Rchr
J-GLOBAL ID：202001015850591109
Update date: Sep. 03, 2024
Izu Yayoi
イズ ヤヨイ | Izu Yayoi
Affiliation and department：
Research field (5)：
Orthopedics
, Sports science
, Cell biology
, Laboratory animal science
, Morphology, anatomy
Research keywords (1)：
Extracellular Matrix, Collagens, tendons and Ligaments. Bone
Research theme for competitive and other funds (16)：
- 2023 - 2027 Elucidation of early bone tissue construction through biological volume image analysis - from both cell and bone matrix perspectives -
- 2023 - 2027 Elucidation of early bone tissue architecture by in vivo volumetric image analysis-from both sides of cells and bone matrix
- 2022 - 2027 Elucidation of regulatory mechanisms of tendon homeostasis via tenocyte network.
- 2021 - 2023 FACITタイプ12型コラーゲンによる運動器制御機構の解明
- 2019 - 2022 The role of Collagen 6 in knee anterior cruciate ligament
- 2018 - 2021 Elucidation of collagen XII regulatory role in osteoarthritis
- 2021 - 小児希少疾患であるミオパチー型エーラス・ダンロス症候群のエネルギー代謝機構をターゲットとした治療法の開発
- 2014 - 2018 Molecular Mechanism of Comprehensive Signal for Bone Formation
- 2015 - 2017 Elucidation of novel bone matrix regulatory system by collagens VI and XII.
- 2017 - Regulation of muscle-tendon-bone networks in locomotive syndrome.
- 2017 - Identification of sarcopenia marker
- 2017 - interactive regulation of collagens VI and XII causing Ullrich congenital muscular dystrophy in musculoskeletal system,
- 2014 - 2015 細胞外基質蛋白質による骨芽細胞動態制御の分子メカニズムの解明
- 2015 - Elucidation of cell competition mechanism in terminal differentiation of osteoblasts
- 2015 - Elucidation of mechanosensing mechanisms in musculoskeletal system.
- 2015 - non-fibrillar collagens regulation in bone quality that defines osteoporosis
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Papers (43)：
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Kiyotaka Arai, Fumiyo Saito, Masashi Miyazaki, Haruto Kushige, Yayoi Izu, Noritaka Maeta, Kazuaki Yamazoe. Small Molecules Temporarily Induce Neuronal Features in Adult Canine Dermal Fibroblasts. International Journal of Molecular Sciences. 2023. 24. 21. 15804-15804
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Mengjie Zhu, Fabian Metzen, Mark Hopkinson, Janina Betz, Juliane Heilig, Jassi Sodhi, Thomas Imhof, Anja Niehoff, David E. Birk, Yayoi Izu, et al. Ablation of collagen XII disturbs joint extracellular matrix organization and causes patellar subluxation. iScience. 2023. 26. 7. 107225-107225
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Megumi Furuhata-Yoshimura, Tomomi Yamaguchi, Yayoi Izu, Tomoki Kosho. Homozygous splice site variant affecting the first von Willebrand factor A domain of COL12A1 in a patient with myopathic Ehlers-Danlos syndrome. American Journal of Medical Genetics Part A. 2023. 191. 10. 2631-2639
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Yayoi Izu, David E. Birk. Collagen XII mediated cellular and extracellular mechanisms in development, regeneration, and disease. Frontiers in Cell and Developmental Biology. 2023. 11
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Shuhei Kajikawa, Yoichi Ezura, Yayoi Izu, Kazuhisa Nakashima, Masaki Noda, Akira Nifuji. Profilin-1 negatively controls osteoclast migration by suppressing the protrusive structures based on branched actin filaments. Journal of Bone and Mineral Metabolism. 2022. 40. 4. 561-570
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MISC (8)：
