Ishigaki Kazuyoshi

イシガキカズヨシ | Ishigaki Kazuyoshi

Affiliation and department：
Job title： Team Leader

Research keywords (3)： Genome wide association study , 免疫学 , 機能遺伝学

Research theme for competitive and other funds (3)：

2023 - 2026 老化細胞の蓄積を起因とするループス腎炎の病態形成と治療標的分子の解明
2022 - 2025 自己免疫疾患のリスク多型機能解析による個別化抗サイトカイン療法の確立
2021 - 2023 自己免疫疾患のリスク多型の機能を制御する転写因子の探索

Papers (98)：

Kazuhiko Yamamoto, Kazuyoshi Ishigaki, Yukinori Okada. How can genetics analysis allow for early detection of rheumatoid arthritis. Seminars in Arthritis and Rheumatism. 2024. 64. 152323-152323
Saori Sakaue, Saisriram Gurajala, Michelle Curtis, Yang Luo, Wanson Choi, Kazuyoshi Ishigaki, Joyce B Kang, Laurie Rumker, Aaron J Deutsch, Sebastian Schönherr, et al. Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease. Nature protocols. 2023
Mineto Ota, Masahiro Nakano, Yasuo Nagafuchi, Satomi Kobayashi, Hiroaki Hatano, Ryochi Yoshida, Yuko Akutsu, Takahiro Itamiya, Nobuhiro Ban, Yumi Tsuchida, et al. Multimodal repertoire analysis unveils B cell biology in immune-mediated diseases. Annals of the Rheumatic Diseases. 2023. ard-2023
Saeko Yamada, Yasuo Nagafuchi, Min Wang, Mineto Ota, Hiroaki Hatano, Yusuke Takeshima, Mai Okubo, Satomi Kobayashi, Yusuke Sugimori, Nakano Masahiro, et al. Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance. Annals of the rheumatic diseases. 2023. 82. 6. 809-819
Shohei Kojima, Satoshi Koyama, Mirei Ka, Yuka Saito, Erica H Parrish, Mikiko Endo, Sadaaki Takata, Misaki Mizukoshi, Keiko Hikino, Atsushi Takeda, et al. Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk. Nature genetics. 2023. 55. 6. 939-951

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MISC (34)：

Kazuyoshi Ishigaki, Saori Sakaue, Chikashi Terao, Yang Luo, Kyuto Sonehara, Kensuke Yamaguchi, Tiffany Amariuta, Chun Lai Too, Vincent A Laufer, Ian C Scott, et al. Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis. medRxiv. 2021
Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, et al. Meta-analysis of 208,370 East Asians identifies 113 genomic loci and yields new non-immune cell relevant biological insights for systemic lupus erythematosus. medRxiv. 2020
Masaru Koido, Chung-Chau Hon, Satoshi Koyama, Hideya Kawaji, Yasuhiro Murakawa, Kazuyoshi Ishigaki, Kaoru Ito, Jun Sese, Yoichiro Kamatani, Piero Carninci, et al. Predicting cell-type-specific non-coding RNA transcription from genome sequence. bioRxiv. 2020
土屋遥香, 太田峰人, 住友秀次, 石垣和慶, 鈴木亜香里, 高地雄太, 土田優美, 庄田宏文, 乾洋, 武冨修治, et al. 自己免疫疾患のメカニズムへの最新のアプローチ関節リウマチ患者由来滑膜線維芽細胞の統合的機能ゲノム解析. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2019. 63回. 202-202
土田優美, 太田峰人, 太田峰人, 石垣和慶, 石垣和慶, 住友秀次, 山口健介, 永渕泰雄, 土屋遥香, 庄田宏文, et al. 刺激下でのCD4陽性T細胞におけるexpression quantitative trait locusの検討. 日本臨床免疫学会総会プログラム・抄録集. 2019. 47th

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Education (2)：

2010 - 2014 東京大学大学院医学系研究科(アレルギー・リウマチ学)
1999 - 2005 東京大学医学部医学科

Professional career (1)：

医学博士 (東京大学)

Work history (9)：

2021/04 - 現在 RIKEN Center for Integrative Medical Sciences Laboratory for Human Immunogenetics
2018/06 - 2021/03 Broad Institute
2018/06 - 2021/03 Harvard Medical School
2018/06 - 2021/03 Brigham And Women's Hospital, Department of Medicine, Division of genetics and rheumatology
2016/04 - 2018/05 理化学研究所・統合生命医科学研究センター(統計解析研究チーム)

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Awards (2)：

2018/06 - 日本骨免疫学会奨励賞
2018/04 - 日本リウマチ学会奨励賞

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