Rchr
J-GLOBAL ID：202001015950455253
Update date: Jan. 16, 2025
Matsunaga Naoya
マツナガ ナオヤ | Matsunaga Naoya
Affiliation and department：
Research keywords (3)：
クライオ電子顕微鏡
, 慢性炎症性疾患の病態解析
, DDS,LNP
Research theme for competitive and other funds (16)：
- 2022 - 2026 慢性腎臓病時の学習記憶リズム障害機構を起点とした認知症の統合研究
- 2022 - 2025 細胞伝達時計の機能解析と創薬育薬を指向した基礎的研究
- 2020 - 2023 ROCK inhibitor for treating intraocular fibrosis by modulating epithelial-to-mesenchymal transition.
- 2020 - 2022 Development of the regulation of tumor macrophages dynamics using microcurrent stimulation
- 2018 - 2021 Development of health promotion method using microcurrent stimulation to activate the body clock
- 2016 - 2019 Clarification of the mechanism underlying inflammation-based pathology from viewpoints of chrono-chemical biology
- 2015 - 2018 The underlying mechanism of glucocorticoid-regulated diurnal exacerbation of neuropathic pain hypersensitivity and its evaluation as a target of anti-allodynic drug
- 2015 - 2018 Regulation of dynamics in breast cancer stem cells based on molecular clock.
- 2013 - 2016 Role of molecular clock on the homeostatic communication between each organ in chronic kidney disease
- 2012 - 2015 Exploration of analgesic target for tumor-induced neuropathic pain based on the molecular mechanism of circadian rhythm in allodynia
- 2012 - 2015 Elucidation of the communication rhythm alteration mechanism between organizations at the time of the chronic hepatitis and development of the new anticancer medicine
- 2011 - 2014 分子時計を基盤とした、癌組織-転移組織間コミュニケーションの分子機構解明と新規の時間薬剤への応用
- 2010 - 2011 Development of a new hypoxia targeting chrono-gene therapy in cancer.
- 2009 - 2011 Discovery and development of antitumor drugs focused on the molecular clock of dedifferentiation and apoptosis during carcinogenesis
- 2009 - 2010 Protection afforded by a selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, against drug-induced liver injury.
- 2008 - 2009 Molecular basis for the dosing-time dependent change in the intratumoral delivery of oxaliplatin by transferrin-targeting liposomes
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Papers (125)：
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Yuya Yoshida, Tomohito Tanihara, Keika Hamasaki, Fumiaki Tsurusaki, Taiki Fukuda, Satoka Adachi, Yuma Terada, Kaita Otsuki, Naoki Nishikawa, Kohei Fukuoka, et al. Targeting macrophage circadian rhythms with microcurrent stimulation to activate cancer immunity through phagocytic defense. Theranostics. 2025. 15. 2. 340-361
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Yuya Yoshida, Naoki Nishikawa, Kohei Fukuoka, Akito Tsuruta, Kaita Otsuki, Taiki Fukuda, Yuma Terada, Tomohito Tanihara, Taisei Kumamoto, Ryotaro Tsukamoto, et al. Monocyte/Macrophage-Specific Loss of ARNTL Suppresses Chronic Kidney Disease-Associated Cardiac Impairment. International Journal of Molecular Sciences. 2024. 25. 23. 13009-13009
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Yumi Okano, Tomoaki Yamauchi, Runa Fukuzaki, Akito Tsuruta, Yuya Yoshida, Yuya Tsurudome, Kentaro Ushijima, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo. Oncogenic accumulation of cysteine promotes cancer cell proliferation by regulating the translation of D-type cyclins. The Journal of biological chemistry. 2024. 107890-107890
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Tomoaki Yamauchi, Yumi Okano, Daishu Terada, Sai Yasukochi, Akito Tsuruta, Yuya Tsurudome, Kentaro Ushijima, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo. Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT. Cancer & Metabolism. 2024. 12. 1
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Junhao Li, Kengo Hamamura, Yuya Yoshida, Shimpei Kawano, Shohei Uchinomiya, Jiahongyi Xie, Damiana Scuteri, Kohei Fukuoka, Orion Zaitsu, Fumiaki Tsurusaki, et al. Hericenone C attenuates the second phase of formalin-induced nociceptive behavior by suppressing the accumulation of CD11c-positive cells in the paw epidermis via phosphorylated P65. Biochemical and Biophysical Research Communications. 2024. 720. 150077-150077
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MISC (29)：
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島添隆雄, 鶴留優也, 山川雄介, 吉田優哉, 窪田敏夫, 松永直哉, 川尻雄大, 小林大介. Cholecystokinin receptor type A regulates circadian physiology in mouse retina. 時間生物学. 2024. 30. 2
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山川稚葉, 安河内冴, 鶴留優也, 牛島健太郎, 鶴田朗人, 松永直哉, 小柳悟, 大戸茂弘. Analysis of the mechanism of suppression of the onset of neuropathic pain using dysfunctional clock gene mice. 日本薬学会年会要旨集(Web). 2024. 144th
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山川稚葉, 安河内冴, 鶴留優也, 牛島健太郎, 鶴田朗人, 松永直哉, 小柳悟, 大戸茂弘. 時計遺伝子の機能不全マウスにおける神経障害性疼痛の発症抑制メカニズムの解析. 次世代を担う若手のための創薬・医療薬理シンポジウムプログラム・要旨集. 2022. 2022
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小柳悟, 加藤泉希, 鶴留優也, 安河内冴, 松永直哉, 大戸茂弘. 白金製剤オキサリプラチン誘発の骨髄抑制に及ぼす薬物排泄トランスポーターMRP4の概日リズムの影響. Fundamental Toxicological Sciences (Web). 2021. 8. Supplement
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山川稚葉, 安河内冴, 鶴留優也, 牛島健太郎, 鶴田朗人, 松永直哉, 小柳悟, 大戸茂弘. 神経障害性疼痛の発症における時計遺伝子Period2の機能解析. 日本薬学会九州支部大会講演要旨集. 2021. 38th (CD-ROM)
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Books (1)：
Awards (6)：
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