Research keywords (3):
human cell-like liposome
, chaprone
, cell free protein synthesis
Research theme for competitive and other funds (6):
2023 - 2025 ポリアミンがCAGリピート由来の非標準翻訳に与える影響と翻訳開始点の解明
2021 - 2025 変異型アクチンの試験管内バイオジェネシスとその分子機構の解析
2021 - 2023 非典型翻訳の試験管内再構成とそのメカニズムの解明
2017 - 2021 In vitro translation and analysis of neurodegenerative diseases
2016 - 2019 Development of palm-sized ion gun and test of cell adhesion-activation for medical applications
2014 - 2017 Functional network of nascent protein and molecular chaperones
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Papers (29):
Kodai Machida, Rin Tanaka, Seraya Miki, Shotaro Noseda, Mayumi Yuasa-Sunagawa, Hiroaki Imataka. High-throughput screening for a SARS-CoV-2 frameshifting inhibitor using a cell-free protein synthesis system. BioTechniques. 2024. 76. 4. 161-168
Kodai Machida, Shoma Miyawaki, Kuru Kanzawa, Taiki Hakushi, Tomonori Nakai, Hiroaki Imataka. An in Vitro Reconstitution System Defines the Defective Step in the Biogenesis of Mutated β-Actin Proteins. ACS synthetic biology. 2021. 10. 11. 3158-3166
Chihiro Hirayama, Kodai Machida, Kentaro Noi, Tadayoshi Murakawa, Masaki Okumura, Teru Ogura, Hiroaki Imataka, Kenji Inaba. Distinct roles and actions of protein disulfide isomerase family enzymes in catalysis of nascent-chain disulfide bond formation. iScience. 2021. 24. 4. 102296-102296