Research field (2)：
Synthetic organic chemistry
, Pharmaceuticals - chemistry and drug development
Research keywords (4)：
膜透過性ペプチド
, ホウ素中性子捕捉療法(BNCT)
, ドラッグデリバリーシステム(DDS)
, ペプチド合成
Research theme for competitive and other funds (2)：
2021 - 2024 The use of nucleic acid aptamers as a removable masking agent for the controlled polymer modification of enzymes
2020 - 2022 Design and development of artificial scaffolds capturing vascular endothelial progenitor cells with high efficiency for accelerating endothelialization
Papers (3)：
Aoi Isono, Mieko Tsuji, Yu Sanada, Akari Matsushita, Shinichiro Masunaga, Tasuku Hirayama, Hideko Nagasawa. Design, Synthesis, and Evaluation of Lipopeptide Conjugates of Mercaptoundecahydrododecaborate for Boron Neutron Capture Therapy. ChemMedChem. 2019. 14. 8. 823-832
Takahiko Imai, Keisuke Mishiro, Toshinori Takagi, Aoi Isono, Hideko Nagasawa, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara. Protective Effect of Bendavia (SS-31) Against Oxygen/Glucose-Deprivation Stress-Induced Mitochondrial Damage in Human Brain Microvascular Endothelial Cells. Current neurovascular research. 2017. 14. 1. 53-59
Mieko Tsuji, Satoshi Ueda, Tasuku Hirayama, Kensuke Okuda, Yoshiaki Sakaguchi, Aoi Isono, Hideko Nagasawa. FRET-based imaging of transbilayer movement of pepducin in living cells by novel intracellular bioreductively activatable fluorescent probes. Organic & biomolecular chemistry. 2013. 11. 18. 3030-7
MISC (2)：
Isono A, Okuda K, Hirayama T, Masunaga S, Nagasawa H. Development of Nuder-targeting Boron Carriers Based on the Chemistry of Direct Cell-penetrating Pepducins. Progress Report 2014, The Research Reactor Institute, Kyoto University. 2015. 5
Isono A, Okuda K, Hirayama T, Masunaga S, Nagasawa H. Design and Synthesis of a New Membrane Peameable Boron Carrier Using the Lipidated Peptide Vehicle. Progress Report 2013, The Research Reactor Institute, Kyoto University. 2014. 121
Lectures and oral presentations (8)：
Desing and synthesis of new membrane permeable boron carriers for BNCT based on pepducin technology
(9th Young Researchers' BNCT Meeting 2017)
Design and synthesis of new boron carriers based on pepducin chemistry and evaluation of their subcellular distribution
(2015)
Design, synthesis and fluorescence imaging of new membrane permeable boron carrier based on the pepducin chemistry
(15th International Congress of Radiation Research (ICRR) 2015)
