Ito Kentaro

イトウケンタロウ | Ito Kentaro

Affiliation and department：
Job title： assistant professor

Research field (2)： Biophysics , Molecular biology

Research keywords (4)：微小管の集合構造形成機構 , DNA repair , RecA family recombinase , DNA strand exchange reaction

Research theme for competitive and other funds (4)：

2023 - 2026 まだら状の結合様式を示す微小管側面相互作用因子MTCL1による微小管修復機構の解析
2021 - 2023 Understanding of the mechanism of heteroduplex formation by RecA family recombinase at atomic resolution
2019 - 2021 Molecular mechanisms of DNA strand exchange reaction driven by eukaryotic RecA family recombinases
2015 - 2017 Rad51リコンビナーゼによるDNA鎖交換反応の分子機構

Papers (14)：

Kentaro Ito, Takahisa Maki, Shuji Kanamaru, Masayuki Takahashi, Hiroshi Iwasaki. The Swi5-Sfr1 complex regulates Dmc1- and Rad51-driven DNA strand exchange proceeding through two distinct three-stranded intermediates by different mechanisms. Nucleic Acids Research. 2024
Masayuki Takahashi, Kentaro Ito, Hiroshi Iwasaki, Bengt Norden. Linear dichroism reveals the perpendicular orientation of DNA bases in the RecA and Rad51 recombinase filaments: A possible mechanism for the strand exchange reaction. Chirality. 2024. 36. 4. e23664
Axelle Renodon-Corniere, Tsutomu Mikawa, Naoyuki Kuwabara, Kentaro Ito, Dmitri Levitsky, Hiroshi Iwasaki, Masayuki Takahashi. Human Rad51 Protein Requires Higher Concentrations of Calcium Ions for D-Loop Formation than for Oligonucleotide Strand Exchange. International Journal of Molecular Sciences. 2024
Jakub Muraszko, Karol Kramarz, Bilge Argunhan, Kentaro Ito, Gabriela Baranowska, Yumiko Kurokawa, Yasuto Murayama, Hideo Tsubouchi, Sarah Lambert, Hiroshi Iwasaki, et al. Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast. Nucleic Acids Research. 2021. 49. 12. 6832-6848
Aleksandar Zdravković, James M. Daley, Arijit Dutta, Tatsuya Niwa, Yasuto Murayama, Shuji Kanamaru, Kentaro Ito, Takahisa Maki, Bilge Argunhan, Masayuki Takahashi, et al. A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118. 11

ｍore...

MISC (4)：

Masayuki Takahashi, Axelle Renodon-Corniere, Tsutomu Mikawa, Naoyuki Kuwabara, Kentaro Ito, Dmitri Levitsky, Hiroshi Iwasaki. Human Rad51 Protein Requires Higher Concentrations of Calcium Ions for D-loop Formation Than for Oligonucleotide Strand Exchange. preprints.org. 2024
Jakub Muraszko, Bilge Argunhan, Kentaro Ito, Gabriela Baranowska, Anna Barg-Wojas, Karol Kramarz, Yumiko Kurokawa, Hiroshi Iwasaki, Dorota Dziadkowiec. Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast. bioRxiv. 2020
Kentaro Ito, Yasuto Murayama, Yumiko Kurokawa, Shuji Kanamaru, Yuichi Kokabu, Takahisa Maki, Bilge Argunhan, Hideo Tsubouchi, Mitsunori Ikeguchi, Masayuki Takahashi, et al. Real-time tracking reveals the catalytic process of Rad51-driven DNA strand exchange. bioRxiv. 2019
Bilge Argunhan, Masayoshi Sakakura, Negar Afshar, Misato Kurihara, Kentaro Ito, Takahisa Maki, Shuji Kanamaru, Yasuto Murayama, Hideo Tsubouchi, Masayuki Takahashi, et al. Rad51 Interaction Analysis Reveals a Functional Interplay Among Recombination Auxiliary Factors. bioRxiv. 2019

Lectures and oral presentations (2)：

DNA鎖交換反応におけるRad51のDNA結合部位の機能解析
(日本生化学会第95回大会 2022)
Rad51によるDNA三本鎖中間体からヘテロ二重鎖DNA形成機構の酵素学的解析
(日本生化学会第93回大会)

Education (2)：

2011 - 2017 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Department of Life Science
2007 - 2011 Tokyo Institute of Technology School of Bioscience and Biotechnology

Professional career (1)：

Ph.D. in Life Science (Tokyo Institute of Technology)

Work history (5)：

2022/05 - 現在 Yokohama City University Graduate School of Medical Life Science Assistant Professor
2020/10 - 2022/04 Tokyo Institute of Technology Institute of Innovative Research Appointed Assistant Professor
2018/04 - 2020/09 Tokyo Institute of Technology Institute of Innovative Research Research Fellow
2017/04 - 2018/03 Tokyo Institute of Technology Department of Life Science and Technology Researcher
2015/04 - 2017/03 Japan Society for the Promotion of Science Research Fellowship for Young Scientists

Awards (3)：

2018/09 - The Dimitris N. Chorafas Foundation Chorafas Prize 2018
2016/11 - The 10th 3R international symposium Poster Award
2016/09 - The Genetic Society of Japan Best Paper Award 2016

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