Takeshima Yusuke

タケシマユウスケ | Takeshima Yusuke

Affiliation and department：

Research field (3)： Biological, health, and medical informatics , Immunology , Allergies and connective tissue disease

Research theme for competitive and other funds (3)：

2024 - 2026 トランスオミクス解析による自己免疫疾患における制御性T細胞の病態寄与解明
2022 - 2025 Elucidation of immune and allergic disease dynamics by integrative sequencing analysis
2022 - 2024 Elucidation of Signaling Mechanisms Involved in Human Regulatory T Cell Differentiation by Multi-omics Analysis

Papers (23)：

Yoshiaki Yasumizu, Daiki Takeuchi, Reo Morimoto, Yusuke Takeshima, Tatsusada Okuno, Makoto Kinoshita, Takayoshi Morita, Yasuhiro Kato, Min Wang, Daisuke Motooka, et al. Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases. Cell Genomics. 2024. 100473-100473
Ryuya Edahiro, Yuya Shirai, Yusuke Takeshima, Shuhei Sakakibara, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Yu-Chen Liu, Daisuke Motooka, et al. Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity. Nature Genetics. 2023. 55. 5. 753-767
Saeko Yamada, Yasuo Nagafuchi, Min Wang, Mineto Ota, Hiroaki Hatano, Yusuke Takeshima, Mai Okubo, Satomi Kobayashi, Yusuke Sugimori, Nakano Masahiro, et al. Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance. Annals of the Rheumatic Diseases. 2023. 82. 6. 809-819
Yusuke Sugimori, Yukiko Iwasaki, Yusuke Takeshima, Mai Okubo, Satomi Kobayashi, Hiroaki Hatano, Saeko Yamada, Masahiro Nakano, Ryochi Yoshida, Mineto Ota, et al. Transcriptome Profiling of Immune Cell Types in Peripheral Blood Reveals Common and Specific Pathways Involved in the Pathogenesis of Myositis-Specific Antibody-Positive Inflammatory Myopathies. ACR Open Rheumatology. 2023. 5. 2. 93-102
Yuta Yamaguchi, Yasuhiro Kato, Ryuya Edahiro, Jonas N. Søndergaard, Teruaki Murakami, Saori Amiya, Shinichiro Nameki, Yuko Yoshimine, Takayoshi Morita, Yusuke Takeshima, et al. Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells. JCI Insight. 2022. 7. 22

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MISC (4)：

西脇彩, 駒井俊彦, 永渕泰雄, 永渕泰雄, 太田峰人, 太田峰人, 吉田良知, 波多野裕明, 大久保麻衣, 小林聖美, et al. IgG4関連疾患における末梢血免疫担当細胞サブセットとBCRレパトア解析. 日本臨床免疫学会総会プログラム・抄録集. 2021. 49th
Haruyuki Yanaoka, Yasuo Nagafuchi, Yusuke Takeshima, Mineto Ota, Harumi Shirai, Yusuke Sugimori, Mai Okubo, Satomi Kobayashi, Tomohisa Okamura, Yukiko Iwasaki, et al. CHARACTERIZATION OF IMMUNE CELL SUBSETS IN PATIENTS WITH ANCA-ASSOCIATED VASCULITIS. RHEUMATOLOGY. 2017. 56. 116-116
Y. Takeshima, Y. Iwasaki, R. Kato, S. Sumitomo, H. Shirai, B. Natsumoto, M. Otal, S. Teruya, H. Tsuchiya, T. Komai, et al. IMMUNOSUPPRESSIVE THERAPY IS PROMISING FOR PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONNECTIVE TISSUE DISEASE (CTD-PAH). ANNALS OF THE RHEUMATIC DISEASES. 2015. 74. 1079-1079
NAKACHI SHIN'ICHIRO, SUMITOMO SHUJI, TAKESHIMA YUSUKE, INOUE MARIKO, SAKURAI KEIICHI, TSUCHIDA YUMI, IWASAKI YUKIKO, SHIBUYA MIHOKO, SHODA HIROFUMI, KUBO KANAE, et al. 好酸球増多を伴った,抗PL-12抗体・抗SS-A/Ro-52抗体陽性の抗ARS抗体症候群の3例. 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集. 2013. 57th-22nd. 597-597

