2019 - 2022 Interaction between genetic COMT deficiency and Mg defects induced diseases: mechanisms and therapeutic strategy
Papers (10):
Emi Kawakita, Fan Yang, Sen Shi, Yuta Takagaki, Daisuke Koya, Keizo Kanasaki. Inhibition of Dipeptidyl Peptidase-4 Activates Autophagy to Promote Survival of Breast Cancer Cells via the mTOR/HIF-1α Pathway. Cancers. 2023. 15. 18
Juthi Adhikari, Taro Hirai, Emi Kawakita, Kunimitsu Iwai, Daisuke Koya, Keizo Kanasaki. Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis. Journal of diabetes investigation. 2023. 14. 7. 844-855
Emi Kawakita, Daisuke Koya, Keizo Kanasaki. CD26/DPP-4: Type 2 Diabetes Drug Target with Potential Influence on Cancer Biology. Cancers. 2021. 13. 9. 2191-2191
Emi Kawakita, Fan Yang, Asako Kumagai, Yuta Takagaki, Munehiro Kitada, Yasuo Yoshitomi, Takayuki Ikeda, Yuka Nakamura, Yasuhito Ishigaki, Keizo Kanasaki, et al. Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling. Molecular Cancer Research. 2021. 19. 1. 61-73
Yang Fan, 高垣 雄太, 吉冨 泰央, 池田 崇之, Li Jinpeng, 北田 宗弘, 熊谷 麻子, 川北 恵美, Shi Sen, 金崎 啓造, et al. Dipeptidyl peptidase-4の阻害は、CXCL12/CXCR4/mTOR軸を介して上皮間葉転換および乳癌転移を促進する(Inhibition of dipeptidyl peptidase-4 accelerates epithelial-mesenchymal transition and breast cancer metastasis via the CXCL12/CXCR4/mTOR axis). 金沢医科大学雑誌. 2019. 44. 2. 68-68
川北 恵美, 熊谷 麻子, 金崎 啓造. メトホルミンはmTOR経路の抑制を介してDPP-4阻害により誘導される乳癌細胞のEMTおよび肺転移を抑制する可能性がある(Metformin suppressed DPP-4 inhibitor-induced breast cancer EMT and lung metastasis via suppression of mTOR signaling). 日本癌学会総会記事. 2019. 78回. E-2105