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R. Hanyu, Y. Saita, J. Nagata, Y. Izu, H. Hemmi, S. Takade, Y. Ezura, H. Kurosawa, M. Noda. Aging Dependent and Independent Effects of b2 Adrenergic Receptor Signaling on Bone Formation Induced by Intermittent PTH Treatment Female Mice. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S204-S204
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T. Nakamoto, F. Mizoguchi, Y. Izu, T. Hayata, Y. Ezura, D. Mathis, C. Benoist, N. Miyasaka, M. Noda. Deficiency of the Nucleocytoplasmic Shuttling Protein CIZ Suppresses K/BxN Serum-Induced Model of Rheumatoid Arthritis. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S487-S487
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M. Nagao, Y. Saita, J. Nagata, Y. Izu, T. Hayata, H. Hemmi, Y. Ezura, H. Kurosawa, M. Noda. Role of OPN in Beta-adrenergic Signaling Induced Bone Loss in vivo. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S416-S416
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K. Miyai, Y. Izu, H. Hemmi, T. Hayata, T. Nakamoto, Y. Ezura, T. Pawson, S. Mizutani, M. Noda. Deficiency of NCK1, an Actin Cytoskeletal Modulator with SH2/SH3 Motifs, Induces Bone Loss via Suppression of Bone Formation and Induction of Biochemical High Bone Turnover State. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S380-S380
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R. Hanyu, Y. Saita, J. Nagata, Y. Izu, T. Hayata, H. Hemmi, S. Takeda, Y. Ezura, K. Nakashima, H. Kurosawa, et al. beta 2 adrenergic receptor deficiency enhances bone mass in by antagonizing against aging-induced bone loss and blunts anabolic effects of PTH on osteoblasts. JOURNAL OF BONE AND MINERAL RESEARCH. 2007. 22. S88-S88
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Education (2)：
- 2002 - 2006 日本獣医畜産大学(現 日本獣医生命科学大学) 獣医学研究科博士課程 獣医学専攻
- 1996 - 2002 日本獣医畜産大学(現 日本獣医生命科学大学) 獣医学部 獣医学科
Work history (8)：
- 2024/04 - 現在 Nippon Veterinary and Life Science University Faculty of Veterinary Science School of Veterinary Medicine Professor
- 2018/04 - 2024/03 Okayama University of Science Department of Veterinary Medicine Associate Professor
- 2016 - 2018 Chiba Institute of Science Faculty of Risk and Crisis Management, Department of Risk and Crisis Management for Animals Lecturer
- 2014 - 2016 Tokyo Medical and Dental University Medical Research Institute Assistant professor
- 2013 - 2014 University of South Florida College of Medicine Research Associate
- 2010 - 2013 Pennstate University college of Medicine postdoctoral fellow
- 2008 - 2010 University of South Floria College of Medicine Postdoctoral fellow
- 2006/04 - 2008/07 Tokyo medical and dental university Medical Research Institute
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Awards (11)：
- 2022/11 - 第2回JEFA賞 基礎部門・最優秀賞 ミオパチー型EDSの筋病態メカニズムの解明
- 2022 - 内藤記念科学振興財団 科学奨励賞 脂肪エネルギー代謝が制御する筋力増加メカニズムの解明
- 2021 - 日本骨代謝学会 日本骨代謝学会フロンティア研究者助成 FACITタイプ12型コラーゲンによる運動器制御機構の解明
- 2021 - 森永奉仕会 森永賞 小児希少疾患であるミオパチー型エーラス・ダンロス症候群のエネルギー代謝機構をターゲットとした治療法の開発
- 2018 - 鈴木謙三記念医科学応用研究財団 生活習慣病における医学、薬学の萌芽的研究 サルコペニアの病態マーカーの同定
- 2017 - 内藤記念科学振興財団 内藤記念科学奨励賞受賞 ロコモティブシンドロームにおける筋肉・腱・骨ネットワークの制御
- 2016 - 34th the Japanese Society for Bone and Mineral Research poster award Collagen XII is associated with cell-cell communication in tendon.
- 2015 - 東京医科歯科大学 学長裁量優秀若手研究者奨励賞 骨芽細胞の終末分化における細胞競合メカニズムの解明
- 2015 - 金原一郎記念医学医療振興財団 基礎医学研究賞 筋骨格系組織のおけるメカノセンシング機構の解明
- 2015 - 中冨健康科学振興財団 研究助成奨励賞 ウルリッヒ病発症に起因するVI型およびXII型コラーゲンの筋骨格系における相互的な制御機構の解明
- 2015 - 武田科学振興財団 医学系研究奨励(基礎)賞 骨粗鬆症病態を規定する骨質の非線維性コラーゲンによる制御
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