Books (6)：

ケースでわかるリウマチ・膠原病診療ハンドブック
羊土社 2021
SLEの病態形成におけるミトコンドリアの関与
月刊臨床免疫・アレルギー科 2020
リウマチクリニック Vol.31
メディカルレビュー 2020
日常診療に活かす診療ガイドラインUP-TO-DATE 2016-2017
メディカルレビュー社 2016
膠原病症状に対する診断的アプローチ神経・筋症状下肢の筋力低下
Hospitalist 2(2) 2014

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Lectures and oral presentations (57)：

Integrative plasma metabolome and transcriptome analysis revealed the importance of histidine homeostasis in SLE pathogenesis with potential for improved SLE patients stratification.
(EULAR (European League Against Rheumatism) Annual European Congress of Rheumatology. 2020)
IgG4関連疾患における末梢血免疫担当細胞のサブセットの検討
(日本臨床免疫学会総会プログラム・抄録集 2020)
Multi-omics approaches to immune cell subsets in PBMCs reveals novel insights into type I IFN signature in SLE
(日本免疫不全・自己炎症学会総会・学術集会プログラム・抄録集 2020)
ループス様病態におけるJuxtaposed with another zinc finger gene 1(JAZF1)遺伝子機能の解明
(日本リウマチ学会総会・学術集会プログラム・抄録集 2020)
機能ゲノム学による多彩な膠原病へのアプローチ
(日本リウマチ学会総会・学術集会プログラム・抄録集 2020)

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Education (3)：

2014 - 2018 The University of Tokyo Graduate School of Medicine Department of Allergy and Rheumatology
2007 - 2011 The University of Tokyo Faculty of Medicine School of Medicine
2005 - 2007 The University of Tokyo College of Arts and Sciences Natural Sciences III

Professional career (2)：

博士(医学) (東京大学)
学士(医学) (東京大学)

Work history (4)：

2020/04 - 現在 Osaka University WPI Immunology Frontier Research Center Specially Appointed Assistant Professor
2018/04 - 2020/03 The University of Tokyo Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine Project Assistant Professor
2013/04 - 2014/03 Teikyo University Chiba Medical Center Division of Rheumatology Senior Resident
2011/04 - 2013/03 The University of Tokyo Hospital Junior Resident

Awards (7)：

2018/12 - the Japanese Society for Immunology Best Presentation Award Immune cell-type specific multi-omics analysis revealed contribution of mitochondria in Bcells to systemic lupus erythematosus.
2018/04 - the Japan College of Rheumatology ICW Excellent Abstract Award Multi-omics analysis of immune cell subsets for revealing the pathogenesis of systemic lupus erythematosus
2017/12 - the Japanese Society for Immunology Best Presentation Award Comprehensive analysis of genome and transcriptome analysis of immune cell subsets in peripheral blood mononuclear cells (PBMCs) revealed mitochondria contribution in B cells to systemic lupus erythematosus.
2017/04 - the Japan College of Rheumatology International Workshop Award Cell type-specific RNA-seq of peripheral blood mononuclear cells (PBMCs) revealed mitochondria contribution in B cells to systemic lupus erythematosus.
2017/04 - Japan Society of Molecular Medicine Academic Encouragement Award Approach for elucidation of systemic lupus erythematosus pathogenesis utilizing next generation sequencer

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Association Membership(s) (4)：

Japanese Society for Immunology , The Japanese Society of Clinical Immunology , Japan College of Rheumatology , The Japanese Society of Internal Medicine

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