Arioka Masaki

アリオカマサキ | Arioka Masaki

Affiliation and department：
Job title： Lecturer/Associate professor

Research field (3)： Tumor biology , Surgical dentistry , Pharmacology

Research keywords (7)： Fibrosis , Wnt signaling pathway , Implant osseointegration , Osteoporosis , Bone biology, bone healing and bone regeneration , Tumor microenvironment and cancer stem cells , Developing anti-cancer drugs

Research theme for competitive and other funds (10)：

2024 - 2027 Development of a novel therapeutic agent to prevent the onset of heart failure associated with reperfusion therapy for acute myocardial infarction
2024 - 2027 Development of IPF Therapeutics Targeting Lipofibroblast Using GSK-3 Activators as Lead Compounds
2024 - 2027 Investigation of the potential of Differentiation-inducing factor-1 as a prophylactic agent for cancer metastasis by targeting circulating tumor cells
2023 - 2024 Fundamental research for the development of differentiation-inducing factor-1 as a preventive agent for cancer metastasis
2020 - 2023 Elucidation of the mechanism of inhibition of cancer metastasis by differentiation-inducing factor-1

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Papers (41)：

Takehiro Kishigami, Shin Ishikane, Masaki Arioka, Kazunobu Igawa, Yosuke Nishimura, Fumi Takahashi-Yanaga. 2,5-Dimethyl-celecoxib induces early termination of inflammatory responses by transient macrophage accumulation and inhibits the progression of cardiac remodeling in a mouse model of cryoinjury-induced myocardial infarction. Journal of Pharmacological Sciences. 2024. 154. 2. 97-107
Masaki Arioka, Fumi Seto-Tetsuo, Takeru Inoue, Koichi Miura, Shin Ishikane, Kazunobu Igawa, Katsuhiko Tomooka, Fumi Takahashi-Yanaga, Toshiyuki Sasaguri. Differentiation-inducing factor-1 reduces lipopolysaccharide-induced vascular cell adhesion molecule-1 by suppressing mTORC1-S6K signaling in vascular endothelial cells. Life sciences. 2023. 335. 122278-122278
Ishikane S, Arioka M, Takahashi-Yanaga F. Promising small molecule anti-fibrotic agents: Newly developed or repositioned drugs targeting myofibroblast transdifferentiation. Biochemical pharmacology. 2023
Takeru Inoue, Koichi Miura, Ruzhe Han, Fumi Seto-Tetsuo, Masaki Arioka, Kazunobu Igawa, Katsuhiko Tomooka, Toshiyuki Sasaguri. Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission. Journal of Pharmacological Sciences. 2023. 152. 1. 39-49
Fumi Seto-Tetsuo, Masaki Arioka, Koichi Miura, Takeru Inoue, Kazunobu Igawa, Katsuhiko Tomooka, Toshiyuki Sasaguri. DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells. International Immunopharmacology. 2023. 117. 109913-109913

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Books (1)：

ベッドサイドの薬理学
丸善出版 2018

Lectures and oral presentations (66)：

Celecoxib inhibited the skin fibrosis via suppression of preadipocyte- myofibroblasts transition by downregulating YAP/TAZ signaling pathway
(2023)
The role of myofibroblasts in cardiac fibrosis: Application to the treatment of heart failure
(2023)
2,5-ジメチルセレコキシブは一過性のマクロファージ集積による炎症反応の早期収束により冷凍焼灼心筋梗塞モデルマウスにおける心臓リモデリングの進行を抑制する
(第76回日本薬理学会西南部会 2023)
2,5-Dimethylcelecoxib prevents cardiac remodeling associated with myocardial ischemia/reperfusion injury in mice
(2022)
Differentiation-inducing factor-1 inhibits cancer cell adhesion to vascular endothelial cells via curtailing VCAM-1 protein synthesis
(The 96th Annual Meeting of the Japanese Pharmacological Society 2022)

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Education (2)：

2010 - 2014 Kyushu University Graduate School of Dental Science
2002 - 2008 Kyushu University School of Dentistry

Professional career (1)：

Ph.D. (Kyushu University)

Work history (4)：

2022/04 - 現在 University of Occupational and Environmental Health, Japan Department of Pharmacology, School of Medicine Lecturer/Associate Professor
2019/10 - 2022/03 Kyushu University Department of Clinical Pharmacology, Faculty of Medical Sciences Assistant professor
2017/07 - 2019/09 Stanford University Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine Visiting scholar
2014/04 - 2017/07 Kyushu University Department of Clinical Pharmacology, Faculty of Medical Sciences Assistant professor

Committee career (1)：

2022/04 - 現在 The Japanese Pharmacological Society Councilor

Awards (9)：

2019/06 - American Association Dental Research AADR Hatton Award Finalist
2015/11 - 48th Annual Meeting of the American Society of Nephrology Top Oral Abstracts for ASN
2014/06 - 日本学生支援機構日本学生支援機構大学院第一種奨学金全額免除(特に優れた業績による返還免除)
2014/03 - 九州大学九州大学学生表彰(学術研究活動)
2014/03 - 九州大学大学院歯学府藤野博賞

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Association Membership(s) (7)：

Japanese Society of Clinical Pharmacology and Therapeutics , Japanese Association of Oral Biology , International Association of Dental Research , Japanese Cancer Association , Japanese Pharmacological Society , Japanese Society of Oral and Maxillofacial Surgery , Japanese Society of Oral Implantology

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