Research field (3)：
Orthopedics
, Cell biology
, Molecular biology
Research keywords (6)：
MMPRT
, Meniscus injury, meniscus tear
, Meniscus repair
, ACL injury
, Osteoarthritis of the knee
, 軟骨代謝、半月板細胞生物学、転写制御、クロマチン
Research theme for competitive and other funds (24)：
2021 - 2024 内側半月板後根断裂の治癒促進と膝関節軟骨変性の抑制
2019 - 2021 Cartilage protection by mechanical stress - changes of Exosome contents-
2018 - 2021 Development of a New Evaluation Method for Exercise Training Using Mitochondrial Activation of Peripheral Blood Mononuclear Cells
2016 - 2019 Analysis of cartilage protection by mechanical stress -miRNA and extracellular vesicles functions in osteoarthritis-
2016 - 2019 Meniscus cell differentiation and meniscal regeneration
2015 - 2018 Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational research
2013 - 2016 p53-expressing oncolytic adenovirus enhances the anti-tumor effect of chemotherapy and radiotherapy
2015 - 2016 前十字靭帯-外側半月板複合体の機能解析
2014 - 2015 膝関節鏡を用いた前十字靭帯-外側半月板複合体の機能解析
2012 - 2015 Promotion of meniscal healing and regeneration
2012 - 2013 SOX9遺伝子導入による半月板修復と再生医療への応用
2012 - 2013 肩腱板組織における最終糖化産物の沈着と組織変性に関する研究
2011 - 2013 Functional analysis of CCN2 as a metabolic supporter and potential clinical applications in chondrocyte regeneration
2011 - 2012 遺伝子導入による靭帯-骨軟骨接合部(enthesis)の再生
2010 - 2011 靭帯損傷に対する成長因子徐放化3次元ゲルの応用
2010 - 2011 3次元培養ペプチドゲルを用いた靭帯損傷に対する内視鏡的治療法の開発
2009 - 2010 靭帯 -骨軟骨接合部におけるScleraxisとSox9の機能解析
2009 - 2010 3次元軟骨培養細胞の力学的負荷による軟骨細胞の遺伝子発現変化
2008 - 2010 Gene therapy in the treatment of ligament injury
2008 - 2010 Elucidation of the mechanism of aggrecan degradation and epigenetic regulation of aggrecanase expression in osteoarthritic cartilage
2008 - 2009 膝関節鏡による遺伝子導入法を応用した靭帯組織再生技術の確立
2007 - 2009 上皮間葉移行における腫瘍浸潤能獲得の解明とヒストン修飾と腫瘍悪性化の関連性
2006 - 2008 Sox9周辺遺伝子導入による滑膜由来軟骨細胞分化の誘導と軟骨移植
超音波刺激を用いた半月板・軟骨の変性抑制効果 - 膝関節鏡による検討 -
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Papers (381)：
Koki Kawada, Yuki Okazaki, Masanori Tamura, Yusuke Yokoyama, Toshifumi Ozaki, Takayuki Furumatsu. Accurate tibial tunnel position in transtibial pullout repair for medial meniscus posterior root tears delays the progression of medial joint space narrowing. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 2024
Koki Kawada, Takayuki Furumatsu, Yusuke Yokoyama, Naohiro Higashihara, Masanori Tamura, Toshifumi Ozaki. Meniscal healing status after medial meniscus posterior root repair negatively correlates with a midterm increase in medial meniscus extrusion. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 2024
Koki Kawada, Takayuki Furumatsu, Yusuke Yokoyama, Naohiro Higashihara, Masanori Tamura, Toshifumi Ozaki. Longitudinal changes in medial meniscus extrusion and clinical outcomes following pullout repair for medial meniscus posterior root tears: a 3-year evaluation. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie. 2024
桑原実穂, 廣瀬一樹, 廣瀬一樹, 奥田龍一郎, HABUMUGISHA Janvier, 近藤星, FU Shanqi, 大野充昭, 古松毅之, 中田英二, et al. CCN3, a senescence marker of cartilage, correlate with osteoarthritis irrespective of age and weight bearing. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
東原直裕, 東原直裕, 東原直裕, 青山絵理子, 古松毅之, 久保田聡, 尾崎敏文, 滝川正春. The effects of binding of CCN2 to GDF5 and its receptors on chondrocytes. 日本軟骨代謝学会プログラム・抄録集. 2023. 35th
2009/06 - 日本膝関節学会 日本膝関節学会賞 The best paper of the year, basica(廣畑賞) 前十字靭帯?骨軟骨接合部におけるScleraxisとSox9の役割?遺伝子導入による靭帯断裂部修復を目指して?
2009/02 - Orthopaedic Research Society 55th Orthopaedic Research Society New investigator recognition award Smad3 activates the Sox9-dependent transcription on chromatin.
