Yamaguchi Kazuhiko

ヤマグチカズヒコ | Yamaguchi Kazuhiko

Affiliation and department：
Job title：客員研究員

Research field (1)： Basic brain sciences

Research keywords (10)： Neurophysiology , Patch-clamp recording , LTD , memory , motor learning , Purkinje cell , AMPA-receptor , receptor trafficking , synaptic plasticity , cerebellum

Research theme for competitive and other funds (15)：

2017 - 2020 Elucidation of motor learning strategy via two types of the cerebellar synaptic plasticity
2011 - 2013 Elucidation of molecular mechanism of synaptic plasticity by kinetic analysis of receptor trafficking
2008 - 2010 Elucidation of regulatory mechanism of AMPA-receptor's trafficking by visualization of its intracellular pool.
2001 - 2002 新規リソホスファチジル酸アシル基転移酵素エンドフィリンのシナプス伝達における役割
1997 - 1998 Elucidation of molecular mechanism of synaptic exocytosis and its modification mechanism in mammalian hippocampal autapse.

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Papers (49)：

Hiroshi Mitoma, Jerome Honnorat, Kazuhiko Yamaguchi, Mario Manto. Cerebellar long-term depression and auto-immune target of auto-antibodies: the concept of LTDpathies. Molecular Biomedicine. 2021. 2. 1
Hiroshi Mitoma, Jerome Honnorat, Kazuhiko Yamaguchi, Mario Manto. Fundamental Mechanisms of Autoantibody-Induced Impairments on Ion Channels and Synapses in Immune-Mediated Cerebellar Ataxias. International Journal of Molecular Sciences. 2020. 21. 14. 4936-4936
Kazuhiko Yamaguchi, Masao Ito. Assessment of Long-term Depression Induction in Adult Cerebellar Slices. Journal of Visualized Experiments. 2019. 152
Naoko Morimura, Hiroki Yasuda, Kazuhiko Yamaguchi, Kei-ichi Katayama, Minoru Hatayama, Naoko H. Tomioka, Maya Odagawa, Akiko Kamiya, Yoshimi Iwayama, Motoko Maekawa, et al. Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice. Nature Communications. 2017. 8. 1. 15800-15800
Kazuhiko Yamaguchi, Shigeyoshi Itohara, Masao Ito. Reassessment of long-term depression in cerebellar Purkinje cells in mice carrying mutated GluA2 C terminus. Proceedings of the National Academy of Sciences. 2016. 113. 36. 10192-10197

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Books (9)：

発達障害学校で困った子?
ジャパンマシニスト 2019
分子・細胞・シナプスからみる脳
東京大学出版会 2008
脳神経科学イラストレイテッド
羊土社 2006
Slow synaptic responses and modulation
Springer 2000
Neural development
Springer 1999

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Lectures and oral presentations (15)：

小脳機能の基礎研究:現状と展望
(小脳研究会 2020)
小脳の長期抑圧LTDは運動学習に必須か?
(第13回 MotorControl 研究会 2019)
パッチクランプ法を用いたアッセイ系の構築-自己免疫性小脳失調症研究の新たな展開
(NCNP セミナー 2019)
Mechanism of long-term synaptic plasticity in rat cerebellar Purkinje cell.
(75th Fujihara Seminar “The cerebellum as a CNS hub ” 2018)
小脳LTD研究の過去・現在・未来
(小脳システム研究会セミナー 2018)

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Education (5)：

1980 - 1984 The University of Tokyo Graduate School of Medicine Doctoral Program
1977 - 1980 The University of Tokyo Graduate School of Science Doctoral Program Department of Biology
1975 - 1977 The University of Tokyo Graduate School of Science Department of Biology
1973 - 1975 The University of Tokyo Faculty of Science Department of Biological Sciences
1971 - 1973 The University of Tokyo College of Arts and Sciences

Work history (6)：

2019/04 - 現在 National Center of Neurology and Psychiatry National Institute of Neuroscience, Ncnp Guest researcher
2013/04 - 2019/03 RIKEN Center for Brain Science Researcher
1999/04 - 2013/03 RIKEN Brain Science Institute Deputy Laboratory Head
1993/09 - 1999/03 Kyorin University Department of Physiology, School of School of Medicine Associated professor
1985/12 - 1993/08 National Institute for Physiological Sciences Department of Biosystems Research assistant

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