Research field (1)：
Bio-, chemical, and soft-matter physics
Research theme for competitive and other funds (5)：
2023 - 2025 新しい分子モータータンパク質の創生を目指したボトムアッ プアプローチ
2021 - 2024 Functional and Structural Relationship of V-ATPase Revealed by Single-Molecule Observation
2020 - 2023 Elucidation of the rotation mechanism of V-ATPase by electrochemical potential
2022 - 2023 ボトムアップアプローチによる分子モータータンパク質の機能改変
2019 - 2021 Molecular Mechanisms of Selective Ion Transport by Common Protein Structures
Papers (9)：
Takanori Harashima, Akihiro Otomo, RYOTA IINO. Mechanism-based design of DNA-nanoparticle motor with high speed and processivity comparable to motor proteins. bioRxiv. 2024
Jun Nishida, Akihiro Otomo, Takanori Koitaya, Akitoshi Shiotari, Taketoshi Minato, Ryota Iino, Takashi Kumagai. Sub-Tip-Radius Near-Field Interactions in Nano-FTIR Vibrational Spectroscopy on Single Proteins. Nano Letters. 2024
Akihiro Otomo, Misao Mizuno, Keiichi Inoue, Hideki Kandori, Yasuhisa Mizutani. Protein dynamics of a light-driven Na+ pump rhodopsin probed using a tryptophan residue near the retinal chromophore. Biophysics and Physicobiology. 2023
Akihiro Otomo, Tatsuya Iida, Yasuko Okuni, Hiroshi Ueno, Takeshi Murata, Ryota Iino. Direct observation of stepping rotation of V-ATPase reveals rigid component in coupling between Vo and V1 motors. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 42. e2210204119
Akihiro Otomo, Takahiro Kosugi. Tackle “Molecular Engine” by early-career researchers. Biophysics and Physicobiology. 2022. 19. e190039
Jun Nishida, Akihiro Otomo, Ryota Iino, Takashi Kumagai. Sub-tip-radius near-field interactions in nano-FTIR vibrational spectroscopy on single protein particles. Enhanced Spectroscopies and Nanoimaging 2023. 2023
A. Otomo, H. Ishikawa, M. Mizuno, Y. Mizutani, S. Aono. Structural changes in the heme and heme pocket upon CO dissociation of CooA observed by time-resolved resonance Raman spectroscopy. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2014. 19. S287-S287
Lectures and oral presentations (32)：
Sodium motive force-driven ATP synthesis by EhV-ATPase
(21st International Union for Pure and Applied Biophysics and 62nd Biophysics Society of Japan 2024)
Molecular Studies on Rotary V-ATPase
(日本生物物理学会北海道支部講演会 2024)
Conversion of ion selectivity of rotary V-ATPase
(2024)
