Sasaki Takashi

ササキタカシ | Sasaki Takashi

Affiliation and department：

Research field (4)： Food sciences , Applied molecular and cellular biology , Cell biology , Applied biochemistry

Research keywords (7)：カルシウムシグナル , Functional foods , Lipid metabolism , Glucose metabolism , Sarcopenia , Bile acid , Skeletal muscle

Research theme for competitive and other funds (5)：

2023 - 2026 ストア作動性カルシウム流入から解き明かす運動による健康効果の分子機構
2019 - 2024 骨格筋における摂食応答の分子基盤解明と筋機能改善への応用
2019 - 2022 Discovery and functional analysis of a novel E3 ubiquitin ligase that regulates skeletal muscle atrophy under low nutrient condition
2016 - 2018 Analysis of Molecular mechanism underlying improvement of skeletal muscle functions by bile acid.
2014 - 2016 運動による代謝改善効果を模倣する新規代謝調節経路の分子機構解析

Papers (11)：

Takashi Sasaki, Naho Ikari, Shuzo Hashimoto, Ryuichiro Sato. Identification of α-ionone, nootkatone, and their derivatives as TGR5 agonists. Biochemical and Biophysical Research Communications. 2023. 653. 147-152
Takashi SASAKI, Mako OKUDA, Tzu-Wen HONG, Yuichi WATANABE, Yu TAKAHASHI, Makoto SHIMIZU, Yoshio YAMAUCHI, Ryuichiro SATO. Sesamin and Hepatic Metabolites Derived from Sesamin and Episesamin Antagonize Farnesoid X Receptor and Reduce the Expression of Gluconeogenesis-Related Genes. Journal of Nutritional Science and Vitaminology. 2022. 68. 1. 55-64
Shotaro Murata, Takashi Sasaki, Yuki Yamauchi, Makoto Shimizu, Ryuichiro Sato. Maslinic acid activates mTORC1 and human TGR5 and induces skeletal muscle hypertrophy. Bioscience, Biotechnology, and Biochemistry. 2021. 85. 11. 2311-2321
Yuichi Watanabe, Takashi Sasaki, Shoko Miyoshi, Makoto Shimizu, Yoshio Yamauchi, Ryuichiro Sato. Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK/eIF2α/ATF4 axis. Journal of Biological Chemistry. 2021. 297. 2. 100989-100989
Takashi Sasaki, Yuichi Watanabe, Ayane Kuboyama, Akira Oikawa, Makoto Shimizu, Yoshio Yamauchi, Ryuichiro Sato. Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice. Journal of Biological Chemistry. 2021. 296. 100131-100131

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MISC (2)：

Sterol metabolism and skeletal muscle functions:Clinical, nutritional, and pharmacological perspective. Journal of Japanese Biochemical Society. 2021. 93. 1. 15-23
栄田陸人, 桑田啓子, 柴田貴広, 佐々木崇, 高橋裕, 山内祥生, 佐藤隆一郎. The analysis of the E3 ubiquitin ligase RNF122 expression mechanism and function in skeletal muscle. 日本農芸化学会大会講演要旨集(Web). 2021. 2021

Books (2)：

Lectures and oral presentations (5)：

食品による運動模倣の可能性
(2020年度日本農芸化学会大会 2020)
A novel role of bile acids in the regulation of metabolism and muscle function
(2019)
胆汁酸による代謝制御研究の新展開
(第73回日本栄養・食糧学会大会 2019)
Bile acid regulates muscle mass
(2019 International Conference on Functional Food for Metabolic Disorder and Aging 2019)
胆汁酸が担う代謝調節シグナルとしての役割と糖尿病治療への応用
(第61回日本糖尿病学会年次学術集会 2018)

Education (2)：

2010 - 2015 The University of Tokyo Graduate School of Agricultural and Life Sciences Applied Biological Chemistry
2006 - 2010 Tohoku University Faculty of Agriculture Department of Applied Bio-Sciences

Professional career (1)：

Work history (3)：

2023/06 - 現在 The University of Tokyo Graduate School of Agricultural and Life Sciences
2016/04 - 2023/05 The University of Tokyo Graduate School of Agricultural and Life Sciences
2014/04 - 2016/03 The University of Tokyo Graduate School of Agricultural and Life Sciences

Committee career (1)：

Awards (8)：

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Association Membership(s) (6)：

日本筋学会 , 日本糖尿病学会 , 日本肥満学会 , 日本生化学会 , 日本栄養・食糧学会 , 日本農芸化学会

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