Otsu Kinya

オオツキンヤ | Otsu Kinya

Affiliation and department：
Job title：特任教授

Research field (1)： Cardiology

Research keywords (1)： heart failure

Research theme for competitive and other funds (29)：

2021 - 2024 ミトコンドリア分解制御機構の解明と心不全創薬への応用
2018 - 2021 Investigation for a molecular regulatory mechanism inducing endogenous myocardial inflammation
2015 - 2018 Integrated analyses of mitochondria degradation system as a novel therapeutic target of heart failure
2009 - 2011 Role of intracellular degradation systems in genesis of heart failure
2009 - 2010 タンパク質分解系による心不全制御機構の解明

2007 - 2009 Role of selective modulation of sarcoplasmic reticulum function on cardiac contraction during ischemia.

2007 - 2008 Elucidation of molecular mechanisms underlying cell death in heart failure

2005 - 2006 Searching and validation of polymorphisms which are associated with prognosis after myocardial infarctton

2005 - 2006 Characterization of cardioprotective molecular mechanism via p38MAPK and new therapy for heart failure

2004 - 2006 Molecular mechanisms of Ca^<2+> uptake by sarcolipin in cardiac sarcoplasmic reticulum.

2004 - 2005 Elucidation of a role of ASK1 in the pathogenesis of heart failure and its application to therapeutics

2003 - 2004 Gene expression profiling in hypertrophied heart as the determinant of phenotype of heart failure

2002 - 2003 心筋及び時間息異的p38α改変マウスによる心肥大から心不全への適応破綻機序の解明

2001 - 2003 Intracellular Ca^<2+> regulation in the myocardium with ryanodine receptor type 2(+/-) heterozygous mouse

2001 - 2002 Molecular Mechanism for Excitation-contraction Coupling in Heart and its Pathophysiological Significance

2000 - 2001 Investigation of Molecular Mechanism for Excitation-contraction Coupling in Heart

2000 - 2001 Functional analysis of gap junction and its clinical application

2000 - 2000 心臓血管系におけるチャネル病の発症と成因に関する調査・研究

1999 - 2000 The role of anti-oxidant enzyme in cardioprotective effects of exercise and heat stress

1998 - 1999 Molecular Mechanisms of Cardiac Gap Junction

1998 - 1999 Prevention of atherosclerotic plaque rupture by the regulation of oxygen radical metabolism of vascular wall cells.

1998 - 1999 Treatment of heart failure by modulating Ca signaling protein gene expression

1998 - 1999 Intracellular signal transduction via acitive oxygen production in cardiac myocytes-role of redox regulation in Mn-SOD induction-

1997 - 1998 Molecular Mechanism for Calcium Signaling in Cardiomyocyte

1996 - 1997 Construction of analytical system for cardiac function of the phospholamban knock-out mouse

1995 - 1996 The molecular regulation mechanism in the cardiac calcium signaling proteins

1994 - 1995 Prevention of restenosis after PTCA by the requlation of Id, a trnscription factor of muscle differentiation.

1994 - 1994 急性心筋梗塞後の治癒過程と左室リモデリング-血中プロコラーゲンタイプIIIペプチドの意義-

1992 - 1994 Investigation for Molecular Mechanism of Regulation of Calcium Signaling Proteins in Cardiac Sarcoplasmic Reticulum and Those Biological Significance

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Papers (127)：

Ryuta Sugihara, Manabu Taneike, Tomokazu Murakawa, Takahito Tamai, Hiromichi Ueda, Rika Kitazume-Taneike, Takafumi Oka, Yasuhiro Akazawa, Hiroki Nishida, Kentaro Mine, et al. Lysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34. Nature communications. 2023. 14. 1. 4494-4494
Yasuhiro Akazawa, Manabu Taneike, Hiromichi Ueda, Rika Kitazume-Taneike, Tomokazu Murakawa, Ryuta Sugihara, Hiroki Yorifuji, Hiroki Nishida, Kentaro Mine, Ayana Hioki, et al. Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload. Scientific reports. 2022. 12. 1. 41-41
Hajime Abe, Yohei Tanada, Shigemiki Omiya, Mihai-Nicolae Podaru, Tomokazu Murakawa, Jumpei Ito, Ajay M Shah, Simon J Conway, Masahiro Ono, Kinya Otsu. NF-κB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6Chi monocytes in pressure-overloaded hearts. Science signaling. 2021. 14. 704. eabe4932
種池学, 村川智一, 大津欣也. 【基礎科学の進歩】循環器疾患とオートファジー. 循環器専門医. 2021. 30. 66-72
Masato Ishizuka, Mutsuo Harada, Seitaro Nomura, Toshiyuki Ko, Yuichi Ikeda, Jiaxi Guo, Satoshi Bujo, Haruka Yanagisawa-Murakami, Masahiro Satoh, Shintaro Yamada, et al. CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor. Scientific reports. 2021. 11. 1. 3426-3426

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MISC (26)：

村川智一, 大津欣也. 【心不全のサイエンス治療法開発をめざして心臓の謎を解く】(第2章)心疾患・心不全の分子病態の最先端心臓リモデリングにおけるオートファジーの役割. 実験医学. 2019. 37. 5. 719-724
Tomokazu Murakawa, Osamu Yamaguchi, Koji Okamoto, Yasushi Sakata, Kinya Otsu. The Novel Mitophagic Receptor Protein, Bcl2-like Protein 13: New Insights for the Molecular Mechanisms of the Pathogenesis of Heart Disease. JOURNAL OF CARDIAC FAILURE. 2015. 21. 10. S147-S147
岡崇史, 山口修, 大津欣也. 【心不全フロンティア(薬物療法〜iPS細胞)】最近のトピックス炎症は心不全の原因か?. Cardiac Practice. 2013. 24. 3. 189-193
中山博之, 岡崇史, 山口修, 大津欣也. ミトコンドリア応答性から見る細胞機能解析ミトコンドリア研究の新しい視点オートファジーを免れたミトコンドリアDNAの蓄積は心臓において炎症と心不全を惹起する. 日本生化学会大会プログラム・講演要旨集. 2012. 85回. 2S16-4
Takahito Tamai, Tomokazu Murakawa, Osamu Yamaguchi, Shungo Hikoso, Issei Komuro, Kinya Otsu. The Role of Rheb-mTORC1 Pathway in Cardiac Developmental Growth and Pathological Hypertrophy. CIRCULATION RESEARCH. 2012. 111. 4

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Education (1)：

- 1983 Osaka University Faculty of Medicine

Work history (9)：

2018/04/01 - 現在 Osaka University Graduate School of Medicine Specially Appointed Professor
2012/01 - 現在 King’s College London School of Cardiovascular Medicine and Sciences
2011/04/01 - 2011/12/31 Osaka University Graduate School of Medicine Division of Medicine Associate Professor
2007/04/01 - 2011/03/31 Osaka University Division of Internal Medicine Associate Professor
2005/09/01 - 2007/03/31 Osaka University Division of Internal Medicine Associate Professor

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Awards (5)：

2016 - Academy of Medical Sciences Fellow
2016 - International Society of Heart Research Fellow
2015 - International Society for Heart Research Janice Pfeffer Distinguished Lecture Award
1987 - NIH Visiting Fellowship Award
1983 - 楠本賞

Association Membership(s) (4)：

American Biophysical Society , 日本生化学学会 , 日本内科学会 , 日本循環器病学会

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