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J-GLOBAL ID：202001020764885314   Update date: Oct. 24, 2024

Michiue Hiroyuki

ミチウエ ヒロユキ | Michiue Hiroyuki
Affiliation and department：
岡山大学 中性子医療研究センター

About 岡山大学 中性子医療研究センター


Job title： 准教授
Research field  (7)： Nanobioscience ,  Tumor biology ,  Dermatology ,  Pharmaceuticals - chemistry and drug development ,  Digestive surgery ,  Tumor diagnostics and therapeutics ,  Neurosurgery
Research keywords  (15)： Immune combination therapy ,  Malignant melanoma ,  Boron drug ,  drug delivery system ,  blood brain barrier ,  actin polymerization ,  cancer stem cell ,  brain tumor stem cell ,  cell invasion ,  cell penetrating peptide ,  peptide discovery ,  drug repositioning ,  glioblastoma ,  malignant brain tumor ,  BNCT Boron Neutron Capture Therapy
Research theme for competitive and other funds  (25)：
  • 2023 - 2026 皮膚血管肉腫に対するホウ素中性子捕捉療法(BNCT)複合免疫療法の開発
  • 2022 - 2025 予後不良18F-FDG-PET高値膵癌を標的としたホウ素中性子捕捉療法
  • 2022 - 2025 膵がん微小環境を標的としたホウ素中性子捕捉療法の開発
  • 2022 - 2025 Animal model of chronic traumatic encephalopathy and intra-arterial stem cell transplantation: Alteration in tau protein and gene expression
  • 2022 - 2025 Optimized protocol with electrical stimulation and rehabilitation for cell transplantation against cerebral ischemia
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Papers (87)：
  • Nobushige Tsuboi, Yoshihiro Otani, Atsuhito Uneda, Joji Ishida, Yasuki Suruga, Yuji Matsumoto, Atsushi Fujimura, Kentaro Fujii, Hideki Matsui, Kazuhiko Kurozumi, et al. New Anti-Angiogenic Therapy for Glioblastoma With the Anti-Depressant Sertraline. Cancer medicine. 2024. 13. 20. e70288
  • Takuya Fujimoto, Osamu Yamasaki, Noriyuki Kanehira, Hirokazu Matsushita, Yoshinori Sakurai, Naoya Kenmotsu, Ryo Mizuta, Natsuko Kondo, Takushi Takata, Mizuki Kitamatsu, et al. Overcoming immunotherapy resistance and inducing abscopal effects with boron neutron immunotherapy (B-NIT). Cancer science. 2024
  • Takuya Fujimoto, Fuminori Teraishi, Noriyuki Kanehira, Tomoyuki Tajima, Yoshinori Sakurai, Natsuko Kondo, Masahiro Yamagami, Atsushi Kuwada, Akira Morihara, Mizuki Kitamatsu, et al. BNCT pancreatic cancer treatment strategy with glucose-conjugated boron drug. Biomaterials. 2024. 309. 122605-122605
  • Tianyun Zhou, Kazuyo Igawa, Tomonari Kasai, Takuya Sadahira, Wei Wang, Tomofumi Watanabe, Kensuke Bekku, Satoshi Katayama, Takehiro Iwata, Tadashi Hanafusa, et al. The current status and novel advances of boron neutron capture therapy clinical trials. American journal of cancer research. 2024. 14. 2. 429-447
  • Yoshihide Hattori, Tooru Andoh, Shinji Kawabata, Naonori Hu, Hiroyuki Michiue, Hiroyuki Nakamura, Takahiro Nomoto, Minoru Suzuki, Takushi Takata, Hiroki Tanaka, et al. Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy. Journal of radiation research. 2023. 64. 6. 859-869
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MISC (39)：
  • 道上宏之, 道上宏之, 坪井伸成, 坪井伸成, 大谷理浩, 畝田篤仁, 駿河和城, 松本悠司, 石田穣治, 藤井謙太郎, et al. New anti-angiogenic therapy with the anti-depressant toward tumor derived endothelial cells (TDECs). 日本脳腫瘍学会学術集会プログラム・抄録集. 2023. 41st
  • 森原聡, 田嶋智之, 道上宏之, 高口豊. Synthesis of Dodecaborate-Glucose Conjugate for Effective Delivery in Boron Neutron Capture Therapy. 基礎有機化学討論会要旨集. 2023. 33rd (CD-ROM)
