Rchr
J-GLOBAL ID：202101002155420371
Update date: Aug. 29, 2024
Xu Minhui
ジョ ビンケイ | Xu Minhui
Affiliation and department：
Research field (3)：
Tumor diagnostics and therapeutics
, Urology
, Pharmacology
Research theme for competitive and other funds (1)：
- 2022 - 2025 がん細胞アミノ酸輸送体阻害薬の強力な細胞周期制御の機序と細胞休眠化機構の解明
Papers (21)：
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Ryuichi Ohgaki, Yuma Hirase, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai. LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia. Scientific reports. 2024. 14. 1. 19635-19635
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Yu Ma, Suguru Okuda, Hiroki Okanishi, Minhui Xu, Chunhuan Jin, Hitoshi Endou, Ryuichi Ohgaki, Yoshikatsu Kanai. Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells. Journal of Pharmacological Sciences. 2024. 155. 1. 14-20
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Shinpei Saito, Keisuke Ando, Shinichi Sakamoto, Minhui Xu, Yasutaka Yamada, Junryo Rii, Sanji Kanaoka, Jiaxing Wei, Xue Zhao, Sangjon Pae, et al. The LAT1 inhibitor JPH203 suppresses the growth of castration-resistant prostate cancer through a CD24-mediated mechanism. Cancer science. 2024
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Xinyu Zhou, Ryuichi Ohgaki, Chunhuan Jin, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Yoshikatsu Kanai. Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation. Journal of Pharmacological Sciences. 2024. 154. 3. 182-191
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Sihui Chen, Chunhuan Jin, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai. Structure-activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1). Scientific Reports. 2024. 14. 1
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MISC (9)：
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L-type amino acid transporter 1 inhibitor JPH203 as a new therapeutic target for castration resistant prostate cancer. 2022. 81回. E-3078
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Nishikubo Kou, Ohgaki Ryuichi, Okanishi Hiroki, Okuda Suguru, Xu Minhui, Endou Hitoshi, Kanai Yoshikatsu. Contribution of LAT1 to amino acid uptake in cancer cells and suppression of cellular protein synthesis by LAT1 inhibitor. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 1-SS-50
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坂本信一, 竹内信善, XU Minhui, 鎌田修平, 山田康隆, 木藤宏樹, 松本洋明, 松山豪泰, 小宮顕, 赤倉功一郎, et al. 高齢者における新規アンドロゲン受容体阻害剤の予後予測因子の検討. 日本アンドロロジー学会総会記事. 2017. 36th
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SAKAMOTO Shinichi, XU Minhui, MAIMAITI Marghulan, KANAI Yoshikatsu, ANZAI Naohiko, ICHIKAWA Tomohiko. Up-regulation of LAT1 during androgen deprivation therapy contributes to acquisition of castration resistance in prostate cancer cells. がんと代謝研究会プログラム&抄録集. 2017. 5th
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坂本信一, XU Minhui, 木村徹, 五島悠介, 布施美樹, 川村幸治, 今本敬, 安西尚彦, 金井好克, 関直彦, et al. 新規前立腺癌去勢抵抗性のメカニズムとしてのLAT1の役割. 日本がん分子標的治療学会学術集会プログラム・抄録集. 2016. 20th
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Professional career (1)：
Work history (4)：
- 2021/04 - 現在 Osaka University Graduate School of Medicine
- 2017/11 - 2021/03 Osaka University Graduate School of Medicine
- 2017/05 - 2017/10 千葉大学大学院医学研究科 腫瘍病理学
- 2013/04 - 2017/03 千葉大学大学院医学研究科 泌尿器科学
Awards (1)：
- 2017/06 - 日本アンドロロジー学会学術奨励賞
Association Membership(s) (4)：
日本薬理学
, 日本免疫学会
, 日本アンドロロジー学会
, 日本癌学会
