Rchr
J-GLOBAL ID：202101000354461963
Update date: Apr. 25, 2024
Ohgita Takashi
オオギタ タカシ | Ohgita Takashi
Affiliation and department：
Job title：
Assistant professor
Research field (1)：
Pharmaceuticals - analytical and physicochemistry
Research theme for competitive and other funds (4)：
- 2021 - 2024 アミロイド凝集核を構成する異常型αシヌクレインの構造特性の物理化学的解明
- 2016 - 2019 Research for bacterial type III secretion system based on needle rotation model
- 2015 - 2017 Development of pH-sensitive flagellar driven type-liposomes penetrable into tumor tissue
- 2014 - 2016 Evaluation of correlation between rotation and secretion of type III secretion apparatus for clarifying the effector secretion mechanism
Papers (33)：
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Takashi Ohgita, Koto Sakai, Nodoka Fukui, Norihiro Namba, Miyu Nakano, Yuki Kiguchi, Izumi Morita, Hiroyuki Oyama, Kouya Yamaki, Kohjiro Nagao, et al. Generation of novel anti-apoE monoclonal antibodies that selectively recognize apoE isoforms. FEBS letters. 2024. 598. 8. 902-914
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Serina Gima, Kazuya Oe, Kaneyasu Nishimura, Takashi Ohgita, Haruka Ito, Hiroyuki Kimura, Hiroyuki Saito, Kazuyuki Takata. Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons. Regenerative Therapy. 2024. 25. 229-237
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Norihiro Namba, Takashi Ohgita, Hiroko Tamagaki-Asahina, Kazuchika Nishitsuji, Toshinori Shimanouchi, Takeshi Sato, Hiroyuki Saito. Amyloidogenic 60-71 deletion/ValThr insertion mutation of apolipoprotein A-I generates a new aggregation-prone segment that promotes nucleation through entropic effects. Scientific Reports. 2023. 13. 1
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Yuki Takechi-Haraya, Takashi Ohgita, Akiko Usui, Kazuchika Nishitsuji, Kenji Uchimura, Yasuhiro Abe, Ryuji Kawano, Monika I. Konaklieva, Mart Reimund, Alan T. Remaley, et al. Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability. 2023
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Takashi Ohgita, Hiroki Kono, Izumi Morita, Hiroyuki Oyama, Toshinori Shimanouchi, Norihiro Kobayashi, Hiroyuki Saito. Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein. Scientific reports. 2023. 13. 1. 10885-10885
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MISC (7)：
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Takashi Ohgita, Hiroki Kono, Norihiro Namba, Hiroyuki Saito. Physicochemical mechanisms of aggregation and fibril formation of α-synuclein and apolipoprotein A-I. Biophysics and physicobiology. 2024. 21. 1
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MIZUGUCHI-FUKASE Chiharu, OHGITA Takashi, SAITO Hiroyuki. Kinetic and Thermodynamic Analyses of Aggregation and Fibril Formation of Amyloidogenic Proteins. Seibutsu Butsuri. 2022. 62. 4. 224-227
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加藤くみ子, 八幡志穂, 原矢佑樹, 扇田隆司, 出水庸介, 斎藤博幸, 伊豆津健一. Nanoparticle tracking analysis for characterization of extracellular vesicles including exosomes. Pharm Tech Japan. 2022. 38. 2
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Mizuguchi Chiharu, Ohgita Takashi, Saito Hiroyuki. Mechanisms of Aggregation and Amyloid Fibril Formation of Apolipoproteins on Lipid Membranes. MEMBRANE. 2021. 46. 1. 25-31
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小谷真菜, 田村悠樹, 扇田隆司, 原矢佑樹, 西辻和親, 内村健治, 長谷川功紀, 加藤くみ子, 赤路健一, 斎藤博幸. ApoE糖鎖結合ドメイン改変型両親媒性アルギニンペプチドの細胞膜透過機構. 日本薬学会年会要旨集(CD-ROM). 2019. 139th. 2. ROMBUNNO.22PO-am128S-249
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Books (1)：
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ベーシック薬学教科書シリーズ3 物理化学 (第2版)
化学同人 2018
Lectures and oral presentations (50)：
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ライトシート顕微鏡を用いたα-シヌクレインの脳内伝播の空間的可視化法の解析
(日本薬学会第143年会 2023)
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新規抗アポEモノクローナル抗体のアポEアイソフォーム反応特性の物理化学的評価
(日本薬学会第143年会 2023)
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ApoA-Iの構造安定性とアミロイド線維形成性に及ぼすアミロイドーシス変異の影響
(日本薬学会第143年会 2023)
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アミロイド共存タンパク質ApoA-IVの物性とアミロイド線維形成促進効果
(日本薬学会第143年会 2023)
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Bacopa monnieraに含有されるAβ結合物質plantainoside BによるAβ凝集体の検出と神経保護作用
(日本薬学会第143年会 2023)
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