DAN TAKASHI

ダンタカシ | DAN TAKASHI

Research theme for competitive and other funds (2)：

2017 - 2019 Elucidation of the new control mechanism of aging through PAI-1
2012 - 2015 The development of a novel mechanism therapeutic drug for rare intractable inflammatory diseases

Papers (47)：

Shinobu Hirai, Hideki Miwa, Tomoko Tanaka, Kazuya Toriumi, Yasuto Kunii, Hiroko Shimbo, Takuya Sakamoto, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, et al. High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice. Science advances. 2021. 7. 46. eabl6077
Kazuya Toriumi, Stefano Berto, Shin Koike, Noriyoshi Usui, Takashi Dan, Kazuhiro Suzuki, Mitsuhiro Miyashita, Yasue Horiuchi, Akane Yoshikawa, Mai Asakura, et al. Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex. Redox Biology. 2021. 45. 102057-102057
Shin Koike, Kazuya Toriumi, Sakura Kasahara, Yosuke Kibune, Yo-Ichi Ishida, Takashi Dan, Toshio Miyata, Makoto Arai, Yuki Ogasawara. Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits. Antioxidants (Basel, Switzerland). 2021. 10. 4
Kazuya Toriumi, Stefano Berto, Shin Koike, Noriyoshi Usui, Takashi Dan, Kazuhiro Suzuki, Mitsuhiro Miyashita, Yasue Horiuchi, Akane Yoshikawa, Yuki Sugaya, et al. Impairment of methylglyoxal detoxification systems causes mitochondrial dysfunction and schizophrenia-like behavioral deficits. 2020
Shinichiro Hosaka, Tetsuya Yamada, Kei Takahashi, Takashi Dan, Keizo Kaneko, Shinjiro Kodama, Yoichiro Asai, Yuichiro Munakata, Akira Endo, Hiroto Sugawara, et al. Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance. Frontiers in pharmacology. 2020. 11. 943-943

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MISC (22)：

段孝, 内田渡, 平塚秀明, 大島吉輝, 宮田敏男. 【tPAの適応拡大の取り組みと新しい線溶制御薬】PAI-1阻害剤の新展開がん治療への臨床応用. 日本血栓止血学会誌. 2018. 29. 5. 487-494
段孝, 宮田敏男. 線溶系研究の新展開2017-18(第4回) PAI-1阻害薬の展望. Thrombosis Medicine. 2018. 8. 1. 67-70
山岡長寿, 村埜賢司, 前田彰久, 目黒寛司, 段孝, 宮田敏男. 経口吸収性に優れたPAI-1阻害薬の創出新規N-アシルアントラニル酸誘導体の構造最適化研究. 日本薬学会年会要旨集. 2018. 138年会. 2. 186-186
Aobulikasimu Alkebaier, 金光文, 朴金瑛, Zulipiya Aibibula, 段孝, 市村敦彦, 宮田敏男, 越智広樹, 佐藤信吾, 大川淳, et al. 新規PAI-1阻害剤はマウス骨髄除去モデルにおいて骨形成を促進する. 日本整形外科学会雑誌. 2017. 91. 8. S1568-S1568
金光文, 朴英瑛, Aobulikasimu Alkebaier, Zulipiya Aibibula, 段孝, 市村敦彦, 赤堀浩司, 宮田敏男, 越智広樹, 佐藤信吾, et al. 新規PAI-1阻害薬は閉経後骨粗鬆症モデルの骨密度を回復させる. 日本整形外科学会雑誌. 2017. 91. 8. S1711-S1711

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