  • 桑田淳司, 田嶋智之, 山神将大, 森原聡, 藤本卓也, 道上宏之, 高口豊. Synthesis of Dodecaborate-Glucose Conjugate for Effective Delivery in Boron Neutron Capture Therapy. ホスト-ゲスト・超分子化学シンポジウム講演要旨集. 2022. 19th
  • 桑田淳司, 山神将大, 森原聡, 藤本卓也, 金平典之, 道上宏之, 高口豊, 田嶋智之. ドデカボレート-グルコース複合体の合成とホウ素中性子補足療法への応用. 有機典型元素化学討論会講演要旨集. 2022. 49th (CD-ROM)
  • 藤本翔夢, 井上健, 北松瑞生, 道上宏之. Evaluation of reaction between boron cluster BSH and chloroacetyl-modified tripeptides. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
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Patents (20)：
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Lectures and oral presentations  (38)：
  • Drug Discovery Strategy for Precision BNCT
    (The 7th Symposium of Okayama University Neutron Therapy Research Center 2023)
  • 腫瘍由来血管内皮細胞(TDEC)を標的とした抗うつ薬による新規抗血管新生薬創薬
    (第41回日本脳腫瘍学会学術大会 2023)
  • Novel Cancer Treatment Strategies by BNCT (Boron Neutron Capture Therapy) -Current Status, Problems, and Solutions-
    (Shanghai University-Okayama University Medical Exchange Day, the second Sino-Japanese University Medical Academic Forum 2023)
  • Precision BNCT for Novel Boron Drug Discovery
    (The 19th Congress on Neutron Capture Therapy 2023)
  • Boron drug development for Precision BNCT.
    (2022)
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Education (2)：
  • 1999 - 2005 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences doctor course
  • 1993 - 1999 Okayama University Medical School Faculty of Medicine
Work history (8)：
  • 2022/04 - 現在 Okayama University Neutron Therapy Research Center
  • 2017/04 - 現在 Okayama University Neutron Therapy Research Center Associate Professor
  • 2010/04 - 2017/03 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences Assistant Professor
  • 2007/11 - 2010/03 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences Assistant Professor
  • 2005/06 - 2007/10 University of California, San Diego School of medicine Research Associate
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Committee career (3)：
  • 2021/03 - 現在 ナノ・バイオ融合によるエネルギー集積・高度利用研究拠点形成 シンポジウムオーガナイザー
  • 2020/06 - 現在 Japanese Society of Neutron Capture Therapy member of committee
  • 2014/04 - 現在 日本生理学会中国四国支部 中国四国支部幹事
Awards (5)：
  • 2015/05 - 15th International Congress of Radiation Research 15th International Congress of Radiation Research Excellent Poster Award The Development of BSH Fused Cell-penetrating Peptide towards Clinical Application
  • 2014/06 - Okayama Medical Association Yuuki Award in Okayama Medical Association The acceleration of boron neutron capture therapy using multi-linked mercaptoundecahydrododecaborate (BSH) fused cell-penetrating peptide.
  • 2010/11 - The Physiological Society of Japan Research Award in The Physiological Society of Japan in CHUGOKU Novel siRNA delivery system with protein transduction method
  • 2006/06 - Okayama Medical Association Yamada Prize in Okayama Medical Association
  • 2005/01 - The 3rd Campus Venture Grand Prix in CHUGOKU President's Award of the Economic Federation of CHUGOKU
Association Membership(s) (6)：
The Japan Cancer Association ,  Japanese Society of Neutron Capture Therapy ,  Physiological Society of Japan ,  The Japan Society for Neuro-Oncology ,  The Japan Stroke Society ,  The Japan Neurosurgical Society
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