Hirose Tomoyasu

ヒロセトモヤス | Hirose Tomoyasu

Affiliation and department：
Research theme for competitive and other funds (8)：

2022 - 2025 ライブラリー指向型イベルメクチン全合成法の確立と誘導体創製研究
2020 - 2023 発酵工学を利用した抗嫌気性菌活性物質ルミナミシンの非天然型誘導体の創製
2018 - 2021 Total synthesis of 10-14 membered ring fused dimacrolides, potent narrow antimicrobial activities
2015 - 2018 Toward the total synthesis of novel anti-protozoal 12-membered macrolides
2014 - 2017 Screening of Plasmodium falciparum enoyl-Acyl carrier protein reductase (PfFabI) inhibitors from microbial metabolites for prophylaxis and blocking transmission of malaria

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Papers (74)：

Koji Takemoto, Ryo Nakayama, Koichi Fujimoto, Yumiko Suzuki, Yukiko Takarabe, Masako Honsho, Sachiko Kitahara, Yoshihiko Noguchi, Hidehito Matsui, Tomoyasu Hirose, et al. In vitro and in vivo activities of KSP-1007, a broad-spectrum inhibitor of serine- and metallo-β-lactamases, in combination with meropenem against carbapenem-resistant Gram-negative bacteria. Antimicrobial Agents and Chemotherapy. 2024
So-Ichiro Kimura, Yoshihiro Watanabe, Yudai Mikasa, Rei Miyano, Toshiyuki Tokiwa, Kenichi Nonaka, Takuji Nakashima, Yoshihiko Noguchi, Tomoyasu Hirose, Toshiaki Sunazuka, et al. Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058. The Journal of antibiotics. 2024
Haruki Azami, Yoshihiro Watanabe, Kazunari Sakai, Hiroki Nakahara, Hiroki Kojima, Toshiyuki Tokiwa, Kenichi Nonaka, Yoshihiko Noguchi, Yuriko Nagano, Tomoyasu Hirose, et al. Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499. The Journal of antibiotics. 2024
Arisu Tahara, Kazuki Tani, Miyu Wakatsuki, Toshiyuki Tokiwa, Mayuka Higo, Kenichi Nonaka, Tomoyasu Hirose, Rei Hokari, Aki Ishiyama, Masato Iwatsuki, et al. A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921. The Journal of Antibiotics. 2023
Sho Inoue, Yuki Inahashi, Makoto Itakura, Gen Inoue, Kyoko Muneshige, Tomoyasu Hirose, Masato Iwatsuki, Masashi Takaso, Masayuki Miyagi, Kentaro Uchida. Medermycin Inhibits TNFα-Promoted Inflammatory Reaction in Human Synovial Fibroblasts. International journal of molecular sciences. 2023. 24. 18

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MISC (6)：

渡邊善洋, 渡邊善洋, 荒川絵美, 近藤直純, 野中健一, 野中健一, 池田朱里, 池田朱里, 廣瀬友靖, 廣瀬友靖, et al. Search for antimalarial compounds from microbial secondary metabolites. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
松尾洋孝, 宮野怜, 野口吉彦, 武晃, 中西淳, 重村克己, 廣瀬友靖, 砂塚敏明, 高橋洋子, 大村智, et al. "Streptomyces rosa subsp.notoensis"OS-3966株が生産する新規nanaomycin類縁体に関する研究. 日本放線菌学会大会講演要旨集. 2018. 33回. 133-133
Tsuyoshi Yamamoto, Naoyuki Izumi, Hideaki Ui, Akito Sueki, Rokuro Masuma, Kenichi Nonaka, Tomoyasu Hirose, Toshiaki Sunazuka, Takayuki Nagai, Haruki Yamada, et al. Wickerols A and B: novel anti-influenza virus diterpenes produced by Trichoderma atroviride FKI-3849. TETRAHEDRON. 2012. 68. 45. 9267-9271
Toshiaki Sunazuka, Yoshihiko Noguchi, Tomoyasu Hirose, Yujiro Furuya, Tatsuhiko Tsuchiya, Aki Ishiyama, Kazuhiko Otoguro, Satoshi Omura. Total synthesis and determination of absolute stereochemistry of apparicines, novel antimalarial indole alkaloids. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2011. 242
Izumi Naoyuki, Yamada Haruki, Shiomi Kazuro, Omura Satoshi, Yamamoto Tsuyoshi, Ui Hideaki, Sueki Akito, Masuma Rokuro, Nonaka Kenichi, Hirose Tomoyasu, et al. P-41 Novel Anti-FLU Antibiotics, Wickerols, Produced by Trichoderma sp.(Poster Presentation). Symposium on the Chemistry of Natural Products, symposium papers. 2008. 50. 0. 385-390

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