Rchr
J-GLOBAL ID：202001017664520008
Update date: Feb. 01, 2024
OOKI Takuya
オオキ タクヤ | OOKI Takuya
Affiliation and department：
Research field (1)：
Tumor biology
Research keywords (5)：
Hippo-YAP1シグナル
, 細胞外基質(ヒアルロン酸)によるシグナル制御
, 乳がん、卵巣がん、BRCAness
, びまん型胃がん、ヘリコバクターピロリ菌
, 合成致死誘導療法
Research theme for competitive and other funds (2)：
- 2021 - 2026 Hippo-YAP経路を利用したBRCAness陽性がんの新規合成致死療法開発
- 2023 - 2025 PAR1bを標的とした人為的BRCAness誘導によるがん種横断的な合成致死療法開発の研究
Papers (5)：
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Atsushi Takahashi-Kanemitsu, Mengxue Lu, Christopher Takaya Knight, Takayoshi Yamamoto, Takuo Hayashi, Yusuke Mii, Takuya Ooki, Ippei Kikuchi, Akira Kikuchi, Nick Barker, et al. The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells. Science signaling. 2023. 16. 794. eabp9020
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Takuya Ooki, Masanori Hatakeyama. Protocol for visualizing conditional interaction between transmembrane and cytoplasmic proteins. STAR Protocols. 2021. 2. 2. 100430-100430
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Satoshi Imai, Takuya Ooki, Naoko Murata-Kamiya, Daisuke Komura, Kamrunnesa Tahmina, Weida Wu, Atsushi Takahashi-Kanemitsu, Christopher Takaya Knight, Akiko Kunita, Nobumi Suzuki, et al. Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis. Cell Host & Microbe. 2021. 29. 6. 941-958
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Takuya Ooki, Masanori Hatakeyama. Hyaluronan Degradation Promotes Cancer via Hippo-YAP Signaling: An Intervention Point for Cancer Therapy. BioEssays. 2020. 42. 7. 2000005-2000005
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Takuya Ooki, Naoko Murata-Kamiya, Atsushi Takahashi-Kanemitsu, Weida Wu, Masanori Hatakeyama. High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b. Developmental Cell. 2019. 49. 4. 590-604.e9
Lectures and oral presentations (8)：
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Helicobacter pylori CagA induces reversible BRCAness through PAR1b inhibition.
(2020)
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「ヒアルロン酸が有するジキルとハイド的側面 -ヒアルロン酸によるがん抑制性Hippoシグナルの制御機構およびがん細胞におけるその破綻-」
(東京大学大学院医学系研究科 病因・病理学専攻 若手講演会 2019)
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Activation of the tumor suppressive Hippo pathway by high-molecular-weight hyaluronan and its breakdown in breast cancer.
(2019)
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Activation of the tumor suppressive Hippo pathway by high-molecular-weight hyaluronan and its breakdown in breast cancer.
(2018)
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Activation of the tumor suppressive Hippo pathway by high-molecular-weight hyaluronan and its perturbation in breast cancer.
(Sapporo international cancer symposium SCS 2018)
ｍore...
Education (2)：
- 2014 - 2018 The University of Tokyo
- 2008 - 2014 Musashino University Department of Pharmaceutical Sciences
Work history (2)：
- 2022/04 - 現在 Microbial Chemistry Research Foundation
- 2018/04 - 2022/03 東京大学 大学院 医学系研究科 微生物学分野 特任研究員
Association Membership(s) (2)：
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