Rchr
J-GLOBAL ID:202101000539532565   Update date: Aug. 23, 2021

Manabe Tadashi

マナベ タダシ | Manabe Tadashi
Affiliation and department:
Research field  (1): Respiratory medicine
Research keywords  (2): Elucidation of drug resistance mechanisms in lung cancer ,  Establishment of patient-derived cancer models
Research theme for competitive and other funds  (3):
  • 2021 - 2022 Elucidation of the resistant mechanism of molecular inhibitors using lung cancer organoids
  • 2019 - 2021 Development of precision medicine for molecular inhibitor resistant patients using patient-derived cancer cell lines
  • 2017 - 2019 肺癌および間質性肺炎における新規治療標的となるチロシンキナーゼの同定
Papers (8):
  • Hideki Terai, Junko Hamamoto, Katsura Emoto, Takeshi Masuda, Tadashi Manabe, Satoshi Kuronuma, Keigo Kobayashi, Keita Masuzawa, Shinnosuke Ikemura, Sohei Nakayama, et al. SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells. Molecular cancer research : MCR. 2021. 19. 2. 317-328
  • Keigo Kobayashi, Hideki Terai, Hiroyuki Yasuda, Junko Hamamoto, Yuichiro Hayashi, Osamu Takeuchi, Yoichiro Mitsuishi, Keita Masuzawa, Tadashi Manabe, Shinnosuke Ikemura, et al. Functional dissection of the KRAS G12C mutation by comparison among multiple oncogenic driver mutations in a lung cancer cell line model. Biochemical and biophysical research communications. 2021. 534. 1-7
  • Kazuhiro Kakimi, Hirokazu Matsushita, Keita Masuzawa, Takahiro Karasaki, Yukari Kobayashi, Koji Nagaoka, Akihiro Hosoi, Shinnosuke Ikemura, Kentaro Kitano, Ichiro Kawada, et al. Adoptive transfer of zoledronate-expanded autologous Vγ9Vδ2 T-cells in patients with treatment-refractory non-small-cell lung cancer: a multicenter, open-label, single-arm, phase 2 study. Journal for immunotherapy of cancer. 2020. 8. 2
  • Tadashi Manabe, Hiroyuki Yasuda, Hideki Terai, Harumi Kagiwada, Junko Hamamoto, Toshiki Ebisudani, Keigo Kobayashi, Keita Masuzawa, Shinnosuke Ikemura, Ichiro Kawada, et al. IGF2 Autocrine-Mediated IGF1R Activation Is a Clinically Relevant Mechanism of Osimertinib Resistance in Lung Cancer. Molecular cancer research : MCR. 2020. 18. 4. 549-559
  • Ayano Oashi, Hiroyuki Yasuda, Keigo Kobayashi, Tetsuo Tani, Junko Hamamoto, Keita Masuzawa, Tadashi Manabe, Hideki Terai, Shinnosuke Ikemura, Ichiro Kawada, et al. Monomer Preference of EGFR Tyrosine Kinase Inhibitors Influences the Synergistic Efficacy of Combination Therapy with Cetuximab. Molecular cancer therapeutics. 2019. 18. 9. 1593-1601
more...
MISC (11):
  • 眞鍋 維志. みんなで解決! 病棟のギモン 研修医の素朴な質問にお答えします(第47回) プレゼンテーションの技法と作法. レジデントノート. 2020. 21. 16. 2866-2871
  • 眞鍋 維志, 安田 浩之, 小林 慧悟, 増澤 啓太, 浜本 純子, 寺井 秀樹, 川田 一郎, 副島 研造. 患者由来肺癌細胞株の樹立とチロシンキナーゼ阻害薬耐性化機序の解明(Establishment of patient-derived cancer cell lines to elucidate the resistant mechanism of tyrosine kinase inhibitors). 日本癌学会総会記事. 2019. 78回. E-3097
  • 眞鍋 維志, 杉原 快, 光石 彬史, 胡谷 俊樹, 竹原 朋宏, 小林 慧悟, 増澤 啓太, 池村 辰之介, 寺井 秀樹, 安田 浩之, et al. 肺癌 基礎 分子標的薬耐性化後の患者検体を用いた肺癌細胞株の樹立と耐性化機序の解明. 日本呼吸器学会誌. 2019. 8. 増刊. 162-162
  • 眞鍋 維志, 副島 研造. 【がん診療における心血管合併症:onco-cardiologyアップデート】内科で診る機会の多い腫瘍の化学療法と心血管合併症について知る 肺癌. 診断と治療. 2018. 106. 8. 957-961
  • 眞鍋 維志, 胡谷 俊樹, 竹原 朋宏, 小林 慧悟, 増澤 啓太, 長谷川 華子, 安田 浩之, 川田 一郎, 猶木 克彦, 副島 研造, et al. 分子標的薬耐性化後の胸水・腹水検体を用いた癌細胞株の樹立と耐性化機序の解明. 日本呼吸器学会誌. 2018. 7. 増刊. 174-174
more...
Education (2):
  • 2017 - 2020 Keio University Doctoral course (Medicine)
  • 2006 - 2012 Keio University
Professional career (2):
  • 学士(医学) (慶應義塾大学医学部)
  • 博士(医学) (慶應義塾大学医学研究科)
Work history (6):
  • 2021/04 - 現在 University of California, San Francisco Department of Medicine, Division of Hematology/Oncology Postdoctoral Scholar-Fellow
  • 2020/10 - 現在 Keio University School of Medicine Department of Internal Medicine Division of Pulmonary Medicine Co-researcher
  • 2020/04 - 2021/03 Tachikawa Hospital Department of Internal Medicine, Division of Pulmonary Medicine Medical Staff
  • 2017/04 - 2020/03 Keio University School of Medicine Department of Internal Medicine, Division of Pulmonary Medicine Assistant Professor
  • 2014/04 - 2018/03 Keio University School of Medicine Department of Internal Medicine Senior Resident
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Association Membership(s) (6):
Japanese Cancer Association ,  Japanese Society of Medical Oncology ,  The Japan Lung Cancer Society ,  The Japanese Respiratory Society ,  Japanese Society of Respiratory Endoscopy ,  The Japanese Society of Internal Medicine
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