Yokoi Yuki

ヨコイユウキ | Yokoi Yuki

Affiliation and department：
Job title： Assistant Professor

Research field (2)： Cell biology , Immunology

Research keywords (11)：炎症性腸疾患 , 生活習慣病 , 食と健康 , 腸内環境 , エンテロイド , 自然免疫 , 抗菌ペプチド , 腸内細菌 , 幹細胞 , 腸管粘膜免疫 , Paneth細胞

Research theme for competitive and other funds (3)：

2021 - 2024 Paneth細胞分泌メカニズムから紐解く腸管粘膜免疫システムの解明
2021 - 2022 細胞内カルシウム可視化エンテロイドによる食機能評価系の樹立
2019 - 2021 食と腸内細菌によるPaneth細胞分泌メカニズムからみた腸内環境ネットワーク

Papers (18)：

Sakura YONOICHI, Yukako HARA, Yuya ISHIDA, Asuka SHODA, Mako KIMURA, Midori MURATA, Sarika NUNOBIKI, Makiko ITO, Ayano YOSHIMOTO, Youhei MANTANI, et al. Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice. Journal of Veterinary Medical Science. 2024
Li Gan, Yuga Inamura, Yu Shimizu, Yuki Yokoi, Yuki Ohnishi, Zihao Song, Yasuhiro Kumaki, Takashi Kikukawa, Makoto Demura, Masaaki Ito, et al. A Basic Study of the Effects of Mulberry Leaf Administration to Healthy C57BL/6 Mice on Gut Microbiota and Metabolites. Metabolites. 2023. 13. 9. 1003-1003
Yi Wang, Yuchi Song, Shaonan Yan, Rina Hiramine, Yuki Ohnishi, Yuki Yokoi, Kiminori Nakamura, Takashi Kikukawa, Tokiyoshi Ayabe, Tomoyasu Aizawa. Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions. Antibiotics. 2023. 12. 6. 1047-1047
Zihao Song, Yuki Ohnishi, Seiji Osada, Li Gan, Jiaxi Jiang, Zhiyan Hu, Hiroyuki Kumeta, Yasuhiro Kumaki, Yuki Yokoi, Kiminori Nakamura, et al. Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis. Metabolites. 2023. 13. 5. 611-611
Yu Shimizu, Ryodai Yamamura, Yuki Yokoi, Tokiyoshi Ayabe, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Akihiro Imae, Takafumi Nakagawa, Akiko Tamakoshi, et al. Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production. Gut Microbes. 2023. 15. 1

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Lectures and oral presentations (16)：

Selective Paneth cell granule secretion in response to pathogenic and commensal bacteria in enteric mucosal immunity
(The 52nd Annual Meeting of the Japanese Society for Immunology 2024)
Establishment of a high-efficient method for generating transgenic enteroid revealing intestinal epithelial function
(The 46th Annual Meeting of the Molecular Biology Society of Japan 2023)
病原菌と共生菌に対する選択的なPaneth細胞顆粒分泌調節による自然免疫と共生のメカニズム
(令和4年度北大細胞生物研究集会 2023)
Regulation of Paneth cell granule secretion by selective sensing of pathogenic and commensal bacteria in intestinal homeostasis
(2022)
The mechanism of acetylcholine-induced Paneth cell secretory responses in innate enteric immunity
(The 50th Annual Meeting of the Japanese Society for Immunology 2021)

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Education (2)：

2015 - 2020 Hokkaido University Graduate School of Life Science
2010 - 2015 Hokkaido University School of Science Biological Sciences

Professional career (1)：

Doctor of Life Science (Hokkaido University)

Work history (4)：

2023/07 - 現在北海道大学大学院先端生命科学研究院助教
2021/04 - 2023/06 北海道大学大学院先端生命科学研究院特任助教
2020/04 - 2021/03 JSPS research fellow
2019/04 - 2020/03 JSPS research fellow

Awards (2)：

2021/11 - 第17回日本食品免疫学会学術大会ポスター賞
2016/11 - 第12回日本食品免疫学会学術大会ポスター賞

Association Membership(s) (5)：

Japanese Association for Laboratory Animal Science , The Intestinal Microbiology Society , Japanese Association for Food Immunology , Japanese Society for Immunology , The Molecular Biology Society of Japan

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