Tomonobu Nahoko

トモノブナホコ | Tomonobu Nahoko

Affiliation and department：

Research field (1)： Medical biochemistry

Research keywords (3)： S100タンパク質 , がん , 細胞生物学

Research theme for competitive and other funds (8)：

2023 - 2026 S100A8/A9-向転移とHRG-抗転移の細胞間・分子間クロストークの解明
2023 - 2026 悪性中皮腫の増殖・転移を加速するCaチャネル活性化を介した新しい分子機構の解明
2023 - 2025 国内発の新しい生物製剤による難治性皮膚炎症性疾患の病態制御
2023 - 2024 がん進展に重要な TRPV2 の新しい活性化分子機構の発見とその解明を基盤とした悪性中皮腫増生の本態理解
2022 - 2024 膵臓がんの線維化と転移を同時制御する新しい治療戦略

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Papers (34)：

Tetta Takahashi, Nahoko Tomonobu, Rie Kinoshita, Ken-ichi Yamamoto, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Youyi Chen, Fan Jiang, Yuma Gohara, Toshiki Ochi, et al. Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface. Frontiers in Oncology. 2024. 14
Hitoshi Murata, May Tha Zin Phoo, Toshiki Ochi, Nahoko Tomonobu, Ken-Ichi Yamamoto, Rie Kinoshita, Ikuko Miyazaki, Masahiro Nishibori, Masato Asanuma, Masakiyo Sakaguchi. Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration. Journal of biochemistry. 2023
Hitoshi Murata, Yu Yasui, Kazuma Oiso, Toshiki Ochi, Nahoko Tomonobu, Ken-Ichi Yamamoto, Rie Kinoshita, Masakiyo Sakaguchi. STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes. Cellular signalling. 2023. 108. 110717-110717
Tong Gao, Xu Yang, Masayoshi Fujisawa, Toshiaki Ohara, Tianyi Wang, Nahoko Tomonobu, Masakiyo Sakaguchi, Teizo Yoshimura, Akihiro Matsukawa. SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells. International journal of molecular sciences. 2023. 24. 5
Yuma Gohara, Nahoko Tomonobu, Rie Kinoshita, Junichiro Futami, Léna Audebert, Youyi Chen, Ni Luh Gede Yoni Komalasari, Fan Jiang, Chikako Yoshizawa, Hitoshi Murata, et al. Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells. Journal of molecular medicine (Berlin, Germany). 2023. 101. 4. 431-447

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MISC (17)：

Akira Yamauchi, Masahiro Yamamura, Naoki Katase, Nahoko Tomonobu, Rie Kinoshita, Masakiyo Sakaguchi, Shuichiro Okamoto. NOX4 on lymphatic endothelial cells (LEC) plays an important role on the migration of pancreatic cancer cells. CANCER SCIENCE. 2021. 112. 347-347
山内明, 山村真弘, 片瀬直樹, 友信奈保子, 木下理恵, 阪口政清, 岡本秀一郎. NOX4 on lymphatic endothelial cells (LEC) plays an important role on the migration of pancreatic cancer cells. 日本癌学会学術総会抄録集(Web). 2020. 79th
合原勇馬, 光井洋介, 友信奈保子, 木下理恵, 山内明, 山村真弘, 近藤英作, 豊岡伸一, 豊岡伸一, 那須保友, et al. Eextracellular S100A11 upregulates mobility of pancreatic cancer cells through activation of surrounding fibroblasts. 日本癌学会学術総会抄録集(Web). 2020. 79th
合原勇馬, 光井洋介, 友信奈保子, 木下理恵, 山本健一, 山内明, 山村真弘, 近藤英作, 豊岡伸一, 那須保友, et al. 分泌性S100A11は膵臓癌の細胞運動性を高める腫瘍周囲の線維芽細胞を活性化する. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
友信奈保子, 木下理恵, 近藤英作, 山内明, 二見淳一郎, 豊岡伸一, 阪口政清. Melanoma cell adhesion molecule (MCAM) induces dissemination of melanoma upon S100A8/A9 binding. 日本癌学会学術総会抄録集(Web). 2019. 78th

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Education (3)：

2017 - 2021 Okayama University
2015 - 2017 Okayama University
2011 - 2015 Osaka Institute of Technology Faculty of Engineering

Professional career (1)：

Medical Science (Okayama University)

Work history (2)：

2021/04 - 岡山大学学術研究院医歯薬学域細胞生物学特任助教
2017/04 - 2021/03 Okayama University

Awards (1)：

2021/09 - 日本組織培養学会第93回大会奨励賞

Association Membership(s) (2)：

日本組織培養学会 , 日本癌学会

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