Mu Anfeng

ムアンホウ | Mu Anfeng

Affiliation and department：

Research field (4)： Genomics , Medical biochemistry , Genetics , Molecular biology

Research theme for competitive and other funds (6)：

2023 - 2026 Fanconi anemia経路に着目したiPS細胞における高レベル複製ストレスの原因解明
2021 - 2023 骨髄不全症モデルiPS細胞におけるADH5/ALDH2に着目した病態・治療法検討
2020 - 2023 Genome-stabilizing activity of aldehyde catalyzing enzymes that support epigenetic reprogramming
2020 - 2023 The role of SLFN11 gene that determines DNA damage sensitivity at the stalled replication forks
2022 - 2023 SLFN11とクロマチン制御因子の機能的相互作用解明

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Papers (16)：

Anfeng Mu, Yusuke Okamoto, Yoko Katsuki, Minoru Takata. The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway. DNA Repair. 2024. 103733-103733
Erin Alvi, Ayako L. Mochizuki, Yoko Katsuki, Minori Ogawa, Fei Qi, Yusuke Okamoto, Minoru Takata, Anfeng Mu. Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response. Communications Biology. 2023
Anfeng Mu, Zimu Cao, Denggao Huang, Hiroshi Hosokawa, Shingo Maegawa, Minoru Takata. Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model. Molecular Biology Reports. 2023
Anfeng Mu, Asuka Hira, Minako Mori, Yusuke Okamoto, Minoru Takata. Fanconi Anemia and Aldehyde Degradation Deficiency Syndrome: metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA Damage. DNA Repair. 2023. 103546-103546
Fei Qi, Erin Alvi, Minori Ogawa, Junya Kobayashi, Anfeng Mu, Minoru Takata. The ribonuclease domain function is dispensable for SLFN11 to mediate cell fate decision during replication stress response. Genes to Cells. 2023

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MISC (2)：

牟安峰, 高田穣. aldehyde degradation deficiency(ADD)症候群:アルデヒド代謝酵素ADH5/ALDH2欠損による新規遺伝性再生不良性貧血. 生化学. 2022. 94. 1. 122-127
牟安峰, 高田穣. iPS細胞を用いたファンコニ貧血研究の新展開. 血液内科. 2021. 83. 6. 824-829

Lectures and oral presentations (8)：

Insights into the Schlafen gene family-Functional parallels in mice and humans
(Cold Spring Harbor Asia-2024 DNA Metabolism, Genomic Stability & Human Diseases 2024)
SLFN11 promotes fork degradation during the replication stress
(2023)
Fanconi anemia and Aldehyde Degradation Deficiency (ADD) Syndrome.
(2023)
Fanconi anemia and Aldehyde Degradation Deficiency (ADD) Syndrome: DNA repair and metabolism together protect the genome and hematopoiesis.
(2023)
新規骨髄不全症ADDSの発見とモデルiPS細胞による病態・治療法検討
(第17回血液学若手研究者勉強会(麒麟塾) 2022)

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Education (2)：

Work history (4)：

Association Membership(s) (2)：

日本放射線影響学会 , 日本分子生物学会

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