Ihara Daisuke

イハラダイスケ | Ihara Daisuke

Affiliation and department：
Job title：助教

Research field (3)： Neuroscience - general , Molecular biology , Pharmaceuticals - health and biochemistry

Research keywords (5)：培養神経細胞 , 転写因子 , BDNF , Myocardin-related transcription factor (MRTF) , serum response factor(SRF)

Research theme for competitive and other funds (6)：

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Papers (18)：

Daisuke Ihara, Miho Mizukoshi, Akiko Tabuchi. Brain-derived neurotrophic factor (BDNF) downregulates mRNA levels of suppressor of cancer cell invasion (SCAI) variants in cortical neurons. Genes to Cells. 2024. 29. 1. 99-105
Takashi Shibata, Daisuke Ihara, Yuji Kirihara, Tohru Yagi, Akiko Tabuchi, Satoshi Kuroda. Enhancing c-fos mRNA Expression in Primary Cortical Cell Cultures with a Dynamic Magnetic Fields Device. IEEJ Transactions on Electrical and Electronic Engineering. 2023. 18. 1. 1932-1938
Daisuke Ihara, Hiroki Tanabe, Ichiro Takasaki, Akiko Tabuchi. Endogenous SOLOIST/MRTFB i4, a Neuronal Isoform of MKL2/MRTFB, Positively and Negatively Regulates SRF Target Immediate Early Genes in Neuro-2a Cells. Biological and Pharmaceutical Bulletin. 2023. 46. 8. 1141-1144
Hironori Nakayama, Daisuke Ihara, Mamoru Fukuchi, Kazufumi Toume, Chisato Yuri, Masaaki Tsuda, Naotoshi Shibahara, Akiko Tabuchi. The extract based on the Kampo formula daikenchuto (Da Jian Zhong Tang) induces Bdnf expression and has neurotrophic effects in cultured cortical neurons. Journal of Natural Medicines. 2023. 77. 3. 584-595
Daisuke Ihara, Tomoaki Miyata, Mamoru Fukuchi, Masaaki Tsuda, Akiko Tabuchi. SRF and SRF cofactor mRNA expression is differentially regulated by BDNF stimulation in cortical neurons. Biological and Pharmaceutical Bulletin. 2023. 46. 4. 636-639

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Lectures and oral presentations (28)：

転写コアクチベーターMRTFBの神経活動およびRho経路依存的な核移行とSRF標的遺伝子の発現制御機構に関する解析
(日本生化学会北陸支部第42回大会 2024)
転写活性化因子MRTFBのカルシニューリン経路依存的な核移行およびSRF標的遺伝子発現制御系に関する解析
(日本薬学会北陸支部第135回例会 2023)
Ca2+ signaling-dependent gene expression mediated by nuclear translocation of SRF coactivator MRTFB from postsynapses
(2023)
転写活性化因子MRTFBのin vitroおよびin vivoにおける神経活動依存的な核移行と遺伝子発現制御機構に関する解析
(日本生化学会北陸支部第41回大会 2023)
転写活性化因子MRTFBは細胞内Ca2+シグナリング依存的に核移行しSRF標的遺伝子の発現を制御する
(日本薬学会北陸支部第134回例会 2022)

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Education (3)：

2010 - 2013 University of Toyama Graduate School of Innovative Life Science
2008 - 2010 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Education
2004 - 2008 University of Toyama Faculty of Pharmacy and Pharmaceutical Sciences

Work history (3)：

2019/10 - 現在 University of Toyama
2017/05 - 2019/09 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research
2013/04 - 2017/05 東北大学病院薬剤部

Association Membership(s) (3)：

日本生化学会 , 日本薬学会 , 日本神経化学会

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