Rchr
J-GLOBAL ID：202101002868526773   Update date: Jun. 19, 2024

Taira Nihira Naoe

ニヒラ(タイラ) ナオエ | Taira Nihira Naoe
Affiliation and department：
St.Marianna University School of Medicine Department of Translational Oncology

About St.Marianna University School of Medicine Department of Translational Oncology


Research keywords  (5)： PD-L1 ,  Post-translational modification ,  Immune checkpoint ,  DNA damage response ,  p53
Research theme for competitive and other funds  (15)：
  • 2020 - 2024 Clarification of PD-L1 functions under genotixic stress
  • 2023 - 2024 乳癌における免疫チェックポイント分子PD-L1の機能解明と治療への展開
  • 2021 - 2022 アセチル化・ユビキチン化を標的とした乳癌の新規合成致死療法の開発
  • 2021 - 2022 免疫チェックポイント分子を標的とした乳癌の転移・浸潤制御機構の解明
  • 2021 - 2022 PD-1/PD-L1 による免疫寛容の獲得の分子制御機構の解明
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Papers (20)：
  • Naoe Taira Nihira, Tomohiko Ohta, Zichuan Liu, Xiangpeng Dai. Editorial: Community series in post-translational modifications of proteins in cancer immunity and immunotherapy, volume II. Frontiers in immunology. 2023. 14. 1289016-1289016
  • Jing Zhu, Wenwen Wu, Yukiko Togashi, Naoe Taira Nihira, Yoshikazu Johmura, Dajiang Zhu, Makoto Nakanishi, Yasuo Miyoshi, Tomohiko Ohta. Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance. Breast cancer (Tokyo, Japan). 2022. 29. 6. 1076-1087
  • [筆頭共著] Yang Gao, Naoe Taira Nihira, Xia Bu, Chen Chu, Jinfang Zhang, Aleksandra Kolodziejczyk, Yizeng Fan, Ngai Ting Chan, Leina Ma, Jing Liu, et al. Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nature cell biology. 2020. 22. 9. 1064-1075
  • Nikita Patel, Juehong Wang, Kumiko Shiozawa, Kevin B Jones, Yanfeng Zhang, Jeremy W Prokop, George G Davenport, Naoe T Nihira, Zhenyue Hao, Derek Wong, et al. HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression. iScience. 2019. 13. 43-54
  • Emilie Clement, Hiroyuki Inuzuka, Naoe T Nihira, Wenyi Wei, Alex Toker. Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors. Science signaling. 2018. 11. 521
ｍore...
MISC (4)：
  • Naoe Taira Nihira, Yoshio Miki. Regulation of Intrinsic Functions of PD-L1 by Post-Translational Modification in Tumors. Frontiers in oncology. 2022. 12. 825284-825284
  • Kouhei Shimizu, Naoe Taira Nihira, Hiroyuki Inuzuka, Wenyi Wei. Physiological functions of FBW7 in cancer and metabolism. Cellular signalling. 2018. 46. 15-22
  • Naoe Taira Nihira, Kiyotsugu Yoshida. Engagement of DYRK2 in proper control for cell division. Cell cycle (Georgetown, Tex.). 2015. 14. 6. 802-7
  • N Taira, K Yoshida. Post-translational modifications of p53 tumor suppressor: determinants of its functional targets. Histology and histopathology. 2012. 27. 4. 437-43
Professional career (1)：
  • Ph.D (Tokyo Medical and Dental University)
Work history (10)：
  • 2022/11 - 現在 St.Marianna University School of Medicine
  • 2020/04 - Japan Society for the Promotion of Science
  • 2018/04 - 2020/03 東北大学 歯学研究科 小児発達歯科学分野 非常勤講師
  • 2015/09 - 2018/03 Beth Israel Deaconess Medical Center, Harvard Medical School Instructor
  • 2015/04 - 2017/03 Japan Society for the Promotion of Science
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Awards (5)：
  • 2021/11 - 日本生化学会 奨励賞
  • 2021/10 - 日本癌学会 奨励賞
  • 2011/02 - 財団法人 井上科学振興財団 井上研究奨励賞
  • 2008/02 - 東京医科歯科大学 難治疾患研究所 最優秀論文賞
  • 2007/03 - 東京医科歯科大学大学院 生命情報科学教育部 博士(前期)課程 優秀研究賞
Association Membership(s) (4)：
日本乳癌学会 ,  日本生化学会 ,  アメリカ癌学会 ,  日本癌学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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