Rchr
J-GLOBAL ID：202101002619486826   Update date: Aug. 25, 2024

Yamashita Masayuki

ヤマシタ マサユキ | Yamashita Masayuki
Affiliation and department：
Kyoto Pharmaceutical University Pharmaceutical manufacturing chemistry

About Kyoto Pharmaceutical University Pharmaceutical manufacturing chemistry


Job title： professor
Research field  (1)： Pharmaceuticals - chemistry and drug development
Research theme for competitive and other funds  (7)：
  • 2016 - 2023 新規抗がん剤の創製を指向したアセトゲニン誘導体のTHF環部分の構造活性相関研究
  • 2014 - 2017 Establishment of practical determination method of absolute configuration based on induced circular dichroism and quantum chemical approach to elucidation of its origin
  • 2013 - 2017 Structure activity relationships study of dual-core type acetogenin analogues for development of novel antitumor agents
  • 2010 - 2013 Development of novel synthetic reactions based on release of strain energy in small ring system and its application to total syntheses of natural products
  • 2011 - 2013 Development and application of the environmental friendly and highly efficient organic synthesis using characteristics of the heterocycle
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Papers (59)：
  • Hiroki Iwasaki, Mari Ikemoto, Haruka Shibata, Yuka Shima, Erina Himeno, Naoto Kojima, Masayuki Yamashita, Hisanori Nambu. Regioselective SmI<sub>2</sub>-Mediated Radical <i>ipso</i>-Substitution Cyclization for the Construction of Pyrrolophenanthridinone Skeletons: The Synthesis of <i>Amaryllidaceae</i> Alkaloids. Chemical and Pharmaceutical Bulletin. 2023. 71. 7. 515-519
  • Takuya Matsumoto, Saya Okazaki, Shui Aoki, Aya Niki, Hiroki Iwasaki, Minoru Ozeki, Masayuki Yamashita, Naoto Kojima, Ikuo Kawasaki. Facile Synthesis of 5-Alkoxy-4-Aryltetrahydrofuran-2-one Using Hypervalent Iodine Reagents. Tetrahedron Letters. 2023. 118. 154382-154382
  • 細見 紘幸, 小柴 佐和子, 松本 卓也, 上田 拓, 小菅 真央, 飯居 宏美, 中田 晋, 岩崎 宏樹, 山下 正行, 小島 直人. 15-16位をthreo配置に固定したアセトゲニンチオフェン誘導体の構造活性相関研究. 日本薬学会年会要旨集. 2022. 142年会. 27S-pm18S
  • Kaito Ohta, Tetsuya Fushimi, Mutsumi Okamura, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita, Naoto Kojima. Structure-antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety. RSC Advances. 2022. 12. 25. 15728-15739
  • Takahiro Μatsumoto, Daisuke Imahori, Erika Ohnishi, Masaya Okayama, Takahiro Kitagawa, Tomoe Ohta, Tatsusada Yoshida, Naoto Kojima, Masayuki Yamashita, Tetsushi Watanabe. Chemical structures and induction of cell death via heat shock protein inhibition of the prenylated phloroglucinol derivatives isolated from Hypericum erectum. Fitoterapia. 2022. 156. 105097-105097
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MISC (8)：
  • 岩崎宏樹, 野村凜, 山下正行, 小島直人, 南部寿則. Development of one-pot reaction for the synthesis of 1-aminoisoquinoline via isoquinoline N-oxide as reactive intermediate. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 岩崎宏樹, 吉岡虹太, 花木真子, 山下正行, 小島直人, 南部寿則. Development of the cyclization reaction with trifluoroacetamide group as radical precursor mediated by samarium(II) diiodide. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 大田海斗, 藤井真人, 茂山千愛美, 飯居宏美, 中田晋, 岩崎宏樹, 山下正行, 南部寿則, 小島直人. Synthesis and Antitumor Activity of Novel Analog of Acetogenin Thiophene Analog with Triethylene Glycol in place of THF Moiety. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 細見紘幸, 小柴佐和子, 松本卓也, 安藤翔太, 茂山千愛美, 飯居宏美, 中田晋, 岩崎宏樹, 山下正行, 南部寿則, et al. Synthesis of Acetogenin Thiophene Analogs Conformationally Fixed by Cyclopentane Rings and Clarification Research of Molecular Mechanism. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 高橋達哉, 大田海斗, 竜石侑璃, 安藤翔太, 茂山千愛美, 飯居宏美, 中田晋, 岩崎宏樹, 山下正行, 南部寿則, et al. Synthesis of Thiophene Carboxamides with Alkyl Chain Comprising Ethylene Glycol Units, and Their Growth Inhibitory Activity against Glioblastoma Stem Cells. 日本薬学会年会要旨集(Web). 2023. 143rd
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Education (1)：
  • 1975 - 1979 Kyoto Pharmaceutical University
Work history (1)：
  • 1991/05 - 現在 Kyoto Pharmaceutical University
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