Rchr
J-GLOBAL ID：202101000363244002
Update date: May. 14, 2024
Kumamoto Hiroki
クマモト ヒロキ | Kumamoto Hiroki
Affiliation and department：
Job title：
Associate Professor
Research theme for competitive and other funds (2)：
- 2006 - 2007 新規SAHase 阻害剤;塩基部,糖部修飾型ヌクレオシドの合成と生物活性の探索
- 2003 - 2004 糖部2',3'炭素置換d4ヌクレオシドの新規合成法の開発と抗HIV活性の探索
Papers (72)：
-
Kazuhiro Haraguchi, Hiroki Kumamoto, Shuhei Imoto, Nobuyo Kuwata-Higashi, Hiroaki Mitsuya. Regio- and Stereoselective Synthesis of 2′-Deoxy-4′-thioguanine Nucleosides: Evaluation of Anti-Hepatitis B Virus Activity and Cytotoxicity Leading to Improved Selectivity Index by 4′-C-Cyanation. Synlett. 2023. 35. 06. 728-733
-
Yuki Takamatsu, Sanae Hayashi, Hiroki Kumamoto, Shuhei Imoto, Yasuhito Tanaka, Hiroaki Mitsuya, Nobuyo Higashi-Kuwata. A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes. Virus research. 2023. 329. 199094-199094
-
Hiroki Kumamoto, Nobuyo Higashi-Kuwata, Sanae Hayashi, Debananda Das, Haydar Bulut, Ryoh Tokuda, Shuhei Imoto, Kengo Onitsuka, Yuka Honda, Yuki Odanaka, et al. Synthesis of novel entecavir analogues having 4′-cyano-6′′-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent. RSC Advances. 2023. 13. 23. 15999-16011
-
Kazuhiro Haraguchi, Noyori Hannda, Mizuki Wakasugi, Madoka Maruyama, Hirokazu Ishii, Daisuke Nagano, Hiroki Kumamoto. DAST-Mediated Fluorination of 1-[4-Thio-β-d-arabinofuranosyl]uracil: Investigation of Thiolane vs Thietane Formation and Stereoselective Synthesis of 4′-ThioFAC. Synthesis. 2022. 54. 24. 5509-5519
-
Kazuhiro Haraguchi, Hiroki Kumamoto, Hiromichi Tanaka. 4-Thiofuranoid Glycal: Versatile Glycosyl Donor for the Selective Synthesis of β-anomer of 4'-thionucleoside and its Biological Activities. Current medicinal chemistry. 2022. 29. 21. 3684-3731
ｍore...
Return to Previous Page
