Rchr
J-GLOBAL ID：202001019920901165   Update date: Sep. 20, 2024

Yamashita Yasunobu

ヤマシタ ヤスノブ | Yamashita Yasunobu
Affiliation and department：
Osaka University

About Osaka University


Homepage URL  (2)： https://www.sanken.osaka-u.ac.jp/labs/cmc/about/member/yasunobu_yamashita ,  https://www.sanken.osaka-u.ac.jp/labs/cmc/en/about/member/yasunobu_yamashita
Research field  (1)： Pharmaceuticals - chemistry and drug development
Research keywords  (3)： Synthetic Organic Chemistry ,  Chemical Biology ,  Medicinal Chemistry
Research theme for competitive and other funds  (7)：
  • 2024 - 2027 Development of chimera molecules targeting epigenetic complexes
  • 2021 - 2026 深層学習を用いた新規活性予測器の開発とHDAC阻害薬探索への応用
  • 2021 - 2024 Development of innovative drug candidates by target guided synthesis
  • 2021 - 2024 深層学習を用いた新規創薬方法論の構築とその応用
  • 2021 - 2022 エピジェネティクス関連タンパク質ーlncRNA 複合体を対象としたRNA 分解誘導剤の開発
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Papers (33)：
  • Tetsuya Iida, Yukihiro Itoh, Yukari Takahashi, Yuka Miyake, Farzad Zamani, Yasunobu Yamashita, Yuri Takada, Toshiki Akiyama, Jun Ibaraki, Kyoka Okuda, et al. Identification of Proteolysis Targeting Chimeras (PROTACs) for Lysine Demethylase 5 and Their Neurite Outgrowth-Promoting Activity. Chemical and Pharmaceutical Bulletin. 2024. 72. 7. 638-647
  • Siyao Ni, Yuri Takada, Takaaki Ando, Shengwang Yu, Yasunobu Yamashita, Yukari Takahashi, Miho Sawada, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki. Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule. Bioorganic & medicinal chemistry letters. 2024. 105. 129759-129759
  • Yosuke Ota, Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita, Chenliang Hu, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki. Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells. Bioorganic & medicinal chemistry. 2024. 100. 117632-117632
  • Mitsuhiro Terao, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki. Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity. Bioorganic & Medicinal Chemistry. 2024. 98. 117579
  • Yasunobu Yamashita, Yukihiro Itoh, Yuri Takada, Takayoshi Suzuki. Epigenetic Inhibitors as Alzheimer's Disease Therapeutic Agents. Chemical & pharmaceutical bulletin. 2024. 72. 7. 630-637
ｍore...
MISC (2)：
  • 伊藤幸裕, 高田悠里, 山下泰信, 鈴木孝禎. Drug modalities for inhibition of protein-protein interactions. 実験医学. 2024. 42. 2
  • 山下泰信. μ-オピオイド受容体選択的蛍光プローブを用いた1分子イメージング. ファルマシア. 2020. 56. 955
Patents (4)：
  • キヌクリジン誘導体
  • 電子ビーム照射装置及び電子ビーム照射方法
  • 異常血管新生の治療剤または予防剤、および、その利用
  • 電子ビーム照射装置及び電子ビーム照射方法
Books (1)：
  • Dual Catalysis in Organic Synthesis
    Science of Synthesis 2019
Education (3)：
  • 2014 - 2017 Keio University Graduate School of Pharmaceutical Sciences Ph.D. course
  • 2012 - 2014 Keio University Graduate School of Pharmaceutical Sciences Master Course
  • 2008 - 2012 Keio University Faculty of Pharmacy Department of Pharmaceutical Sciences
Work history (4)：
  • 2022/04 - 現在 理化学研究所 客員研究員
  • 2020/01 - 現在 Osaka University The Institute of Scientific and Industrial Research Assistant Professor
  • 2017/08 - 2019/12 Bielefeld University Faculty of Chemistry Post-doctoral Researcher
  • 2017/04 - 2017/07 Technology Research Association for Next-Generation Natural Products Chemistry Post-doctoral Researcher
Awards (3)：
  • 2022/12 - 有機合成化学協会 味の素研究企画賞
  • 2018/05 - アレキサンダー・フォン・フンボルト財団 ポストドクトラルフェロー
  • 2015/03 - The Pharmaceutical Society of Japan Excellent Presentation Award
Association Membership(s) (6)：
CBI学会 ,  日本物理学会 ,  日本光線力学学会 ,  日本化学会 ,  有機合成化学協会 ,  日本薬学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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