J-GLOBAL ID:202101004879360470   Update date: Sep. 05, 2021


Affiliation and department:
Job title: Assistant Professor
Research field  (1): Gastroenterology
Research keywords  (1): inflammatory bowel disease
Research theme for competitive and other funds  (5):
  • 2021 - 2023 Developing a novel treatment for Crohn's colitis by inducing differentiation in intestinal epithelial cells
  • 2019 - 2020 Increased epithelial cell miR-31 expression disrupts the intestinal barrier in Crohn’s Disease
  • 2016 - 2018 Unveiling the impact of disrupted intracellular iron regulation in intestinal macrophages on the pathophysiology of inflammatory bowel disease
  • 2014 - 2017 Role of iron metabolism-related molecule, NGAL, in the pathophysiology of inflammatory bowel disease
  • 2014 - 2015 腸管マクロファージの細胞内鉄を標的とした炎症性腸疾患の病態解明
Papers (28):
  • Takahiko Toyonaga, Taku Kobayashi, Satoshi Kuronuma, Aito Ueno, Hiroki Kiyohara, Shinji Okabayashi, Osamu Takeuchi, Christopher P. F. Redfern, Hideki Terai, Ryo Ozaki, et al. Increased DNA-incorporated thiopurine metabolite as a possible mechanism for leukocytopenia through cell apoptosis in inflammatory bowel disease patients with NUDT15 mutation. Journal of Gastroenterology. 2021
  • Takahiko Toyonaga, Kenza C Araba, Meaghan M Kennedy, Benjamin P Keith, Elisabeth A Wolber, Caroline Beasley, Erin C Steinbach, Matthew R Schaner, Animesh Jain, Millie D Long, et al. Increased colonic expression of ACE2 associates with poor prognosis in Crohn's disease. Scientific reports. 2021. 11. 1. 13533-13533
  • Ryosuke Miyazaki, Toshiyuki Sakurai, Yuko Iwashita, Mariko Shimada, Naoki Shibuya, Yoshihiro Akita, Haruna Miyashita, Yuki Maruyama, Ryoichi Sawada, Takahiko Toyonaga, et al. Characteristics and endoscopic classification of ulcerative lesions affecting the ileocecal valve. Digestive diseases (Basel, Switzerland). 2021
  • Takahiko Toyonaga, Erin C Steinbach, Benjamin P Keith, Jasmine B Barrow, Matthew R Schaner, Elisabeth A Wolber, Caroline Beasley, Jennifer Huling, Yuli Wang, Nancy L Allbritton, et al. Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn's Disease. Cellular and molecular gastroenterology and hepatology. 2020. 10. 4. 779-796
  • Shinji Okabayashi, Taku Kobayashi, Eiko Saito, Takahiko Toyonaga, Ryo Ozaki, Shintaro Sagami, Masaru Nakano, Junichi Tanaka, Keiji Yagisawa, Satoshi Kuronuma, et al. Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis. Intestinal research. 2019. 17. 2. 218-226
MISC (9):
  • 豊永貴彦, 猿田雅之. 炎症性腸疾患と微量ミネラル欠乏. 日本医師会雑誌. 2021. 150. 3. 465-468
  • 豊永貴彦, 櫻井俊之, 猿田雅之. The role of epithelioid granuloma in inflammatory bowel disease. 月刊呼吸器内科. 2020. 38. 6
  • 豊永貴彦, 小林拓, 斉藤詠子, 岡林慎二, 日比紀文. IBD治療のピットフォール 第13回 IBD患者のアドヒアランス不良例. IBD Research. 2017. 11. 1
  • 小林拓, 豊永貴彦, 齊藤詠子, 中野雅, 日比紀文. 炎症性腸疾患 徹底解説!抗TNF-α抗体に関するギモンを解決!-2)抗TNF-α抗体を「中止する」ときを見極めるポイント. 薬局. 2016. 67. 6
  • 小林拓, 豊永貴彦, 齊藤詠子, 中野雅, 日比紀文. 難治性潰瘍性大腸炎の適切な治療戦略を考える!チオプリン系免疫調節薬による難治性潰瘍性大腸炎の治療戦略. IBD Research. 2016. 10. 2
Lectures and oral presentations  (21):
  • Zinc deficiency is a risk factor for mucosal inflammation in patients with ulcerative colitis
    (第101回日本消化器内視鏡学会総会 2021)
  • 高齢者潰瘍性大腸炎治療の特徴と留意点
    (第17回日本消化管学会総会 2021)
  • Decreased colonic activin receptor-like kinase 1 disrupts epithelial barrier integrity and is associated with a poor clinical outcome in Crohn’s disease.
    (Crohn’s & Colitis Congress 2020)
  • Patient-reported Outcome is More Reliable than Fecal Calprotectin in Detecting Early Response to Remission Induction Treatment in Ulcerative Colitis
    (The 5th Annual Meeting of the Asian Organization for Crohn’s and Colitis 2017)
  • Usefulness of fecal S100A12 in detecting early response to remission induction treatment in ulcerative colitis.
    (Crohn’s & Colitis Fundation’s Clinical & Research Conference)
Awards (7):
  • 2017 - Japanese Society of Gastroenterology Support for Young Gastroenterologists Studying in the United States
  • 2015/06 - The 3rd Annual Meeting of Asian Organization for Crohn’s & Colitis Distinct Abstract Award
  • 2015/06 - Japanese Society of Inflammatory Bowel Diseases Travel Award (for The 3rd Annual Meeting of Asian Organization for Crohn’s & Colitis)
  • 2014/12 - Japanese Society of Inflammatory Bowel Diseases ravel Award (for Crohn’s & Colitis Fundation’s Clinical & Research Conference 2014)
  • 2013/10 - Japanese Society of Gastroenterology Support for Young Researchers to Join International Academic Meeting
Show all
Association Membership(s) (6):
Asian Organization for Crohn's and Colitis ,  Japanese Society of Inflammatory Bowel Diseases ,  American Gastroenterological Association ,  Japanese Society of Gastroenterological Endoscopy ,  Japanese Society of Gastroenterology ,  Japanese Society of Internal Medicine
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