Ishii Nozomi

イシイノゾミ | Ishii Nozomi

Affiliation and department：
Job title：助教

Research field (1)： Bioorganic chemistry

Research keywords (2)： Glycobiology , Glycochemistry

Research theme for competitive and other funds (4)：

2023 - 2026 糖脂質SQAPによる固形腫瘍組織内酸素分圧上昇機序の解明と放射線治療への展開
2023 - 2026 抗体糖鎖特異的エンド-β-N-アセチルグルコサミニダーゼの活性検出プローブの開発
2022 - 2024 Protecting group free glycosylation of phosphatidic acid in aqueous media
2016 - 2017 細胞内ヒトエンド-β-N-アセチルグルコサミニダーゼ活性検出系の確立と酵素阻害剤の探索

Papers (23)：

Tadashi Satoh, Maho Yagi-Utsumi, Nozomi Ishii, Tsunehiro Mizushima, Hirokazu Yagi, Ryuichi Kato, Yuriko Tachida, Hiroaki Tateno, Ichiro Matsuo, Koichi Kato, et al. Structural basis of sugar recognition by SCFFBS2 ubiquitin ligase involved in NGLY1 deficiency. FEBS letters. 2024
Yukiko Yoshida, Tsuyoshi Takahashi, Nozomi Ishii, Ichiro Matsuo, Satoshi Takahashi, Haruka Inoue, Akinori Endo, Hikaru Tsuchiya, Meari Okada, Chikara Ando, et al. Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation. Molecular Cell. 2024. 84. 16. 3115-3127.e11
Nozomi Ishii, Shusei Inoue, Kanae Sano, Satoshi Takahashi, Ichiro Matsuo. Synthesis of a fluorescent probe for measuring the activity of endo-β-N-acetylglucosaminidases recognizing hybrid-type N-glycans. Bioorganic & Medicinal Chemistry. 2024. 100. 117612
Hiroshi Muto, Nozomi Ishii, Mitsuhiro Iwamoto, Ichiro Matsuo. Rapid preparation of a glycan oxazoline and a homogeneously glycosylated antibody with an enzyme-immobilized monolithic column. Carbohydrate Research. 2024. 536. 109024-109024
Hiroaki Horiuchi, Kota Nishikawa, Nozomi Ishii, Koki Kano, Shunsuke Shinada, Nene Osawa, Aoi Horikoshi, Toshitada Yoshihara, Fumio Sugawara, Kengo Sakaguchi, et al. A silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-α-d-glucopyranose functions as an efficient photosensitizer for photodynamic therapy. Photodiagnosis and Photodynamic Therapy. 2024. 45. 103898-103898

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MISC (4)：

佐野加苗, 菊間隆志, 高橋諭, 石井希実, 松尾一郎, 武田陽一. Synthesis of UDP-GlcNAc probe to modify N-glycan on artificial liposomes for development of a dolichol-linked oligosaccharides tracking system. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
佐野加苗, 菊間隆志, 高橋諭, 石井希実, 松尾一郎, 武田陽一. Synthesis of DPAGT1, substrate for N-glycan modification on liposome surfaces to analyze flipping mechanism of N-glycans. 日本糖質学会年会要旨集. 2021. 40th
Nozomi Ishii, Shogo Iwamoto, Jyunichi Kumada, Yuji Matsuzaki, Ichiro Matsuo. Analysis of substrate specificity for endo-M and its mutants using synthetic glycans. GLYCOBIOLOGY. 2014. 24. 11. 1118-1118
Shinpei Miyazawa, Nozomi Ishii, Takashi Utsui, Masaki Hamada, Ichiro Matsuo. Convergent synthesis of biantennary complex type nonasaccharide containing LacdiNAc structure based on the regioselective glycosylation and inversion reactions. GLYCOBIOLOGY. 2014. 24. 11. 1112-1113

Patents (5)：

抗体上糖鎖に作用するENGaseの探索プローブ
糖リン脂質の製造方法
糖化合物、糖化合物の製造方法、ENGase活性検出用組成物、新規ENGaseのスクリーニング方法、及びENGase活性阻害剤のスクリーニング方法
糖リン脂質の製造方法、及び糖リン脂質
糖化合物、糖化合物の製造方法、ENGase活性検出用組成物、及びENGase活性阻害剤のスクリーニング方法

Books (1)：

Glycolipids, Methods in molecular biology
Humana New York 2023

Lectures and oral presentations (22)：

糖鎖分子プローブを用いた糖質関連酵素の簡便な活性検出法の開発研究
(第43回日本糖質学会年会 2024)
複合型糖鎖を用いた抗体糖鎖特異的ENGase(Endo-S)の活性検出
(日本農芸化学会2024年度大会 2024)
有機合成化学を基盤とした糖質関連酵素の活性検出系の確立
(2023年度高分子学会東北支部会員増強講演会 2023)
Synthesis of the glycopeptides for evaluating the substrate specificity of peptide:N-glycanase
(2023)
Evaluation of PNGase activities using glycopeptide carrying unnatural oligosaccharides
(2023)

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Education (3)：

2015 - 2018 Gunma University Graduate School of Science and Technology
2013 - 2015 Gunma University Graduate School of Science and Technology
2009 - 2013 Gunma University

Professional career (1)：

博士(理工学) (群馬大学)

Work history (2)：

2020/09 - 現在 Gunma University Division of Molecular Science Assistant Professor
2018/04 - 2020/08 University of Canterbury Biomolecular Interaction Centre (BIC)

Awards (8)：

2024/09 - 日本糖質学会第27回日本糖質学会奨励賞糖鎖分子プローブを用いた糖質関連酵素の簡便な活性検出法の開発研究
2023/09 - Glyco26 Local Organizing Committee Glyco26 Poster Awards Evaluating the Substrate Specificity of PNGases Using Synthetic Glycopeptides
2023/09 - 日本糖質学会第3回日本糖質学会優秀講演賞 ENGase 活性の定量的評価に向けた蛍光標識糖鎖プローブの合成
2017/07 - 日本糖質学会第19回日本糖質学会ポスター賞 5糖蛍光プローブを用いたエンド-β-N-アセチルグルコサミニダーゼの活性検出
2016/11 - 東京糖鎖研究会 GlycoTOKYO2016シンポジウムポスター賞 ENGase阻害剤探索のための糖鎖基質の開発

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Association Membership(s) (5)：

日本化学会 , Forum: Carbohydrates Coming of Age (FCCA) , The New Zealand Institute of Chemistry (NZIC) , The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA) , The Japanese Society of Carbohydrate Research (JSCR)

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