Research keywords (4)：
超解像顕微鏡
, 光学顕微鏡
, 分子モーター
, 1分子計測
Research theme for competitive and other funds (7)：
2022 - 2025 分子の揺らぎを邪魔しない小さな標識を用いた高速1分子顕微鏡の開発
2022 - 2025 超解像・一分子イメージングによる微小管内腔結合タンパク質の解析
2019 - 2024 情報物理学でひもとく生命の秩序と設計原理
2019 - 2024 ゆらぎと応答の基本限界から探索する生体分子の設計原理
2019 - 2022 神経軸索での小胞輸送速度が速いのはなぜか?
2019 - 2021 細胞内1分子動態計測のための新規構造化照明超解像顕微鏡の開発
2012 - 2013 熱ゆらぎを有効利用した分子モーターの機能発現機構の解析
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Papers (35)：
Hiroki Fukunaga, Takumi Washio, Keisuke Fujita, Masashi Ohmachi, Hiroaki Takagi, Keigo Ikezaki, Toshio Yanagida, Mitsuhiro Iwaki. Dynamic coordination of the lever-arm swing of human myosin II in thick filaments on actin. 2023
Hitomi Matsubara, Hiroki Fukunaga, Takahiro Saito, Keigo Ikezaki, Mitsuhiro Iwaki. A Programmable DNA Origami Nanospring That Reports Dynamics of Single Integrin Motion, Force Magnitude and Force Orientation in Living Cells. ACS nano. 2023
Shoko Fujimura, Kazuhiro Mio, Masahiro Kuramochi, Hiroshi Sekiguchi, Keigo Ikezaki, Muneyo Mio, Kowit Hengphasatporn, Yasuteru Shigeta, Tai Kubo, Yuji C. Sasaki. Agonist and Antagonist-Diverted Twisting Motions of a Single TRPV1 Channel. The Journal of Physical Chemistry B. 2020. 124. 51. 11617-11624
Keisuke Fujita, Masashi Ohmachi, Keigo Ikezaki, Toshio Yanagida, Mitsuhiro Iwaki. Direct visualization of human myosin II force generation using DNA origami-based thick filaments. Communications biology. 2019. 2. 437-437
Sekiguchi, Hiroshi, Kuramochi, Masahiro, Ikezaki, Keigo, Okamura, Yu, Yoshimura, Kazuki, Matsubara, Ken, Chang, Jae-Won, Ohta, Noboru, Kubo, Tai, Mio, Kazuhiro, et al. Diffracted X-ray Blinking Tracks Single Protein Motions. SCIENTIFIC REPORTS. 2018. 8. 1. 17090-17090
Y. C. Sasaki, K. Ikezaki, K. Mio, H. Sekiguchi. New X-ray single molecular observations from super-Poisson distribution using laboratory X-rays. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S192-S192
K. Mio, K. Ikezaki, H. Sekiguchi, T. Baba, Y. Matsushita, T. Kubo, Y. C. Sasaki. Asymmetric rotational brownian motion on TRPV1 cation channel with X-ray single molecule technique. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S267-S267
T. Kubo, T. Baba, S. Ohashi, H. Inagaki, K. Ikezaki, K. Mio, H. Sekiguchi, Y. C. Sasaki. PAMs modulate molecular dynamics of nAChR alpha 7: direct observation by DXT and electrophysiology. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S165-S165
Keigo Ikezaki, Ken Matsubara, Yufuku Matsushita, Chang Jaewon, Hiroshi Sekiguchi, Yuji C. Sasaki. A New Technique for Molecular Dynamics Observation using Laboratory X-Ray Source. BIOPHYSICAL JOURNAL. 2017. 112. 3. 579A-579A
Yuji C. Sasaki, K. Ikezaki, N. Ohta, H. Sekiguchi. New X-Ray Single Molecular Methodology using a Normal Monochromatic X-Ray. BIOPHYSICAL JOURNAL. 2017. 112. 3. 579A-579A
