Kimura Haruka

キムラハルカ | Kimura Haruka

Research field (1)： Cardiology

Research keywords (5)： Adipose Tissue , Heart Failure , insulin resistance , Thermogenesis , natriuretic peptides

Research theme for competitive and other funds (2)：

2021 - 2024 Natriuretic Peptides Induce Thermogenesis and Improve Insulin Resistance
2015 - 2018 A relationship among the low-reactivity of natriuretic peptide, insulin resistance and ischemic heart disease

Papers (37)：

Yoshiro Tanaka, Tomohisa Nagoshi, Hirotake Takahashi, Yuhei Oi, Rei Yasutake, Akira Yoshii, Haruka Kimura, Yusuke Kashiwagi, Toshikazu D Tanaka, Masayuki Shimoda, et al. URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease. iScience. 2023. 26. 9. 107730-107730
木村悠, 吉村道博. 【臨床冠動脈疾患学-冠動脈疾患の最新治療戦略-】冠動脈疾患の治療薬物療法 Ca拮抗薬の最前線. 日本臨床. 2023. 81. 増刊8 臨床冠動脈疾患学. 300-305
Yusuke Kashiwagi, Tomohisa Nagoshi, Haruka Kimura, Yoshiro Tanaka, Yuhei Oi, Yasunori Inoue, Kazuo Ogawa, Makoto Kawai, Michihiro Yoshimura. Effects of angiotensin receptor-neprilysin inhibitor on insulin resistance in patients with heart failure. ESC heart failure. 2023. 10. 3. 1860-1870
Yuhei Oi, Tomohisa Nagoshi, Haruka Kimura, Yoshiro Tanaka, Akira Yoshii, Rei Yasutake, Hirotake Takahashi, Yusuke Kashiwagi, Toshikazu D Tanaka, Toshiaki Tachibana, et al. Exogenous ANP Treatment Ameliorates Myocardial Insulin Resistance and Protects against Ischemia-Reperfusion Injury in Diet-Induced Obesity. International journal of molecular sciences. 2022. 23. 15
Hirotake Takahashi, Tomohisa Nagoshi, Haruka Kimura, Yoshiro Tanaka, Rei Yasutake, Yuhei Oi, Akira Yoshii, Toshikazu D Tanaka, Yusuke Kashiwagi, Michihiro Yoshimura. Substantial impact of 3-iodothyronamine (T1AM) on the regulations of fluorescent thermoprobe-measured cellular temperature and natriuretic peptide expression in cardiomyocytes. Scientific reports. 2022. 12. 1. 12740-12740

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MISC (9)：

木村悠, 名越智古, 吉村道博. ANP投与はNAFLD改善と脂肪組織褐色化を介して肥満マウスのインスリン抵抗性改善と寒冷曝露に対する体温保持効果を示す. 日本内分泌学会雑誌. 2022. 97. 5. 1475-1475
木村悠, 小川崇之. 【虚血性心疾患診療のいま】虚血を治す・予防する(薬物・非薬物治療の進歩) 慢性冠症候群の病態と抗狭心症薬の使い分け. 日本内科学会雑誌. 2021. 110. 2. 226-231
Haruka Kimura, Tomohisa Nagoshi, Akira Yoshii, Yoshiro Tanaka, Oi Yuhei, Michihiro Yoshimura. Adipose Tissue Browning Induced by Natriuretic Peptide Exerts Thermogenic Actions and Improves Insulin Resistance in an in vivo Model of Diet-Induced Obese Mice. CIRCULATION RESEARCH. 2019. 125
Akira Yoshii, Nagoshi Tomohisa, Yusuke Kashiwagi, Haruka Kimura, Yoshiro Tanaka, Oi Yuhei, Keiichi Ito, Takuya Yoshino, Toshikazu D. Tanaka, Yoshimura MIchihiro. SGLT1 is Essential for Cardioprotection During Ischemia-Reperfusion Injury via Enhanced Glucose Utilization in Diet-induced Obese Mice. CIRCULATION RESEARCH. 2019. 125
Haruka Kimura, Tomohisa Nagoshi, Akira Yoshii, Yoshiro Tanaka, Keiichi Ito, Toshikazu D. Tanaka, Michihiro Yoshimura. Natriuretic Peptide Induces Adipose Tissue Browning and Exerts Thermogenic Actions in an in vivo Model of Diet Induced Obesity. CIRCULATION. 2018. 138

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Lectures and oral presentations (10)：

Non-Alcoholic Fatty Liver and Adipose Tissue Inflammation Are Improved by Exogenous A-type Natriuretic Peptide Treatment in Diet-Induced Obese Mice (Oral Presentation).
(第39回国際心臓研究学会(ISHR)日本部会) 2022)
ANP投与はNAFLD改善と脂肪組織褐色化を介して肥満マウスのインスリン抵抗性改善と寒冷暴露に対する体温保持効果を示す(YIA Session).
(第25回日本心血管内分泌代謝学会(CVEM)学術総会 2021)
肥満マウスにおけるANP投与はNAFLD改善・脂肪組織browningを介してインスリン抵抗性改善と保温効果を示す(Basic・Transrational Research Award)
(第262回日本循環器学会関東甲信越地方会 2021)
The Heart Symposium ナトリウム利尿ペプチドの脂肪組織に対する作用と体温保持機能への関与.
(第85回日本温泉気候物理医学会学術集会(シンポジウム講演) 2021)
Adipose Tissue Browning Induced by Natriuretic Peptide Exerts Thermogenic Actions and Improves Insulin Resistance in an in vivo Model of Diet-Induced Obese Mice (Poster Session)
(Basic Cardiovascular Sciences 2019 Scientific Sessions. 2019)

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Education (2)：

2015 - 2019 Jikei University Division of Cardiology
2002 - 2008 The Jikei University School of Medicine Faculty of Medicine School of Medicine

Work history (7)：

2024/02 - 現在 The Jikei University School of Medicine Internal Medicine, Division of Cardiology Associate Professor
2019/04 - 2024/01 The Jikei University School of Medicine Internal Medicine, Division of Cardiology Research Associate
2015/04 - 2019/04 東京慈恵会医科大学大学院医学研究科循環器内科学専攻博士課程
2013/04 - 2015/03 東京慈恵会医科大学附属柏病院循環器内科助教
2012/04 - 2013/03 埼玉県立循環器呼吸器病センター循環器内科

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Awards (6)：

2021/12 - YIA Finalist
2021/12 - The Japanese Circulation Society Basic・Translational Research Award Finalist
2019/02 - YIA Finalist
2018/12 - Advans Encourage Award
2018/01 - The Japanese Circulation Society The 1st JCS Council Forum on Basic CardioVasclula Research Certificate Poster Award Thermogenic Effects of Natriuretic Peptide on Brown Adipocytes in a Low Temperature-Sensitive Manner

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Association Membership(s) (7)：

International Society for Heart Research (Japanese Section) , 日本心脈管作動物質学会 , 日本心血管内分泌代謝学会 , Japanese Association of Cardiovascular Intervention and Therapeutics:CVIT , Japanese Society of Echocardiography , 日本循環器学会 , 日本内科学会

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