Rchr
J-GLOBAL ID：202101006876711445   Update date: Aug. 22, 2022

Shiraishi Koichi

シライシ コウイチ | Shiraishi Koichi
Affiliation and department：
Jikei University Division of Medical Engineering

About Jikei University Division of Medical Engineering


Research field  (2)： Polymer chemistry ,  Biomaterials
Research keywords  (6)： Poly(ethylene glycol) ,  anti-PEG antibodies ,  Antigenecity and immunogenicity ,  biomaterial science ,  Polymer micelles ,  MRI contrast agent
Research theme for competitive and other funds  (7)：
  • 2020 - 2025 Biophysical Chemistry for Material Symbiosis
  • 2020 - 2025 Elucidation of origin of weak interactions of synthetic polymers with its specific proteins
  • 2022 - 2024 非免疫原性分子の免疫的な記憶の解明
  • 2020 - 2023 Elucidation of cerebral circulation by the use of polymeric MRI contrast agents
  • 2020 - 2022 Elucidation of a simple role in the antibody diversity
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Papers (17)：
  • Masayuki Yokoyama, Kouichi Shiraishi. Stability evaluation of Gd chelates for macromolecular MRI contrast agents. Magma (New York, N.Y.). 2020. 33. 4. 527-536
  • Kouichi Shiraishi, Masayuki Yokoyama. Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review. Science and technology of advanced materials. 2019. 20. 1. 324-336
  • Hiroyuki Akai, Kouichi Shiraishi, Masayuki Yokoyama, Koichiro Yasaka, Masanori Nojima, Yusuke Inoue, Osamu Abe, Kuni Ohtomo, Shigeru Kiryu. PEG-poly(L-lysine)-based polymeric micelle MRI contrast agent: Feasibility study of a Gd-micelle contrast agent for MR lymphography. Journal of magnetic resonance imaging : JMRI. 2018. 47. 1. 238-245
  • Kouichi Shiraishi, Shin-Ichi Yusa, Masanori Ito, Keita Nakai, Masayuki Yokoyama. Photo Irradiation-Induced Core Crosslinked Poly(ethylene glycol)-block-poly(aspartic acid) Micelles: Optimization of Block Copolymer Synthesis and Characterization of Core Crosslinked Micelles. Polymers. 2017. 9. 12
  • Kouichi Shiraishi, Zuojun Wang, Daisuke Kokuryo, Ichio Aoki, Masayuki Yokoyama. A polymeric micelle magnetic resonance imaging (MRI) contrast agent reveals blood-brain barrier (BBB) permeability for macromolecules in cerebral ischemia-reperfusion injury. Journal of controlled release : official journal of the Controlled Release Society. 2017. 253. 165-171
ｍore...
MISC (2)：
  • 白石 貢一. 【物質共生の観点からDDSを考える】生体親和性高分子PEGの弱い相互作用と、それを起点とする生体応答の解明. Drug Delivery System. 2022. 37. 2. 122-130
  • 白石 貢一. 分子プローブ開発の視点から見出されるポリエチレングリコール(PEG)における免疫応答. JSMI Report. 2021. 14. 2. 10-16
Association Membership(s) (6)：
American Chamical Society ,  The Chemical Soceity of Japan ,  Japanese Soceity for Molecular Imaging ,  The Japaneses Soceity for Biomaterials ,  The Society of Polymer Science Japan ,  The Japan Society of Drug Delivery Systems
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