Rchr
J-GLOBAL ID：202001019696564891   Update date: Apr. 11, 2024

Takashima Shinichiro

タカシマ シンイチロウ | Takashima Shinichiro
Research keywords  (5)： Vascular remodeling ,  Cardiac differentiation ,  Acute coronary syndrome ,  Nerve growth factor receptor ,  Adipose-tissue-derived stromal cells
Research theme for competitive and other funds  (3)：
  • 2021 - 2024 Development of therapeutic application of beating cardiomyocytes derived from human adipose tissue for treating heart failure
  • 2018 - 2021 The research on regulation of vascular remodeling by CD271-positive cells
  • 2014 - 2016 Impact of clinical characteristics on the yield of therapeutic adipose-derived mesenchymal stem cells in a cardiovascular disease
Papers (54)：
  • Oto Inoue, Chiaki Goten, Daiki Hashimuko, Kosei Yamaguchi, Yusuke Takeda, Ayano Nomura, Hiroshi Ootsuji, Shinichiro Takashima, Kenji Iino, Hirofumi Takemura, et al. Single-cell transcriptomics identifies adipose tissue CD271+ progenitors for enhanced angiogenesis in limb ischemia. Cell reports. Medicine. 2023. 4. 12. 101337-101337
  • 野口 昌寛, 野村 章洋, 岡田 寛史, 吉田 昌平, 高島 伸一郎, 多田 隼人, 薄井 荘一郎, 高村 雅之. Usefulness of the LAVITA Telemonitoring System for Patients with Heart Failure(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. PJ080-5
  • Oto Inoue, Chiaki Goten, Daiki Hashimuko, Kosei Yamaguchi, Yusuke Takeda, Ayano Nomura, Hiroshi Ootsuji, Shinichiro Takashima, Kenji Iino, Hirofumi Takemura, et al. Single cell transcriptomics identifies adipose tissue CD271+ progenitors for enhanced angiogenesis in limb ischemia. bioRxiv : the preprint server for biology. 2023
  • Chiaki Goten, Soichiro Usui, Shinichiro Takashima, Oto Inoue, Kosei Yamaguchi, Daiki Hashimuko, Yusuke Takeda, Ayano Nomura, Kenji Sakata, Shuichi Kaneko, et al. Important Role of Endogenous Nerve Growth Factor Receptor in the Pathogenesis of Hypoxia-Induced Pulmonary Hypertension in Mice. Int. J. Mol. Sci. 2023. 24. 3. 1868
  • Yuuki Shimizu, Kazuhisa Kondo, Ryo Hayashida, Ken-ichiro Sasaki, Masanori Ohtsuka, Yoshihiro Fukumoto, Shinichiro Takashima, Oto Inoue, Soichiro Usui, Masayuki Takamura, et al. Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial. Angiogenesis. 2022
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MISC (23)：
  • Daiki Hashimuko, Oto Inoue, Soichiro Usui, Ayano Nomura, Kosei Yamaguchi, Yusuke Takeda, Chiaki Goten, Shinichiro Takashima, Kenji Sakata, Kenji Iino, et al. CD271 Expression Enhances Angiogenic Capacity in Human Adipose-Derived Stem Cells. CIRCULATION. 2022. 146
  • Yoshio Sakai, Shinya Fukunishi, Masayuki Takamura, Oto Inoue, Soichiro Usui, Shinichiro Takashima, Kazunori Kawaguchi, Akihiro Seki, Akira Asai, Yusuke Tsuchimoto, et al. INVESTIGATOR-INITIATED CLINICAL TRIAL OF AUTOLOGOUS ADIPOSE TISSUE-DERIVED REGENERATIVE (STEM) CELLS THERAPY FOR STEATOHEPATITIS-RELATED CIRRHOSIS. HEPATOLOGY. 2020. 72. 1020-1021
  • Yusuke Takeda, Oto Inoue, Ayano Nomura, Chiaki Goten, Shinichiro Takashima, Soichiro Usui, Kenji Sakata, Masa-Aki Kawashiri, Masayuki Takamura. Preadipocytes are Decreased by Sympathetic Nerve Activity in Heart Failure. CIRCULATION. 2019. 140
  • Kosei Yamaguchi, Oto Inoue, Yusuke Takeda, Chiaki Goten, Shinichiro Takashima, Soichiro Usui, Kenji Sakata, Masa-aki Kawashiri, Masayuki Takamura. Human CD271(+) Adipose-Derived Stem Cells Possess Angiogenic Capacity Through Mediating M2-Dominant Macrophage Polarization in Cell Therapy. CIRCULATION. 2019. 140
  • Chiaki Goten, Soichiro Usui, Oto Inoue, Shin-Ichiro Takashima, Hisayoshi Murai, Masayuki Takamura. Circulating CD271 is Associated With the Severity of Pulmonary Arterial Hypertension. CIRCULATION. 2019. 140
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Lectures and oral presentations  (15)：
  • Bone-marrow-derived nerve growth factor receptor-positive dendritic cells contribute to the suppression of arterial remodelling via apoptosis
    (ESC Congress 2023 2023)
  • Myeloid Nerve Growth Factor Receptor-positive Cells Suppress Arterial Remodeling via Self Apoptosis
    (2023)
  • 臨床医の視点から取り組む基礎研究
    (第160回東海・第145回北陸合同地方会 2022)
  • 遺伝子導入脂肪組織幹細胞による新しい心筋再生治療の開発
    (第21回日本再生医療学会総会 2022)
  • Myocyte-specific Enhancer Factor 2c Triggers Transdifferentiation of Adipose-tissue-derived Stromal Cells into Spontaneously Beating Cardiomyocyte-like Cells
    (2021)
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Education (2)：
  • - 2008 金沢大学大学院医学系研究科
  • 1994 - 2000 金沢大学医学部医学科
Professional career (1)：
  • 博士(医学) (金沢大学)
Work history (10)：
  • 2022/08 - 現在 金沢大学医薬保健研究域医学系 循環器内科学 助教
  • 2021/06 - 2022/07 Kanazawa University Cardiovascular Medicine
  • 2016/07 - 2021/05 金沢大学附属病院 救急部
  • 2015/04 - 金沢大学医薬保健学総合研究科 地域呼吸器症候学
  • 2013/07 - 金沢大学附属病院 集中治療部
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Association Membership(s) (7)：
European Society of Cardiology ,  日本再生医療学会 ,  日本心臓リハビリテーション学会 ,  日本救急医学会 ,  日本心臓病学会 ,  日本循環器学会 ,  日本内科学会
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