro Kanematsu, Hiroko Hayashi, Hiroki Yano, Soushi Nishiura, Shiho Tooyama, Yutaka Matsubayashi, et al. Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds. EMBO molecular medicine. 2018. 10. 10

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MISC (4)：

I. Shimokawa, T. Chiba, R. Mori, T. Komatsu. NECESSITY OF NEUROPEPTIDE Y FOR THE EFFECT OF DIETARY RESTRICTION IN MICE. GERONTOLOGIST. 2012. 52. 152-152
HAYASHI H., YAMAZA H., TOU K., TOUYAMA H., KOMATSU T., CHIBA T., HIGAMI Y., SHIMOKAWA I. Glucose metabolism in calorie-restricted or transgenic dwarf rat : Analysis of adiponectin-AMPK pathway. 2005. 29. 3. 31-34
Shimokawa, I, T Komatsu, H Yamaza, T Chiba, Y Higami. Stress response in a transgenic dwarf rat model: relation to calorie restriction. FASEB JOURNAL. 2005. 19. 5. A1051-A1051
Shimokawa, I, T Komatsu, K Tou, H Touyama, T Chiba, H Yamaza, Y Higami. Effect of leptin on gene expression in hypothalamus of calorie restricted rats. JOURNAL OF NEUROCHEMISTRY. 2003. 87. 13-13

Education (2)：

2002 - 2006 Nagasaki University Graduate School of Biomedical Sciences
1998 - 2000 Hokkaido University Graduate School of Agriculture Department of Applied Bioscience

Work history (2)：

2000/11 - 現在 Nagasaki University Graduate School of Biomedical Sciences Research engineer
2007/03 - 2009/03 National Institute on Aging Genomics Unit, Laboratory of Experimental Gerontology Visiting Fellow

Awards (2)：

2017/06 - 日本老年学会第30回日本老年学会総会合同ポスター賞 The role of FoxO3a in liver of calorie restriction in mice
2012/06 - 日本抗加齢医学会第12回日本抗加齢医学会総会優秀演題カロリー制限の抗腫瘍効果と寿命延長効果におけるFoxO1の役割

Association Membership(s) (2)：

日本基礎老化学会 , 日本抗加齢医学会

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