TOYONAGA TAKAHIKO

トヨナガタカヒコ | TOYONAGA TAKAHIKO

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Gastroenterology

Research keywords (4)： inflammatory bowel disease , microRNA , intestinal epithelial cell , gut microbiota

Research theme for competitive and other funds (7)：

2023 - 2024 Unravelling the impact of environmental exposures on intestinal epithelial cell homeostasis through disruption of circulating microRNAs
2021 - 2024 Increased miR-155-5p disrupts colonic JAK-STAT regulation and impairs tofacitinib efficacy in ulcerative colitis
2021 - 2023 Developing a novel treatment for Crohn's colitis by inducing differentiation in intestinal epithelial cells
2019 - 2020 Increased epithelial cell miR-31 expression disrupts the intestinal barrier in Crohn’s Disease
2016 - 2018 Unveiling the impact of disrupted intracellular iron regulation in intestinal macrophages on the pathophysiology of inflammatory bowel disease

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Papers (37)：

Akira Komatsu, Takahiko Toyonaga, Natsuki Sumiyoshi, Miho Tanaka, Naoki Shibuya, Masayuki Saruta. Endoscopic healing is associated with a reduced risk of biologic treatment failure in patients with ulcerative colitis. Scientific reports. 2024. 14. 1. 303-303
Satoshi Yamada, Yusuke Honzawa, Shuji Yamamoto, Minoru Matsuura, Hiroki Kitamoto, Makoto Okabe, Nobuyuki Kakiuchi, Takahiko Toyonaga, Taku Kobayashi, Toshifumi Hibi, et al. Single Nucleotide Polymorphisms of the MEFV Gene E148Q Are Highly Associated With Disease Phenotype in Crohn's Disease. Inflammatory bowel diseases. 2023
Kenji Watanabe, Masanori Nojima, Hiroshi Nakase, Toshiyuki Sato, Minoru Matsuura, Nobuo Aoyama, Taku Kobayashi, Hirotake Sakuraba, Masakazu Nishishita, Kaoru Yokoyama, et al. Trajectory analyses to identify persistently low responders to COVID-19 vaccination in patients with inflammatory bowel disease: a prospective multicentre controlled study, J-COMBAT. Journal of gastroenterology. 2023
粟田潤, 酒寄千晶, 澁谷尚希, 宮崎亮佑, 上田薫, 豊永貴彦, 櫻井俊之, 光永眞人, 山崎琢士, 猿田雅之. 基礎疾患のない高齢者に生じたサイトメガロウイルス巨大十二指腸潰瘍の一例. Progress of Digestive Endoscopy. 2023. 103. Suppl. s119-s119
Erin C. Steinbach, Johanna M. Smeekens, Satyaki Roy, Takahiko Toyonaga, Caleb Cornaby, Layna B. Perini, Ana E. Berglind, Michael D. Kulis, Edwin H. Kim, Martin T. Ferris, et al. Intestinal epithelial cell barrier dysfunction and elevated Angiopoietin-like 4 identified in orally susceptible peanut allergy model. Clinical & Experimental Allergy. 2023

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MISC (16)：

豊永貴彦, 猿田雅之. 炎症性腸疾患と微量ミネラル欠乏. 日本医師会雑誌. 2021. 150. 3. 465-468
豊永貴彦, 櫻井俊之, 猿田雅之. The role of epithelioid granuloma in inflammatory bowel disease. 月刊呼吸器内科. 2020. 38. 6
豊永貴彦, 小林拓, 斉藤詠子, 岡林慎二, 日比紀文. IBD治療のピットフォール第13回 IBD患者のアドヒアランス不良例. IBD Research. 2017. 11. 1
Takahiko Toyonaga, Minoru Matsuura, Hiroshi Nakase, Kiyoshi Mori, Taku Kobayashi, Toshifumi Hibi. Lipocalin2 affecting bacterial clearance in activated macrophages contributes to the onset of intestinal inflammation. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2016. 31. 148-148
小林拓, 豊永貴彦, 齊藤詠子, 中野雅, 日比紀文. 炎症性腸疾患徹底解説!抗TNF-α抗体に関するギモンを解決!-2)抗TNF-α抗体を「中止する」ときを見極めるポイント. 薬局. 2016. 67. 6

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Books (1)：

診療所で見極めるIBD診療 : 慈恵医大猿田式
日本医事新報社 2023 ISBN:9784784963508

Lectures and oral presentations (30)：

炎症性腸疾患における予測メタゲノム解析を用いた新規治療薬の探索
(第31回日本消化器関連学会週間(JDDW2023) 2023)
高度な免疫抑制治療により症状的寛解を得た潰瘍性大腸炎患者における5-アミノサリチル酸製剤減量および中止の安全性検討
(第31回日本消化器関連学会週間(JDDW2023) 2023)
Clinical features of eosinophilic enterocolitis mimicking inflammatory bowel disease
(第31回日本消化器関連学会週間(JDDW2023) 2023)
クローン病における腸内細菌機能変化を介したケノデオキシコール酸代謝異常の解明
(第31回日本消化器関連学会週間(JDDW2023) 2023)
潰瘍性大腸炎の病変範囲把握における腸管超音波検査の有用性検討
(日本超音波医学会第96回学術集会 2023)

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Awards (7)：

2017 - Japanese Society of Gastroenterology Support for Young Gastroenterologists Studying in the United States
2015/06 - The 3rd Annual Meeting of Asian Organization for Crohn’s & Colitis Distinct Abstract Award
2015/06 - Japanese Society of Inflammatory Bowel Diseases Travel Award (for The 3rd Annual Meeting of Asian Organization for Crohn’s & Colitis)
2014/12 - Japanese Society of Inflammatory Bowel Diseases ravel Award (for Crohn’s & Colitis Fundation’s Clinical & Research Conference 2014)
2013/10 - Japanese Society of Gastroenterology Support for Young Researchers to Join International Academic Meeting

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Association Membership(s) (6)：

Asian Organization for Crohn's and Colitis , Japanese Society of Inflammatory Bowel Diseases , American Gastroenterological Association , Japanese Society of Gastroenterological Endoscopy , Japanese Society of Gastroenterology , Japanese Society of Internal Medicine

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