Rchr
J-GLOBAL ID：202001017905477583
Update date: Feb. 01, 2024
Hayashi Tomohiko
ハヤシ トモヒコ | Hayashi Tomohiko
Affiliation and department：
Job title：
Assistant Professor
Other affiliations (1)：
Research field (1)：
Bio-, chemical, and soft-matter physics
Research keywords (5)：
Morphometric approach
, Integral equation theory
, Solution theory
, Computational science
, Biophysics
Research theme for competitive and other funds (3)：
- 2022 - 2025 次世代ペプチド薬の物理理論に基づく高速デザイン法の開発
- 2019 - 2022 Development of a physics-based fast screening method for detecting the cancer-therapeutic peptides
- 2019 - MDM2をターゲットとした新規抗癌剤候補ペプチドの設計・合成
Papers (38)：
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Ken-ichi Amano, Satoshi Furukawa, Yuto Kubo, Yuka Nakamura, Rina Ishii, Ayane Tanase, Masahiro Maebayashi, Tomohiko Hayashi, Naoya Nishi, Tetsuo Sakka. Nonadditivities of the Particle Sizes Hidden in Model Pair Potentials and Their Effects on Physical Adsorptions. Langmuir. 2023. 39. 37. 12999-13007
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Satoshi Yasuda, Tomohiko Hayashi, Takeshi Murata, Masahiro Kinoshita. Physical pictures of rotation mechanisms of F1- and V1-ATPases: Leading roles of translational, configurational entropy of water. Frontiers in Molecular Biosciences. 2023. 10
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Kazuma AOKI, Tomohiko HAYASHI, Satoshi WATANABE, Toyohiko HAYASHI, Yoshio KOGA, Go OMORI, Koichi KOBAYASHI, Makoto SAKAMOTO. Three-dimensional morphological evaluation of the lateral femoral condyle of young children with discoid meniscus. 2022. 43. 97-105
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Taisei Yamamoto, Satoshi Yasuda, Rinshi S. Kasai, Ryosuke Nakano, Simon Hikiri, Kanna Sugaya, Tomohiko Hayashi, Satoshi Ogasawara, Mitsunori Shiroishi, Takahiro K. Fujiwara, et al. A methodology for creating mutants of G-protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering. Protein Science. 2022. 31. 10
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Kanna Sugaya, Satoshi Yasuda, Shingo Sato, Chen Sisi, Taisei Yamamoto, Daisuke Umeno, Tomoaki Matsuura, Tomohiko Hayashi, Satoshi Ogasawara, Masahiro Kinoshita, et al. A methodology for creating thermostabilized mutants of G-protein coupled receptors by combining statistical thermodynamics and evolutionary molecular engineering. Protein Science. 2022. 31. 9
ｍore...
MISC (3)：
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Masahiro Kinoshita, Tomohiko Hayashi. Accurate and rapid calculation of hydration free energy and its physical implication for biomolecular functions. Biophysical Reviews. 2020. 12. 469-480
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Takeshi Murata, Satoshi Yasuda, Tomohiko Hayashi, Masahiro Kinoshita. Theoretical identification of thermostabilizing amino acid mutations for G-protein-coupled receptors. Biophysical Reviews. 2020. 12. 323-332
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安田賢司, 林智彦, 村田武士, 木下正弘. サーモフィリックロドプシンの極めて高い熱安定性に関する統計熱力学的解析. 月刊「細胞」. 2020. 52. 2. 37-41
Books (1)：
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Statistical Thermodynamics on the Binding of Biomolecules, Part II: Basis of Protein-Ligand and Protein-Protein Interactions, Chapter 13, The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery
Springer 2018
Education (2)：
- - 2012 Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering
- - 2005 Tokyo Institute of Technology Faculty of Life Science and Engineering
Professional career (1)：
Work history (6)：
Awards (1)：
- 2015 - 日本生物物理学会 第4回 Biophysics and Physicobiology 論文賞 Full-Quantum chemical calculation of the absorption maximum of bacteriorhodopsin: a comprehensive analysis of the amino acid residues contributing to the opsin shift
Association Membership(s) (4)：
日本臨床バイオメカニクス学会
, 日本化学会
, 米国生物物理学会(Biophysical Society, U.S.A.)
, 日本生物物理学会
